Results 361 to 370 of about 193,772 (411)
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ChemInform Abstract: Glycosylation of Nucleosides.
ChemInform, 2016AbstractOptimized conditions for the O‐glycosylation of nucleoside hydroxyls are developed.
Spencer Knapp, Yonglian Zhang
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The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors
Clinics in Liver Disease, 2011This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical ...
Eric Lawitz, Fernando E. Membreno
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Analytical Chemistry, 2013
Ribosylated metabolites, especially modified nucleosides, have been extensively evaluated as cancer-related biomarkers. Boronate adsorbents are considered to be promising materials for extracting them from complex matrices.
Hua Li +5 more
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Ribosylated metabolites, especially modified nucleosides, have been extensively evaluated as cancer-related biomarkers. Boronate adsorbents are considered to be promising materials for extracting them from complex matrices.
Hua Li +5 more
semanticscholar +1 more source
, 2014
Nucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C2- or C8-modified purines have been particularly studied.
G. Hervé +4 more
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Nucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C2- or C8-modified purines have been particularly studied.
G. Hervé +4 more
semanticscholar +1 more source
Binding of DNA nucleobases and nucleosides with graphene.
ChemPhysChem, 2009Interaction of two different samples of graphene with DNA nucleobases and nucleosides is investigated by isothermal titration calorimetry. The relative interaction energies of the nucleobases decrease in the order guanine (G)>adenine (A)>cytosine (C ...
Neenu Varghese +6 more
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Thieno analogues of RNA nucleosides: a detailed theoretical study.
Journal of Physical Chemistry B, 2012We use first-principles density functional theory calculations to investigate the structural, energetic, bonding aspects, and optical properties of recently synthesized thieno-analogues of RNA nucleosides.
P. K. Samanta, Arun K. Manna, S. Pati
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C-nucleosides: synthetic strategies and biological applications.
Chemical Reviews, 2009While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed hydrolysis of the nucleosidic bond, their C-analogues are much more stable.
J. Štambaský +2 more
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Metabolic network of nucleosides in the brain.
Current Topics in Medicinal Chemistry, 2011Brain relies on circulating nucleosides, mainly synthesised de novo in the liver, for the synthesis of nucleotides, RNA, nuclear and mitochondrial DNA, coenzymes, and pyrimidine sugar- and lipid-conjugates. Essentially, the paths of nucleoside salvage in
P. L. Ipata +3 more
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One-flow, multistep synthesis of nucleosides by Brønsted acid-catalyzed glycosylation.
Angewandte Chemie, 2011Nucleosides and their structural variants are a well-established and important class of antiviral and anticancer agents. More recently, they have become the chemical centerpiece of the development of genetic therapies, biological probes, and modern DNA ...
A. Sniady, Matthew W. Bedore, T. Jamison
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Journal of the Chemical Society C: Organic, 1971
A new route for the preparation of 4-amino-1-(β-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine (5)(6-azatubercidin) is described. The anomeric configuration of the product has been established unequivocally for the first time by cyclonucleoside formation, and agrees with previously reported anomeric assignments.
Leroy B. Townsend, Ganapthi R. Revankar
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A new route for the preparation of 4-amino-1-(β-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine (5)(6-azatubercidin) is described. The anomeric configuration of the product has been established unequivocally for the first time by cyclonucleoside formation, and agrees with previously reported anomeric assignments.
Leroy B. Townsend, Ganapthi R. Revankar
openaire +3 more sources