Results 31 to 40 of about 193,772 (411)
Nature Communications, 2018 The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet–dry ...
S. Becker +6 more
semanticscholar +1 more source
Metabolites, 2021 Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential ...
Kuei-Hung Lai +9 more
doaj +1 more source
Combining simulations and solution experiments as a paradigm for RNA force field refinement [PDF]
J. Chem. Theory Comput., 2016, 12 (12), pp 6192-6200, 2016 Recent computational efforts have shown that the current potential energy models used in molecular dynamics are not accurate enough to describe the conformational ensemble of RNA oligomers and suggest that molecular dynamics should be complemented with experimental data.
arxiv +1 more source
Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]
, 2012 Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz +60 more
core +2 more sources
UV resistance of nucleosides -- an experimental approach [PDF]
, 2020 The emergence of life on Earth is a highly discussed but still unsolved question. Current research underlines the importance of environments within close proximity to the Earth's surface as they can solve long-standing problems such as polymerization of nucleotides and phosphorylation of nucleosides.
arxiv +1 more source
Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. [PDF]
, 2017 A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization.
Fin, Andrea +2 more
core +1 more source
Identification and quantification of modified nucleosides in Saccharomyces cerevisiae mRNAs
bioRxiv, 2018 Post-transcriptional nucleoside modifications have long been recognized as key modulators of non-coding RNA structure and function. There is an emerging appreciation that the chemical modification of protein-coding messenger RNAs (mRNAs) also plays ...
Mehmet Tardu, Q. Lin, Kristin S. Koutmou
semanticscholar +1 more source
Frontiers in Veterinary Science, 2020 An in ovo study on the effect of the administration of a combination of nucleosides (25, 50, and 100 mg/egg) on hatchability, growth performance, energy metabolizability, and intestinal morphology in broilers was carried out.
Marappan Gopi +9 more
doaj +1 more source
Mathematical model of immune response to hepatitis B [PDF]
J. Theor. Biol. 447, 98-110 (2018), 2018 A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a ...
arxiv +1 more source
Separation of oxidatively damaged DNA Nucleobases and Nucleosides on Packed and Monolith C18 Columns by HPLC-UV-EC [PDF]
, 2008 This study involves the incorporation of a commercially available Phenomenex Onyx C18 monolith column into the separation and detection of oxidative DNA damage.
Kelly, Michele C. +2 more
core +1 more source