Results 1 to 10 of about 2,047,681 (342)

The Intersection of Purine and Mitochondrial Metabolism in Cancer

open access: yesCells, 2021
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto   +3 more
doaj   +1 more source

Molecular analysis of ompA gene Pasteurella multocida Indonesia local isolates [PDF]

open access: yesIraqi Journal of Veterinary Sciences, 2020
The aim of this research was to analyze ompA molecular gene of Pasteurella multocida buffalo isolate and bovine isolate from Nusa Tenggara Timur, Indonesia and Katha strain isolate from hemorrhagic septicemia vaccine. Determinant of P.
A. T. Soelih Estoepangestie   +5 more
doaj   +1 more source

Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications

open access: yesPharmaceutics, 2023
The use of nucleotides for biomedical applications is an old desire in the scientific community. As we will present here, there are references published over the past 40 years with this intended use.
Camila Magalhães Cardador   +7 more
doaj   +1 more source

A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in Trypanosoma brucei

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
Maintenance of dNTPs pools in Trypanosoma brucei is dependent on both biosynthetic and degradation pathways that together ensure correct cellular homeostasis throughout the cell cycle which is essential for the preservation of genomic stability. Both the
Pablo Antequera-Parrilla   +4 more
doaj   +1 more source

Stimuli-Responsive Nucleotide–Amino Acid Hybrid Supramolecular Hydrogels

open access: yesGels, 2021
The ability to assemble chemically different gelator molecules into complex supramolecular hydrogels provides excellent opportunities to construct functional soft materials.
Matthew Mulvee   +3 more
doaj   +1 more source

Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

open access: yesPharmaceuticals, 2022
Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted inhibition of VWF induces thrombolysis when administered in vivo in animal models of ischemic stroke.
Susan M. Shea   +7 more
doaj   +1 more source

Evolutionary degeneration of septins into pseudoGTPases: impacts on a hetero-oligomeric assembly interface

open access: yesFrontiers in Cell and Developmental Biology, 2023
The septin family of eukaryotic proteins comprises distinct classes of sequence-related monomers that associate in a defined order into linear hetero-oligomers, which are capable of polymerizing into cytoskeletal filaments. Like actin and ⍺ and β tubulin,
Alya Hussain   +3 more
doaj   +1 more source

Renalase – a new instrument in multicomponent heart failure assessment

open access: yesKlinicist, 2022
Heart failure (HF) remains a serious problem in Russian and world health care due to the growing morbidity and mortality from complications of heart failure, despite the development and implementation of programs for the early detection and treatment of ...
A. M. Alieva   +5 more
doaj   +1 more source

Barcoded Nucleotides [PDF]

open access: yesAngewandte Chemie International Edition, 2011
DNA as an information storage system is simple and at the same time complex owing to the various different arrangements of the four natural nucleotides.[1] The DNA synthesis by DNA polymerases is intriguing, since these enzymes are able to catalyze the elongation of the primer strand by recognizing the DNA template and selecting the corresponding ...
Baccaro, Anna   +2 more
openaire   +3 more sources

Exploring the nucleotide molecular mechanism of compound kushen injection for lung adenocarcinoma based on network pharmacology and molecular docking

open access: yesFrontiers in Oncology, 2022
Compound kushen injection is an effective traditional Chinese medicine for the treatment of lung cancer. However, its influence on the survival and prognosis of patients with lung adenocarcinoma patients was less studied; especially its pharmacological ...
Zhangpeng Ye   +9 more
doaj   +1 more source

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