Results 21 to 30 of about 6,681 (209)
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts. [PDF]
PLoS ONE, 2013 The use of topical and oral adenosine derivatives in HIV prevention that need to be maintained in tissues and cells at effective levels to prevent transmission prompted us to ask whether estradiol could influence the regulation of catabolic nucleotidase ...
Zheng Shen +7 more
doaj +1 more source
Neurobiology of Disease, 2021 Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR).
Elisabete Augusto +11 more
doaj +1 more source
Some aspects of purinergic signaling in the ventricular system of porcine brain
Acta Veterinaria Scandinavica, 2011 Background Numerous signaling pathways function in the brain ventricular system, including the most important - GABAergic, glutaminergic and dopaminergic signaling. Purinergic signalization system - comprising nucleotide receptors, nucleotidases, ATP and
Komoszyński Michał +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann +23 more
wiley +2 more sources
PLoS ONE, 2019 5'-nucleotidases are widespread among all domains of life. The enzymes hydrolyze phosphate residues from nucleotides and nucleotide derivatives. In some pathobiontic bacteria, 5'-nucleotidases contribute to immune evasion by dephosphorylating adenosine ...
Marcel-Lino Dangel +6 more
doaj +1 more source
Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors [PDF]
Royal Society Open Science, 2018 Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling.
Sidra Hassan +7 more
doaj +1 more source
Infection of Human Macrophages by Leishmania infantum Is Influenced by Ecto-Nucleotidases
Frontiers in Immunology, 2018 Ecto-nucleotidase activity is involved in the infection process of Leishmania and various other parasites that enables modulation of host immune responses to promote disease progression.
Nalu Teixeira de Aguiar Peres +10 more
doaj +1 more source
Frontiers in Immunology, 2019 Tumor microenvironments are rich in extracellular nucleotides that can be metabolized by ectoenzymes to produce adenosine, a nucleoside involved in controlling immune responses.
Alberto L. Horenstein +6 more
doaj +1 more source
Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP.
PLoS ONE, 2014 5'-nucleotidases catalyze the hydrolytic dephosphorylation of nucleoside monophosphates. As catabolic enzymes they contribute significantly to the regulation of cellular nucleotide levels; misregulation of nucleotide metabolism and nucleotidase ...
Thomas Monecke +4 more
doaj +1 more source