Results 231 to 240 of about 621,729 (284)

Spatial transcriptome and single-cell reveal the role of nucleotide metabolism in colorectal cancer progression and tumor microenvironment. [PDF]

J Transl Med
Liu J, Li H, Wang L, Wang S, Tang Q.
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Lifespan Extension by Retrotransposons under Conditions of Mild Stress Requires Genes Involved in tRNA Modifications and Nucleotide Metabolism. [PDF]

Int J Mol Sci
Maxwell PH, Mahmood M, Villanueva M, Devine K, Avery N.   +4 more
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans. [PDF]

PLoS Biol
Yanagi KS, Jochim B, Kunjo SO, Breen P, Ruvkun G, Lehrbach N.   +5 more
europepmc   +1 more source

SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis. [PDF]

Cell Rep
Tucker SA, Hu SH, Vyas S, Park A, Joshi S, Inal A, Lam T, Tan E, Haigis KM, Haigis MC.   +9 more
europepmc   +1 more source

Integration of mult-omics and nucleotide metabolism reprogramming signature analysis reveals gastric cancer immunological and prognostic features. [PDF]

Cancer Cell Int
Chen S, Wang Z.
europepmc   +1 more source

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Dihydropyrimidine nucleotide metabolism

Archives of Biochemistry and Biophysics, 1957
Abstract 5,6-Dihydrouridine-phosphates-C 14 were prepared by catalytic reduction of uridine 2′- and 3′-phosphates with the use of a rhodium catalyst. An electrolytic method for the reduction of cytidine 2′- and 3′-phosphates was developed for the preparation of 5,6-dihydrocytidylic acid. Neither of the dihydropyrimidine nucleotides was incorporated
D W, VISSER, D, VAN PRAAG, T K, FUKUHARA
openaire   +2 more sources

Nucleotide Metabolism by Endothelium

Annual Review of Physiology, 1985
Synthese bibliographique etablie surtout a partir de travaux sur culture de cellules ...
J D, Pearson, J L, Gordon
openaire   +3 more sources