Results 91 to 100 of about 1,491,280 (348)

Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.

New England Journal of Medicine, 1998
BACKGROUND In many patients with idiopathic Parkinson's disease, treatment with levodopa is complicated by fluctuations between an "off" period, when the medication is not working and the motor symptoms of parkinsonism are present, and an "on" period ...
P. Limousin, P. Krack, P. Pollak, A. Benazzouz, C. Ardouin, D. Hoffmann, A. Benabid   +6 more
semanticscholar   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

suppression from hadron-nucleus to nucleus-nucleus collisions

Nuclear Physics B, 1990
Abstract We explore the combined role of inelastic final-state scattering with nucleons and comoving secondary particles in the suppression of J ψ production for hadron-nucleus and nucleus-nucleus collisions, as functions of target mass, beam energy, and transverse energy.
Ramona Vogt, Sean Gavin
openaire   +2 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

Cell Death and Disease, 2016
Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence.
Deheng Chen, Dongdong Xia, Zongyou Pan, Daoliang Xu, Yifei Zhou, Yaosen Wu, Ningyu Cai, Qian Tang, Chenggui Wang, Mei-Jun Yan, Jing Zhang, Kailiang Zhou, Quan Wang, Yongzeng Feng, Xiangyang Wang, Huazi Xu, Xiaolei Zhang, Naifeng Tian   +17 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Surgical complications and metachronous rectal cancer risk in patients with classic familial adenomatous polyposis

Journal of Coloproctology, 2015
Introduction: Familial adenomatous polyposis (FAP), an autosomal dominant disease characterized by development of numerous adenomatous polyps in the colon and rectum, is caused by germline mutations in the Adenomatous Polyposis Coli (APC) gene.
Paulo Roberto Stevanato Filho, Samuel Aguiar, Jr., Fábio O. Ferreira, Wilson T. Nakagawa, Ranyell M. Spencer, Renata M. Takahashi, Tiago S. Bezerra, Ademar Lopes   +7 more
doaj  

Structures and functions in the crowded nucleus: new biophysical insights

Frontiers in Physics, 2014
Concepts and methods from the physical sciences have catalysed remarkable progress in understanding the cell nucleus in recent years. To share this excitement with physicists and encourage their interest in this field, this review offers an overview of ...
Ronald eHancock
doaj   +1 more source

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease

Nature Genetics, 2021
Samuel Morabito, Emily Miyoshi, Neethu Michael, Saba Shahin, A. Martini, E. Head, Justine Silva, K. Leavy, Mari Perez-Rosendahl, V. Swarup   +9 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source