Results 41 to 50 of about 2,769,148 (383)

Vitamin E Phosphate Nucleoside Prodrugs: A Platform for Intracellular Delivery of Monophosphorylated Nucleosides

Pharmaceuticals, 2018
Vitamin E phosphate (VEP) nucleoside prodrugs are designed to bypass two mechanisms of tumor resistance to therapeutic nucleosides: nucleoside transport and kinase downregulation.
Richard Daifuku, Michael Koratich, Murray Stackhouse   +2 more
doaj   +1 more source

SHMT2 is essential for mammalian preimplantation embryonic development through de novo biosynthesis of nucleotide metabolites

Molecular Therapy: Nucleic Acids
Assisted reproductive technology (ART) is used widely and efficiently to treat infertility. During the ART procedure, one of the main factors affecting the success rate is abnormal development of preimplantation embryos. The establishment and maintenance
Mingze Shi, Yingxue Huai, Tiantian Deng, Chuanxin Zhang, Jinzhu Song, Jiawei Wang, Yiwen Zhang, Zi-Jiang Chen, Han Zhao, Keliang Wu, Boyang Liu   +10 more
doaj   +1 more source

Inclusion of yeast-derived protein in weanling diet improves growth performance, intestinal health, and anti-oxidative capability of piglets

Czech Journal of Animal Science, 2014
The effects of yeast-derived protein (YP) on growth performance, intestinal health, and oxidative status of weanling piglets were investigated. A total of 80 weaned piglets (PIC 327 × 1050, 26 ± 2 days old, 6.20 ± 0.10 kg) were randomly allocated into 2 ...
L. Hu, L. Che, G. Su, Y. Xuan, G. Luo, F. Han, Y. Wu, G. Tian, C. Wu, Z. Fang, Y. Lin, S. Xu, D. Wu   +12 more
doaj   +1 more source

Sensory taste properties of chicken (Hy-Line brown) soup as prepared with five different parts of the chicken

International Journal of Food Properties, 2020
Taste is one of the main chicken soup characteristic quality factors as it affects palatability as well as consumer acceptability. Metabolomics coupled with sensory analysis method were applied to explore the differences of taste-chemical compositions in
Lili Zhang, Wen Duan, Yan Huang, Yuyu Zhang, Baoguo Sun, Dandan Pu, Yizhuang Tang, Chao Liu   +7 more
doaj   +1 more source

Deblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns

mSystems, 2017
Deblur provides a rapid and sensitive means to assess ecological patterns driven by differentiation of closely related taxa. This algorithm provides a solution to the problem of identifying real ecological differences between taxa whose amplicons differ ...
Amnon Amir, Daniel McDonald, Jose A Navas-Molina, Evguenia Kopylova, James T. Morton, Zhenjiang Zech Xu, E. Kightley, Luke R. Thompson, Embriette R. Hyde, Antonio Gonzalez, R. Knight   +10 more
semanticscholar   +1 more source

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. [PDF]

, 2008
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients.
Hawinkels, LJAC, Hommes, DW, Kubben, FJGM, Lamers, CBHW, Langers, AMJ, Sier, CFM, van der Reijden, JJ, van Duijn, W, Verspaget, HW   +8 more
core   +2 more sources

Morpholino–RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection

Nature Communications
Intrathecal injection of steric-block antisense oligonucleotides (ASOs) provides therapeutic opportunities for targeting the central nervous system (CNS).
Mitsugu Yanagidaira, Tetsuya Nagata, Juri Hasegawa, Takashi Ishii, Satoe Ebihara, Makiko Nawa, Takanori Yokota   +6 more
doaj   +1 more source

Functional Characterization of the Saccharomyces cerevisiae Equilibrative Nucleoside Transporter 1 (ScENT1)

Molecules, 2018
Equilibrative nucleoside transporters (ENTs) are polytopic membrane transporters responsible for the translocation of nucleosides, nucleobases—to a lesser extent—and nucleoside analog therapeutics across cellular membranes.
Rebba C. Boswell-Casteel, Jennifer M. Johnson, Franklin A. Hays   +2 more
doaj   +1 more source

Detection of Single Nucleotide Polymorphism Rs2013162 of IRF6 Gene in Patient with Cleft Lip and Palate [PDF]

, 2019
Background: Cleft lip and palate are congenital disorders which induce affected individuals medically, socially and psychologically. The objective of this study was to investigate the association of Single Nucleotide Polymorphism(SNP); rs2013162 of ...
Shehzad, H. (Husnain), Shehzad, O. (Osheen)   +1 more
core  

MODULATION OF THE CGMP-GATED CHANNEL BY CALCIUM [PDF]

, 1995
Calcium acting through calmodulin has been shown to regulate the affinity of cyclic nucleotide-gated channels expressed in cell lines.
LAGNADO, L, SAGOO, MS
core   +1 more source