Results 1 to 10 of about 2,769,148 (383)
Minimap2: pairwise alignment for nucleotide sequences [PDF]
Bioinform., 2017 Motivation Recent advances in sequencing technologies promise ultra-long reads of ∼100 kb in average, full-length mRNA or cDNA reads in high throughput and genomic contigs over 100 Mb in length.
Heng Li
semanticscholar +3 more sources
HyenaDNA: Long-Range Genomic Sequence Modeling at Single Nucleotide Resolution [PDF]
Neural Information Processing Systems, 2023 Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome ...
Eric D Nguyen +12 more
semanticscholar +1 more source
The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto +3 more
doaj +1 more source
Animals, 2021 The positive effects of nucleotide (NU) supplementation in milk replacer have been elucidated in infants and in dairy calves; however, NU addition to whole milk has not been evaluated previously. This study aimed to assess NU supplementation in the whole
Yousef Abbaslou +5 more
doaj +1 more source
Microbial Cell, 2023 The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (viru-lence).
Paulina Katarzyna Grucela +4 more
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Frontiers in Environmental Science, 2022 Nucleic acid derived organic phosphorus (Po) is an important source of plant available P when degraded to inorganic phosphate (P(V)i). It is known that when nucleic acids or components are adsorbed on mineral surfaces, the enzymatic degradation is ...
Sudipta Rakshit +3 more
doaj +1 more source
Molecules, 2021 Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing ...
Joanna M. Watt +2 more
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N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling
Frontiers in Immunology, 2022 Toll-like receptors (TLRs) play critical roles in the first line of host defense against pathogens through recognition of pathogen-associated molecular patterns and initiation of the innate immune responses.
Hyun-Sup Song +10 more
doaj +1 more source
Nucleotide metabolism: a pan-cancer metabolic dependency
Nature Reviews. Cancer, 2023 Overactive nucleotide synthesis is a hallmark of cancers and inhibitors of nucleotide synthesis pathways have shown promise in some cancer types. In this Review, Mullen and Singh give an overview of the role of aberrant nucleotide synthesis in supporting
Nick Mullen, Pankaj K Singh
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Angewandte Chemie International Edition, 2011 DNA as an information storage system is simple and at the same time complex owing to the various different arrangements of the four natural nucleotides.[1] The DNA synthesis by DNA polymerases is intriguing, since these enzymes are able to catalyze the elongation of the primer strand by recognizing the DNA template and selecting the corresponding ...
Baccaro, Anna +2 more
openaire +3 more sources