Results 141 to 150 of about 72,699 (283)

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

The Journal of Physiology, EarlyView.
Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg, Pieter Nicolaas de Greef, Huibert D. Mansvelder, Mahesh Miikael Karnani   +3 more
wiley   +1 more source

Early atrophy of pallidum and accumbens nucleus in Huntington's disease

, 2010
In Huntington's disease (HD) atrophy of the caudate nucleus and putamen has been described many years before clinical manifestation. Volume changes of the pallidum, thalamus, brainstem, accumbens nucleus, hippocampus, and amygdala are less well ...
Tabrizi, S.J., TRACK-HD Investigator Grp, Langbehn, D.R., Dumas, E.M., Buchem, M.A. van, Grond, J. van der, Johnson, H., Acharya, T.P., Scahill, R.I., Roos, R.A.C., Bogaard, S.J.A. van den   +10 more
core   +1 more source

Psychotropic medication and the fetal brain

The Journal of Physiology, EarlyView.
Abstract figure legend Brain region changes linked to in‐utero psychotropic exposure. Abstract Medications known to cross the blood–brain barrier (psychotropic medications) are commonly prescribed to women during pregnancy, often for the management of mental illness.
Oliver Gale‐Grant, Tomoki Arichi
wiley   +1 more source

Linking actions to outcomes : the role of the posterior pedunculopontine tegmental nucleus in instrumental learning

, 2012
Located in the mesopontine tegmentum, the pedunculopontine tegmental nucleus (PPTg) is comprised principally of glutamatergic, cholinergic and GABAergic neurons.
MacLaren, Duncan A. A.
core  

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]‐SMBT‐1 Positron‐Emission Tomography

Glia, Volume 74, Issue 8, August 2026.
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Lewis S. Crawford, James W. M. Kang, OIivia I. Davanzo, Hyunsol Lim, Sabrina Salberg, Marissa Srgo, Crystal Li, Gaelle M. Emvalomenos, Bianca Jupp, Matthew Long, Wayne Noonan, Mohammad B. Haskali, Richelle Mychasiuk, Kevin A. Keay, Luke A. Henderson   +14 more
wiley   +1 more source

Activational Effects of Gonadal Hormones on Social Reward Motivation in Adolescence and Adulthood in Female and Male Long–Evans Rats

Developmental Psychobiology, Volume 68, Issue 4, July 2026.
ABSTRACT There are age and sex differences in the processing of social reward, although the basis for these differences is not well established. We previously found greater social motivation at P50 (postpubertal adolescence) than at P70 (adulthood), and that female rats showed greater social motivation than male rats.
S. H. Murray, A. M. Randell, F. S. E. Krajcovic, B. C. J. Fletcher, C. M. McCormick   +4 more
wiley   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source

Modeling Deep Brain Stimulation in the Nucleus Accumbens as a Potential Treatment for Addiction [PDF]

, 2014
The nucleus accumbens is an important nucleus in the brain for reward and conditioning. In addiction, however, the nucleus accumbens is coopted to reinforce addictive behavior, creating a destructive influence in many lives.
Faber, Nathaniel
core  

The Orexin System Modulates Stress‐Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence

Addiction Biology, Volume 31, Issue 7, July 2026.
Chronic foot stress increases the vulnerability of adolescent mice to alcohol addiction‐related behaviours. Acute foot stress promotes the recovery of alcohol‐seeking behaviour in adolescent mice and increases orexin concentrations in the hippocampus, nucleus accumbens and prefrontal cortex.
Wenhao He, Aqian Hu, Tianshu Zhao, Li Deng, Huilin Wu, Xiaojun Xiang   +5 more
wiley   +1 more source

The Effect of Dopaminergic Medication on Impulse Control and Compulsive Behaviour: A Translational Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Dopaminergic medication used in disorders like Parkinson's disease (PD) and restless legs syndrome can cause impulsive‐compulsive behaviour (ICB), often with strong negative effects on patients' quality of life. This narrative review presents translational evidence on iatrogenic ICB, taking findings from epidemiological, clinical, neuroimaging
Mirjam Wolfschlag, Elena Espa, Kevin Oliveira Hauer, Jonathan Timpka, Ruben Smith, Per Odin, Maria Angela Cenci, Anders Håkansson   +7 more
wiley   +1 more source