Results 341 to 350 of about 193,772 (411)

4′-Modified Nucleosides for Antiviral Drug Discovery: Achievements and Perspectives

Accounts of Chemical Research, 2022
ConspectusModified nucleosides show therapeutic promise for antiviral therapies. However, issues including the emergence of drug resistance, toxicity, and coinfections have posed new challenges for nucleoside-based antiviral drug discovery, particularly ...
Junbiao Chang
exaly   +2 more sources

Selenium‐Mediated Dehalogenation of Halogenated Nucleosides and its Relevance to the DNA Repair Pathway

Angewandte Chemie - International Edition, 2015
Halogenated nucleosides can be incorporated into the newly synthesized DNA of replicating cells and therefore are commonly used in the detection of proliferating cells in living tissues.
Santanu Mondal, Debasish Manna, Govindasamy Mugesh   +2 more
exaly   +2 more sources

Synthesis of 2,6‐Dihalogenated Purine Nucleosides by Thermostable Nucleoside Phosphorylases

Advanced Synthesis and Catalysis, 2015
The enzymatic transglycosylation of 2,6-di- chloropurine (26DCP) and 6-chloro-2-fluoropurine (6C2FP) with uridine, thymidine and 1-(b-d-arabino- furanosyl)-uracil as the pentofuranose donors and re- combinant thermostable nucleoside phosphorylases from G.
Xinrui Zhou, Lin-yu Jiao, Martin Oestreich   +2 more
exaly   +2 more sources

Advances in the enantioselective synthesis of carbocyclic nucleosides

Chemical Society Reviews, 2013
Carbocyclic nucleosides are nucleoside analogues in which the furanosidic moiety has been replaced by a carbocycle. Several members of this family have been isolated from natural sources and include a 5-membered ring carbocycle. The aim of this review is
Omar Boutureira, M Isabel Matheu, Yolanda Díaz   +2 more
exaly   +2 more sources

Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases

Pharmacology & Therapeutics, 2000
Nucleoside monophosphate kinases catalyze the reversible phosphotransferase reaction between nucleoside triphosphates and monophosphates, i.e., monophosphates are converted to their corresponding diphosphate form. These enzymes play an important role in the synthesis of nucleotides that are required for a variety of cellular metabolic processes, as ...
Anna Karlsson, Magnus Johansson, An R. Van Rompay   +2 more
openaire   +3 more sources

C-Nucleosides To Be Revisited.

Journal of Medicinal Chemistry, 2016
Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a phosphoramidate derivative of 1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine C-nucleoside, have been recently described as effective against filovirus infections (Marburg ...
E. Clercq
semanticscholar   +2 more sources

Advancement in the development of heterocyclic nucleosides for the treatment of cancer - A review

Nucleosides, Nucleotides & Nucleic Acids, 2019
Cancer diseases are widely recognised as an important medical problem and killing millions of people in a year. Chemotherapeutic drugs are successful against cancer in many cases and different compounds, including the analogues of natural substances, may
A. Mirza
semanticscholar   +1 more source

Nucleosides

ChemInform, 1990
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

Chromatography of nucleosides

Journal of Chromatography A, 1980
Abstract The chromatographic parameters affectingthe reversed-phase high-performance liquid chromatographic (HPLC) separation of major and modified nucleosides with a μBondapak C 18 column have been studied. This investigation has resulted in the HPLC separation of eighteen nucleosides in a single analysis. The parameters studied include: the mobile
Kenneth C. Kuo, Charles W. Gehrke, Robert W. Zumwalt   +2 more
openaire   +3 more sources

Bromination of nucleosides

Experientia, 1970
Mit N-Bromsuccinimid konnen Nukleoside in Dimethylformamid mit guter Ausbeute zu den in 5-Stellung bromierten Derivaten umgewandelt werden.
K. L. Nagpal, P. C. Srivastava
openaire   +2 more sources