Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner [PDF]
Metabolites, 2022 Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz +4 more
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Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases [PDF]
Frontiers in Physiology, 2022 Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many cell ...
Mafalda S. L. Aresta Branco +4 more
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Effects of physical exercise on the functionality of human nucleotidases: A systematic review [PDF]
Physiological Reports, 2022 Nucleotidases contribute to the regulation of inflammation, coagulation, and cardiovascular activity. Exercise promotes biological adaptations, but its effects on nucleotidase activities and expression are unclear.
Cesar Eduardo Jacintho Moritz +5 more
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Assessment of adenosinergic activity of small extracellular vesicles in plasma of cancer patients and healthy donors [PDF]
OncoImmunologyThe adenosinergic pathway converting endogenous ATP to adenosine (ADO) is a major immunosuppressive pathway in cancer. Emerging data indicate that plasma small extracellular vesicles (sEV) express CD39 and CD73 and produce ADO.
Chang Sook Hong +4 more
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Streptococcus suis 5’-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model [PDF]
VirulenceStreptococcus suis (S. suis) is an important swine bacterial pathogen and causes human infections, leading to a wide range of diseases. However, the role of 5’-nucleotidases in its virulence remains to be fully elucidated. Herein, we identified four cell
Simin Deng +12 more
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Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation [PDF]
mBioThe fission yeast PHO regulon genes pho1, pho84, and tgp1—encoding a cell surface-associated acid phosphatase (Pho1), a plasma membrane inorganic phosphate transporter (Pho84), and a plasma membrane glycerophosphocholine transporter (Tgp1)—are strongly ...
Aleksei Innokentev +4 more
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Purinergic Signaling in Pathologic Osteogenic Differentiation of Aortic Valve Interstitial Cells from Patients with Aortic Valve Calcification [PDF]
Biomedicines, 2023 Purinergic signaling is associated with a vast spectrum of physiological processes, including cardiovascular system function and, in particular, its pathological calcifications, such as aortic valve stenosis.
Polina Klauzen +4 more
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Life, 2021 (1) Background: Acupuncture (AP) is a safe and effective analgesic therapy. Understanding how fine needles trigger biological signals can help us optimize needling manipulation to improve its efficiency.
Yawen Zheng +7 more
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Spatial mapping of ectonucleotidase gene expression in the murine urinary bladder
Frontiers in Physiology, 2023 Purinergic signaling is important for normal bladder function, as it is thought to initiate the voiding reflex and modulate smooth muscle tone. The availability of adenine nucleotides and nucleosides (aka purines) at receptor sites of various cell types ...
Mafalda S. L. Aresta Branco +2 more
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Journal of Bacteriology, 1963 Kohn , J. (Queen Mary's Hospital, London, England) and J. L. Reis . Bacterial nucleotidases. J. Bacteriol. 86: 713–716. 1963.—The 3- and 5- nucleotidase activity in various bacterial species was investigated.
J, KOHN, J L, REIS
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