Results 161 to 170 of about 878,332 (327)
Разработка и регистрация лекарственных средств, 2019 The article presents information on the structure, classification and functions of NO-synthases. The main inhibitors of the enzyme, as well as their mechanisms of action, are considered. Among the substances activating the activity of the enzyme, special
E. S. Kokareva +6 more
doaj
The Acid-soluble Nucleotides of Barley and Oat Plants. [PDF]
, 1957 Rolf Bergkvist +6 more
openalex +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW)
Разработка и регистрация лекарственных средств, 2019 The paper presents an overview of the structure and functions of caspase group enzymes. The main stages and ways of development of programmed cell death - apoptosis were demonstrated.
E. S. Kokareva +4 more
doaj
Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
Advanced Functional Materials, EarlyView.This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer +10 more
wiley +1 more source
Nucleotide dependency analysis of genomic language models detects functional elements. [PDF]
Nat GenetTomaz da Silva P +7 more
europepmc +1 more source
Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
Advanced Functional Materials, EarlyView.This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson +12 more
wiley +1 more source