Results 1 to 10 of about 6,681 (209)
The combined effect of environmental and host factors on the emergence of viral RNA recombinants. [PDF]
PLoS Pathogens, 2010 Viruses are masters of evolution due to high frequency mutations and genetic recombination. In spite of the significance of viral RNA recombination that promotes the emergence of drug-resistant virus strains, the role of host and environmental factors in
Hannah M Jaag, Peter D Nagy
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Biologia Plantarum, 2021 Nucleotides are the basic elements of the genetic material, participate in bio-energetic processes, are cofactors and components of secondary metabolites, etc. Nucleotide hydrolases (nucleotidases) are phosphatases that remove the 5'-phosphate group from
G. GALVEZ-VALDIVIESO +3 more
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E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities
Frontiers in Cellular and Infection Microbiology, 2021 Belonging to the GDA1/CD39 protein superfamily, nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of ATP and ADP to the monophosphate form (AMP) and inorganic phosphate (Pi).
Lisvane Paes-Vieira +3 more
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Nature, 1952 REIS1–4 has demonstrated the presence of a phosphatase in various tissues specifically hydrolysing 5-nucleotides, for example, adenosine-5-phosphate. One of us has previously reported5 that normal blood serum has a low 5-nucleotidase activity corresponding to about 1/10 of its non-specific alkaline phosphatase activity towards glycerophosphate. In bone
T F, DIXON, M, PURDON
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Identification, Heterologous Expression, and Functional Characterization of Bacillus subtilis YutF, a HAD Superfamily 5'-Nucleotidase with Broad Substrate Specificity. [PDF]
PLoS ONE, 2016 5'-nucleotidases (EC 3.1.3.5) catalyze the hydrolytic dephosphorylation of 5'-ribonucleotides and 5'-deoxyribonucleotides as well as complex nucleotides, such as uridine 5'-diphosphoglucose (UDP-glucose), nicotinamide adenine dinucleotide and flavin ...
Natalia P Zakataeva +5 more
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Translational Psychiatry, 2021 Cytosolic 5′-nucleotidases II (cNT5-II) are an evolutionary conserved family of 5′-nucleotidases that catalyze the intracellular hydrolysis of nucleotides.
Euginia L. Singgih +5 more
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Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive mucosal lesions.
Pauline M Leite +12 more
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PLoS Computational Biology, 2020 Nucleotides comprise small molecules that perform critical signaling roles in biological systems. Adenosine-based nucleotides, including adenosine tri-, di-, and mono-phosphate, are controlled through their rapid degradation by diphosphohydrolases and ...
Hadi Rahmaninejad +4 more
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Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. [PDF]
PLoS ONE, 2013 Tenofovir (TFV) has been widely used for pre-exposure prophylaxis of HIV-1 infection with mixed results. While the use of TFV in uninfected individuals for prevention of HIV-1 acquisition is actively being investigated, the possible consequences of TFV ...
Nabanita Biswas +6 more
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Transcriptional and Metabolic Investigation in 5′-Nucleotidase Deficient Cancer Cell Lines
Cells, 2021 Enzymes of nucleoside and nucleotide metabolism regulate important cellular processes with potential impacts on nucleotide-unrelated parameters. We have used a set of CRISPR/Cas9-modified cell models expressing both, one, or none of the 5′-nucleotidases ...
Octavia Cadassou +9 more
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