Results 41 to 50 of about 849,646 (371)

Cryptic Variation in the Human Mutation Rate [PDF]

open access: yes, 2009
The mutation rate is known to vary between adjacent sites within the human genome as a consequence of context, the most well-studied example being the influence of CpG dinucelotides.
Eyre-Walker, Adam   +2 more
core   +3 more sources

Physiological and Metabolic Responses of Leymus chinensis Seedlings to Alkali Stress

open access: yesPlants, 2022
To elucidate the physiological and metabolic mechanism of perennial grass responses to alkali stress, we selected Leymus chinensis (L. chinensis), a salt-tolerant perennial rhizomatous species of the family Poaceae as experimental material.
Ge Yan   +4 more
doaj   +1 more source

Impact of Tandem Repeats on the Scaling of Nucleotide Sequences [PDF]

open access: yes, 2005
Techniques such as detrended fluctuation analysis (DFA) and its extensions have been widely used to determine the nature of scaling in nucleotide sequences. In this brief communication we show that tandem repeats which are ubiquitous in nucleotide sequences can prevent reliable estimation of possible long-range correlations.
arxiv   +1 more source

The First 5′-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral Evaluation

open access: yesMolecules, 2022
A series of 5′-phosphorylated (dialkyl phosphates, diaryl phosphates, phosphoramidates, H-phosphonates, phosphates) 1,2,3-triazolyl nucleoside analogues in which the 1,2,3-triazole-4-yl-β-D-ribofuranose fragment is attached via a methylene group or a ...
Dmitry A. Tatarinov   +12 more
doaj   +1 more source

A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias [PDF]

open access: yes, 2017
CONTEXT: This paper reports on the results of treatment of compressive neuralgia using a combination of nucleotides (uridine triphosphate trisodium [UTP] and cytidine monophosphate disodium [CMP]) and vitamin B(12).
Buchman, Luiz   +9 more
core   +2 more sources

New Strategy to Preserve Phosphate by Ionic Liquid Matrices in Matrix-Assisted Laser Desorption/Ionization: A Case of Adenosine Nucleotides

open access: yesMolecules, 2020
Adenosine -5′-triphosphate (ATP) plays a valuable role in metabolic activity to produce adequate energy in a biosystem. A high ATP/AMP ratio has a correlation with diabetes that induces suppression of AMP-activated protein kinase (AMPK).
Chih-Hao Lin   +3 more
doaj   +1 more source

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

open access: yesMicroorganisms, 2021
Leishmaniasis is an emerging, uncontrolled, and neglected zoonotic disease. Climate change is contributing to its ongoing global expansion. The dog is the main reservoir; hence the importance of implementing effective treatment, prevention, and control ...
Sergi Segarra
doaj   +1 more source

The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters [PDF]

open access: yes, 2014
The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitochondrial carrier family, many of which have been shown to transport inorganic anions, amino acids, carboxylates, nucleotides, and coenzymes across the inner
Agrimi, G.   +6 more
core   +2 more sources

Purine Nucleotides in the Regulation of Brown Adipose Tissue Activity

open access: yesFrontiers in Endocrinology, 2020
Non-shivering thermogenesis in mammalian brown adipose tissue is a powerful mechanism to defend normothermia in cold climates. To minimize the loss of chemical energy, the central functional component, mitochondrial uncoupling protein 1, UCP1, must be ...
Andrea Bast-Habersbrunner   +3 more
doaj   +1 more source

Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis

open access: yesAntioxidants, 2023
Inclusion body myositis (IBM) is an acquired inflammatory myopathy affecting proximal and distal muscles that leads to weakness in patients over 50.
Judith Cantó-Santos   +15 more
doaj   +1 more source

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