Results 1 to 10 of about 1,659,556 (372)

The Intersection of Purine and Mitochondrial Metabolism in Cancer

open access: yesCells, 2021
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto   +3 more
doaj   +1 more source

N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling

open access: yesFrontiers in Immunology, 2022
Toll-like receptors (TLRs) play critical roles in the first line of host defense against pathogens through recognition of pathogen-associated molecular patterns and initiation of the innate immune responses.
Hyun-Sup Song   +10 more
doaj   +1 more source

Influence of Citrate and Phosphate on the Adsorption of Adenosine-5′-Monophosphate at the Hematite Water Interface

open access: yesFrontiers in Environmental Science, 2022
Nucleic acid derived organic phosphorus (Po) is an important source of plant available P when degraded to inorganic phosphate (P(V)i). It is known that when nucleic acids or components are adsorbed on mineral surfaces, the enzymatic degradation is ...
Sudipta Rakshit   +3 more
doaj   +1 more source

Minimap2: pairwise alignment for nucleotide sequences [PDF]

open access: yesBioinform., 2017
Motivation Recent advances in sequencing technologies promise ultra-long reads of ∼100 kb in average, full-length mRNA or cDNA reads in high throughput and genomic contigs over 100 Mb in length.
Heng Li
semanticscholar   +1 more source

Nucleotide Supplementation to Whole Milk Has Beneficial Effects on Post-Weaning Holstein Calf Performance

open access: yesAnimals, 2021
The positive effects of nucleotide (NU) supplementation in milk replacer have been elucidated in infants and in dairy calves; however, NU addition to whole milk has not been evaluated previously. This study aimed to assess NU supplementation in the whole
Yousef Abbaslou   +5 more
doaj   +1 more source

Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?

open access: yesMicrobial Cell, 2023
The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (viru-lence).
Paulina Katarzyna Grucela   +4 more
doaj   +1 more source

Light–Nucleotide versus Ion–Nucleotide Interactions for Single-Nucleotide Resolution

open access: yesThe Journal of Physical Chemistry B, 2021
Several parallel reads of ionic currents through multiple CsgG nanopores provide information about ion-nucleotide interactions for sequencing single-stranded DNA (ss-DNA) using base-calling algorithms. However, the information in ion-nucleotide interactions seems insufficient for single-read nanopore DNA sequencing.
Mohsen Farshad, Jayendran C. Rasaiah
openaire   +4 more sources

Molecular analysis of ompA gene Pasteurella multocida Indonesia local isolates [PDF]

open access: yesIraqi Journal of Veterinary Sciences, 2020
The aim of this research was to analyze ompA molecular gene of Pasteurella multocida buffalo isolate and bovine isolate from Nusa Tenggara Timur, Indonesia and Katha strain isolate from hemorrhagic septicemia vaccine. Determinant of P.
A. T. Soelih Estoepangestie   +5 more
doaj   +1 more source

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

open access: yesMolecules, 2021
Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing ...
Joanna M. Watt   +2 more
doaj   +1 more source

Agreement of aptamer proteomics with standard methods for measuring venous thrombosis biomarkers

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2021
Background Venous thromboembolism (VTE) is a complex disease with an incidence rate of about 1 in 1000 per year. Despite the availability of validated biomarkers for VTE, unprovoked events account for 50% of first events.
Tariq Faquih   +5 more
doaj   +1 more source

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