Results 41 to 50 of about 2,047,681 (342)

The European Nucleotide Archive [PDF]

Nucleic Acids Research, 2010
The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena) is Europe's primary nucleotide-sequence repository. The ENA consists of three main databases: the Sequence Read Archive (SRA), the Trace Archive and EMBL-Bank. The objective of ENA is to support and promote the use of nucleotide sequencing as an experimental research platform by providing ...
Richard Gibson, Ewan Birney, Gemma Hoad, Ruth Akhtar, Neil Goodgame, Siamak Sobhany, Iain Cleland, Sheila Plaister, Mikyung Jang, Robert Vaughan, Nima Pakseresht, Guy Cochrane, Lawrence Bower, Vadim Zalunin, Ying Cheng, Petra ten Hoopen, Kethi Reddy, Ana Cerdeño-Tárraga, Rajesh Radhakrishnan, Nadeem Faruque, Rasko Leinonen   +20 more
openaire   +3 more sources

Nucleotide Supplementation to Whole Milk Has Beneficial Effects on Post-Weaning Holstein Calf Performance

Animals, 2021
The positive effects of nucleotide (NU) supplementation in milk replacer have been elucidated in infants and in dairy calves; however, NU addition to whole milk has not been evaluated previously. This study aimed to assess NU supplementation in the whole
Yousef Abbaslou, Davood Zahmatkesh, Ehsan Mahjoubi, Mehdi Hossein Yazdi, Hamed Beiranvand, Morteza Gorjidooz   +5 more
doaj   +1 more source

Detection of Single Nucleotide Polymorphism Rs2013162 of IRF6 Gene in Patient with Cleft Lip and Palate [PDF]

, 2019
Background: Cleft lip and palate are congenital disorders which induce affected individuals medically, socially and psychologically. The objective of this study was to investigate the association of Single Nucleotide Polymorphism(SNP); rs2013162 of ...
Shehzad, H. (Husnain), Shehzad, O. (Osheen)   +1 more
core  

Statistical distributions of sequencing by synthesis with probabilistic nucleotide incorporation

, 2014
Sequencing by synthesis is used in many next-generation DNA sequencing technologies. Some of the technologies, especially those exploring the principle of single-molecule sequencing, allow incomplete nucleotide incorporation in each cycle.
Kong, Yong
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]

, 2012
Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian, Lawford, Bruce, Morris, Phillip, Swagell, Christopher, Voisey, Joanne, Young, Ross   +5 more
core   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Agreement of aptamer proteomics with standard methods for measuring venous thrombosis biomarkers

Research and Practice in Thrombosis and Haemostasis, 2021
Background Venous thromboembolism (VTE) is a complex disease with an incidence rate of about 1 in 1000 per year. Despite the availability of validated biomarkers for VTE, unprovoked events account for 50% of first events.
Tariq Faquih, Dennis O. Mook‐Kanamori, Frits R. Rosendaal, Trevor Baglin, Ko Willems van Dijk, Astrid vanHylckama Vlieg   +5 more
doaj   +1 more source

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Molecules, 2021
Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing ...
Joanna M. Watt, Richard Graeff, Barry V. L. Potter   +2 more
doaj   +1 more source

Molecular and morphometric variation in European populations of the articulate brachiopod Terebeatulina retusa [PDF]

, 1993
Molecular and morphometric variation within and between population samples of the articulate brachiopod <i>Terebratulina</i> spp., collected in 1985-1987 from a Norwegian fjord, sea lochs and costal sites in western Scotland, the southern ...
A. C. Wilson, A. Logan, B. L. Cohen, B. Manly, C. A. Reeb, C. H. Brunton, C. S. Baker, E. S. Balakirev, E. S. Morse, F. J. Ayala, G. B. Curry, G. B. Curry, G. R. Webb, H. McCammon, H. T. Jacobs, I. I. Wirgin, J. C. Avise, J. C. Avise, J. C. Avise, J. C. Millr, J. D. Milliman, J. D. Peacock, J. E. Graves, J. P. A. Noble, J. W. Valentine, J. W. Valentine, L. Vawter, M. J. S. Rudwick, M. Nei, M. Nei, M. Nei, Marine Biological Association, U.K., N.-A. Morner, R. R. Sokal, T. Davidson, W. H. Dall   +35 more
core   +1 more source