Results 91 to 100 of about 1,516,986 (362)

Regulation of nuclear transcription by mitochondrial RNA in endothelial cells

eLife
Chromatin-associated RNAs (caRNAs) form a relatively poorly recognized layer of the epigenome. The caRNAs reported to date are transcribed from the nuclear genome.
Kiran Sriram, Zhijie Qi, Dongqiang Yuan, Naseeb Kaur Malhi, Xuejing Liu, Riccardo Calandrelli, Yingjun Luo, Alonso Tapia, Shengyan Jin, Ji Shi, Martha Salas, Runrui Dang, Brian Armstrong, Saul J Priceman, Ping H Wang, Jiayu Liao, Rama Natarajan, Sheng Zhong, Zhen Bouman Chen   +18 more
doaj   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

cGAS: action in the nucleus

Frontiers in Immunology
As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA
Yikai Lu, Mengmeng Zhao, Li Chen, Yan Wang, Tianhao Liu, Haipeng Liu   +5 more
doaj   +1 more source

suppression from hadron-nucleus to nucleus-nucleus collisions

Nuclear Physics B, 1990
Abstract We explore the combined role of inelastic final-state scattering with nucleons and comoving secondary particles in the suppression of J ψ production for hadron-nucleus and nucleus-nucleus collisions, as functions of target mass, beam energy, and transverse energy.
Ramona Vogt, Sean Gavin
openaire   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Manifold Routes to a Nucleus

Frontiers in Microbiology, 2018
It is widely assumed that there is a clear distinction between eukaryotes, with cell nuclei, and prokaryotes, which lack nuclei. This suggests the evolution of nuclear compartmentation is a singular event.
Heather L. Hendrickson, Anthony M. Poole, Anthony M. Poole, Anthony M. Poole   +3 more
doaj   +1 more source

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

Cell Death and Disease, 2016
Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence.
Deheng Chen, Dongdong Xia, Zongyou Pan, Daoliang Xu, Yifei Zhou, Yaosen Wu, Ningyu Cai, Qian Tang, Chenggui Wang, Mei-Jun Yan, Jing Zhang, Kailiang Zhou, Quan Wang, Yongzeng Feng, Xiangyang Wang, Huazi Xu, Xiaolei Zhang, Naifeng Tian   +17 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Strangeness in ultrarelativistic nucleus-nucleus collisions [PDF]

Nuclear Physics A, 1998
13 pages LaTeX including 6 postscript figures; needs style files espcrc1,floatfig,epsfig. Invited talk presented at 6th International Conference on Nucleus-Nucleus Collisions at Gatlinburg, June 2-6, 1997.
openaire   +3 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source