Mutations to the histone H3 αN region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions [PDF]
, 2009 Joanna Somers, Tom Owen‐Hughes
openalex +1 more source
Structure and regulation of the human INO80–nucleosome complex
Nature, 2018 Rafael Ayala +7 more
semanticscholar +1 more source
License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication
BioEssays, Volume 48, Issue 1, January 2026.Origin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Victoria Frisbie, Franziska Bleichert
wiley +1 more source
End-repair causes methylation underestimation in cell-free DNA sequencing libraries. [PDF]
J Liq BiopsyGroth TE +4 more
europepmc +1 more source
BioEssays, Volume 48, Issue 1, January 2026.We hypothesize that the TPL corepressor (and likely others) acts as a transcriptional linchpin, stabilizing a state similar yet distinct from the metazoan paused state by recruiting Mediator and other components needed to initiate and coordinate transcriptional bursts across multiple genes.
Alexander R. Leydon +1 more
wiley +1 more source
Nucleosome depletion alters the chromatin structure of Saccharomyces cerevisiae centromeres.
, 1990 M J Saunders +3 more
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Pioneer Factor FOXA1 Boosts CHO Cell Productivity
Biotechnology Journal, Volume 21, Issue 1, January 2026.Graphical Abstract and Lay Summary FOXA1 binds directly to the EF1α and CMV promoters that are widely used to drive transgene expression. It stimulates transcription by recruiting cofactors that manipulate the epigenetic environment, including TET1 that demethylates DNA, p300 that acetylates histones and SWI/SNF that remodels nucleosomes.
Sienna P. Butterfield +2 more
wiley +1 more source
HMGN1 and HMGN2 are recruited to acetylated and histone variant H2A.Z-containing nucleosomes to regulate chromatin state and transcription. [PDF]
J Biol ChemGohil R +5 more
europepmc +1 more source
Nucleosome periodicity in HeLa cell chromatin as probed by micrococcal nuclease.
, 1979 Tauseef R. Butt +2 more
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Dynamic Regulation of Nucleosome Positioning in the Human Genome
Cell, 2008 Dustin E. Schones +7 more
semanticscholar +1 more source