Results 271 to 280 of about 156,001 (374)

Customizing Native Chemical Ligation: A Case Study on Histone Variant H2A.B from Toolbox to Target

Chemistry–Methods, Volume 6, Issue 1, January 2026.
The core histone protein variant H2A.B, chosen as the target protein, is involved in many transcriptional processes regulated by its post‐translational modifications. Herein, the native chemical toolbox is harnessed to demonstrate the successful synthesis and semi‐synthesis of site‐specifically modified H2A.B variants via different strategies.
Tobias Gökler, Medine Soydan, Lydia Jane Barber, Garence Ferraton, Anne Claire Conibear   +4 more
wiley   +1 more source

Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome. [PDF]

Nat Commun
Matsumoto S, Takizawa Y, Ogasawara M, Hashimoto K, Negishi L, Xu W, Tachibana H, Yamamoto J, Iwai S, Sugasawa K, Kurumizaka H.   +10 more
europepmc   +1 more source

Chromatin Profiling Reveals Distinct Male and Female Trajectories for Developmental Learning Potential

Developmental Neurobiology, Volume 86, Issue 1, January 2026.
ABSTRACT Adult patterns of behavior can often be explained by developmental experiences. In some cases, developmental experience can have permanent influence on brain and behavior only during specific ages; these phases are called critical or sensitive periods. Epigenetic mechanisms can regulate both maturational and experiential processes in the brain
Grant W. Kunzelman, Alice Batistuzzo, Sarah E. London   +2 more
wiley   +1 more source

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions. [PDF]

Cell
Li H, Dalgleish JLT, Lister G, Maristany MJ, Huertas J, Dopico-Fernandez AM, Hamley JC, Denny N, Bloye G, Zhang W, Hentges L, Doll R, Wei Y, Maresca M, Dimitrova E, Pytowski L, Tunnacliffe EAJ, Kassouf M, Higgs D, de Wit E, Klose RJ, Schermelleh L, Collepardo-Guevara R, Milne TA, Davies JOJ.   +24 more
europepmc   +1 more source

Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing

Nature, 2018
Binbin Lai, Weiwu Gao, Kairong Cui, Wanli Xie, Qingsong Tang, Wenfei Jin, Gangqing Hu, B. Ni, K. Zhao   +8 more
semanticscholar   +1 more source

Extracellular vesicle‐based vaccines and immunotherapeutics for treatment of cancer

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review highlights the innovative value of extracellular vesicles (EVs) as cancer vaccines and immunotherapy carriers. EVs have natural advantages such as low immunogenicity, high biocompatibility, stability, and precise targeting, enabling efficient delivery of tumor antigens (e.g., HER2, AFP) and immune stimulants (e.g., TLR ligands, cytokines ...
Lejia Tan, Haonan Xing, Fang Fang, Yuanyu Huang, Mei Lu   +4 more
wiley   +1 more source

Molecular mechanism of co-transcriptional H3K36 methylation by SETD2. [PDF]

Nat Commun
Walshe JL, Ochmann M, Neef U, Dybkov O, Dienemann C, Oberthür C, Zheenbekova A, Urlaub H, Cramer P.   +8 more
europepmc   +1 more source

DNA‐Based Liquid Biopsy for Evaluating Surgical and Postsurgical Outcomes in Gynecologic Malignancies: A Systematic Review

Journal of Clinical Laboratory Analysis, Volume 40, Issue 1, January 2026.
Liquid biopsy using plasma and uterine aspirate samples provides a minimally invasive tool for detecting and monitoring gynecologic cancers. Circulating tumor DNA (ctDNA) and cell‐free DNA (cfDNA) enable prognosis, treatment response assessment, and improved diagnostic accuracy across various tumor types. ABSTRACT Introduction DNA‐based liquid biopsies,
Samaneh Yavari, Sepide Javankiani, Foroozan Yarahmadi, Rojin Sarallah, Behandokht Rezaei, Maryam Maroufi, Mona Khabbazkar Amlashi, Mahshid Imankhan, Mahnaz Marvi, Neda Aslani, Arezou Soltanattar, Zahra Mohammadi, Alireza Azani, Pegah Kavousinia   +13 more
wiley   +1 more source

Structural basis of nucleosome recognition by the conserved Dsup and HMGN nucleosome-binding motif. [PDF]

Genes Dev
Alegrio-Louro J, Cruz-Becerra G, Kassavetis GA, Kadonaga JT, Leschziner AE.   +4 more
europepmc   +1 more source

Multiple phases of nucleosomes in the hsp 70 genes of Drosophila melanogaster

, 1980
Abraham Levy, Markus Noll
openalex   +2 more sources