Results 141 to 150 of about 111,869 (302)

Abstinence from cocaine self-administration promotes microglial pruning of astrocytes, which drives cocaine-seeking behavior

Cell Reports
Summary: Rodent drug self-administration leads to a compromised ability of nucleus accumbens astrocytes to maintain glutamate homeostasis as well as to reductions in surface area, volume, and synaptic colocalization of astrocyte membranes.
Anze Testen, Jonathan W. VanRyzin, Tania J. Bellinger, Ronald Kim, Han Wang, Matthew J. Gastinger, Emily A. Witt, Janay P. Franklin, Haley A. Vecchiarelli, Katherine Picard, Michael D. Scofield, Marie-Ève Tremblay, Kathryn J. Reissner   +12 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Psychotropic medication and the fetal brain

The Journal of Physiology, EarlyView.
Abstract figure legend Brain region changes linked to in‐utero psychotropic exposure. Abstract Medications known to cross the blood–brain barrier (psychotropic medications) are commonly prescribed to women during pregnancy, often for the management of mental illness.
Oliver Gale‐Grant, Tomoki Arichi
wiley   +1 more source

Dystrophinopathy with a DMD exon 49–50 deletion in a female patient who developed schizophrenia: An autopsy case

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Mutations in DMD affect not only muscles but also the brain. Cases of schizophrenia with DMD mutations have been described previously. Although female dystrophinopathy often has a milder phenotype, some affected females also have intellectual disabilities and psychiatric disorders.
Shusei Arafuka, Youta Torii, Ayako Miwa, Itaru Kushima, Hirotaka Sekiguchi, Hiroshige Fujishiro, Chikako Habuchi, Hiroaki Miyahara, Yosuke Kawai, Ran Wei, Katsushi Tokunaga, Norio Ozaki, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda   +15 more
wiley   +1 more source

Pharmacologic MRI Brain Imaging Studies of Serotonin 5‐HT1 Receptor Agonists in Awake Mice

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Serotonin (5‐hydroxytryptamine, 5‐HT) type‐1 G protein‐coupled receptors are expressed throughout the central nervous system. 5‐HT1AR activation is the putative mechanism of approved drugs for generalized anxiety disorder and major depressive disorder and is being studied in the treatment of autism and neurological disorders.
Brittany M. Brems, Erin E. Sullivan, Ryan P. McGlynn, Praveen Kulkarni, Craig F. Ferris, Raymond G. Booth   +5 more
wiley   +1 more source

Assessing Age‐Associated Influences on Paramagnetic and Diamagnetic Susceptibility Maps in Postmortem Human Brains

NMR in Biomedicine, Volume 39, Issue 5, May 2026.
We applied the APART‐QSM method to in situ postmortem MRI from 47 subjects (31–91 years) to assess age effects on paramagnetic and diamagnetic susceptibility. Diamagnetic susceptibility declined with age in basal ganglia, possibly reflecting shared biological factors.
José Henrique Monteiro de Azevedo, Maria Concepción Garcia Otaduy, Andre Avanzine, Roberta Diehl Rodriguez, Fábio Seiji Otsuka, Fernando Barbosa Jr., Chunlei Liu, Carlos Ernesto Garrido Salmon   +7 more
wiley   +1 more source

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization

Addiction Biology, Volume 31, Issue 5, May 2026.
This study employed integrative Mendelian Randomization analysis to identify 10 drug‐targetable genes with altered expression in alcohol dependence. Colocalization evidence suggests shared causal variants. Crucially, DNA methylation at specific sites (cg07437263, cg05102552) mediates risk by upregulating the protective gene CDK5R1 (63.92%) and ...
Fuyuan Deng, Junsheng Peng, Siran Lai, Guangpeng Zhang, Miaomiao Li, Yuxin Huang, Mi Yuan, Gaolei Yao, Peiming Zhang, Liming Lu   +9 more
wiley   +1 more source

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study

Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez, Abraham Bailén Torregrosa, Francisco Navarrete, Auxiliadora Aracil‐Fernández, Gabriel Rubio, Jorge Manzanares   +5 more
wiley   +1 more source