Results 91 to 100 of about 2,194,144 (349)

An intracellular arrangement of Histoplasma capsulatum yeast-aggregates generates nuclear damage to the cultured murine alveolar macrophages

Frontiers in Microbiology, 2016
Histoplasma capsulatum is responsible for a human systemic mycosis that primarily affects lung tissue. Macrophages are the major effector cells in humans that respond to the fungus, and the development of respiratory disease depends on the ability of ...
Nayla De Souza Pitangui, Janaina De Cássia Orlandi Sardi, Aline Raquel eVoltan, Claudia Tavares edos Santos, Julhiany De Fátima Da Silva, Rosângela Aparecida Moraes da Silva, Felipe Oliveira Souza, Christiane Pienna Soares, Gabriela eRodríguez-Arellanes, Maria Lúcia Taylor, Maria José Soares Mendes-Giannini, Ana Marisa eFusco-Almeida   +11 more
doaj   +1 more source

Comparison of potential models of nucleus-nucleus bremsstrahlung

, 2014
At low photon energies, the potential models of nucleus-nucleus bremsstrahlung are based on electric transition multipole operators, which are derived either only from the nuclear current or only from the charge density by making the long-wavelength ...
Baye, Daniel, Dohet-Eraly, Jérémy
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Regulation of nuclear transcription by mitochondrial RNA in endothelial cells

eLife
Chromatin-associated RNAs (caRNAs) form a relatively poorly recognized layer of the epigenome. The caRNAs reported to date are transcribed from the nuclear genome.
Kiran Sriram, Zhijie Qi, Dongqiang Yuan, Naseeb Kaur Malhi, Xuejing Liu, Riccardo Calandrelli, Yingjun Luo, Alonso Tapia, Shengyan Jin, Ji Shi, Martha Salas, Runrui Dang, Brian Armstrong, Saul J Priceman, Ping H Wang, Jiayu Liao, Rama Natarajan, Sheng Zhong, Zhen Bouman Chen   +18 more
doaj   +1 more source

Subcellular Localization Screening of Colletotrichum higginsianum Effector Candidates Identifies Fungal Proteins Targeted to Plant Peroxisomes, Golgi Bodies, and Microtubules

Frontiers in Plant Science, 2018
The genome of the hemibiotrophic anthracnose fungus, Colletotrichum higginsianum, encodes a large inventory of putative secreted effector proteins that are sequentially expressed at different stages of plant infection, namely appressorium-mediated ...
Guillaume P. Robin, Jochen Kleemann, Ulla Neumann, Lisa Cabre, Jean-Félix Dallery, Nicolas Lapalu, Richard J. O’Connell   +6 more
doaj   +1 more source

Heavy flavors in nucleus-nucleus and proton-nucleus collisions [PDF]

EPJ Web of Conferences, 2016
A multi-step setup for heavy-flavor studies in high-energy nucleus-nucleus (AA) and proton-nucleus (pA) collisions is presented. The propagation of the heavy quarks in the medium is described in a framework provided by the relativistic Langevin equation, here solved using weak-coupling transport coefficients. Successively, the heavy quarks hadronize in
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

cGAS: action in the nucleus

Frontiers in Immunology
As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA
Yikai Lu, Mengmeng Zhao, Li Chen, Yan Wang, Tianhao Liu, Haipeng Liu   +5 more
doaj   +1 more source

Kinds of nucleus for effective pearl cultivation of the pearl oysters, Pinctada fucata [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2007
Seeding is the most important aspect of pearl cultivation, and appropriate nucleus can determine the quality of a pearl : nacre secretion and accumulation around the nucleus.
Kanjanachatree, K., Piyathamrongrut, K., Inthoncharoen, J.   +2 more
doaj  

Deciphering Nuclear Mechanobiology in Laminopathy

Cells, 2019
Extracellular mechanical stimuli are translated into biochemical signals inside the cell via mechanotransduction. The nucleus plays a critical role in mechanoregulation, which encompasses mechanosensing and mechanotransduction.
Jungwon Hah, Dong-Hwee Kim
doaj   +1 more source