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The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto +3 more
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Animals, 2021 The positive effects of nucleotide (NU) supplementation in milk replacer have been elucidated in infants and in dairy calves; however, NU addition to whole milk has not been evaluated previously. This study aimed to assess NU supplementation in the whole
Yousef Abbaslou +5 more
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Microbial Cell, 2023 The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (viru-lence).
Paulina Katarzyna Grucela +4 more
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Frontiers in Environmental Science, 2022 Nucleic acid derived organic phosphorus (Po) is an important source of plant available P when degraded to inorganic phosphate (P(V)i). It is known that when nucleic acids or components are adsorbed on mineral surfaces, the enzymatic degradation is ...
Sudipta Rakshit +3 more
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Molecules, 2021 Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing ...
Joanna M. Watt +2 more
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N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling
Frontiers in Immunology, 2022 Toll-like receptors (TLRs) play critical roles in the first line of host defense against pathogens through recognition of pathogen-associated molecular patterns and initiation of the innate immune responses.
Hyun-Sup Song +10 more
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Angewandte Chemie International Edition, 2011 DNA as an information storage system is simple and at the same time complex owing to the various different arrangements of the four natural nucleotides.[1] The DNA synthesis by DNA polymerases is intriguing, since these enzymes are able to catalyze the elongation of the primer strand by recognizing the DNA template and selecting the corresponding ...
Baccaro, Anna +2 more
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Biology, 2020 Machine learning algorithms can learn mechanisms of antimicrobial resistance from the data of DNA sequence without any a priori information. Interpreting a trained machine learning algorithm can be exploited for validating the model and obtaining new ...
Taha ValizadehAslani +3 more
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Agreement of aptamer proteomics with standard methods for measuring venous thrombosis biomarkers
Research and Practice in Thrombosis and Haemostasis, 2021 Background Venous thromboembolism (VTE) is a complex disease with an incidence rate of about 1 in 1000 per year. Despite the availability of validated biomarkers for VTE, unprovoked events account for 50% of first events.
Tariq Faquih +5 more
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Stimuli-Responsive Nucleotide–Amino Acid Hybrid Supramolecular Hydrogels
Gels, 2021 The ability to assemble chemically different gelator molecules into complex supramolecular hydrogels provides excellent opportunities to construct functional soft materials.
Matthew Mulvee +3 more
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