Results 141 to 150 of about 376,324 (266)

Whole‐Brain Monosynaptic Inputs and Outputs of Corticotropin‐Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Using rabies‐based monosynaptic retrograde tracing and AAV anterograde labeling, this study maps the brain‐wide inputs and outputs of PVN CRH neurons, identifying them as a key hub coordinating stress, autonomic, and behavioral responses. ABSTRACT Objective The paraventricular nucleus of the hypothalamus (PVN) is a central hub integrating ...
Ziteng Yue, Danyang Zhao, Xinxin Chen, Yousheng Zhang, Heng Zhang, Yinchang Wang, Yuhang Liu, Yuxin Yang, Can Geng, Yimeng Song, Xiaoyi Wang, Sheng Wang   +11 more
wiley   +1 more source

Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The cycle between nicotine use and pain modulation. Cigarette smoking leads to nicotine entering the body, which binds to nicotinic acetylcholine receptors (nAChRs) in the brain, triggering the release of different neurotransmitters, including dopamine (DA), norepinephrine (NE), serotonin (5‐HT), and GABA.
Shan‐shan Hu, Chao‐feng Zhang, Battuvshin Lkhagvasuren, Di Wang   +3 more
wiley   +1 more source

Combination Pharmacotherapies for Obesity—Current Evidence and Future Directions

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Combination pharmacotherapy for obesity can enhance weight loss by targeting complementary neuroendocrine and metabolic pathways. Such benefits are largely additive but limited by tolerability, cost and access. This review outlines practical clinical archetypes and a research agenda for safer, more precise and durable combination strategies across ...
A. B. M. Kamrul‐Hasan, Arnav Kalra, Nitin Kapoor, Deep Dutta, Kunal Mahajan, Robin Maskey, Syed Abbas Raza   +6 more
wiley   +1 more source

Immediate early gene expression in the mesopontine tegmentum and midbrain after acute or chronic nicotine administration [PDF]

, 2008
The reinforcing properties of nicotine depend partly on cholinergic projections from the pedunculopontine tegmental (PPTg) and laterodorsal tegmental (LDTg) nuclei to midbrain dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars
Porter, Ailsa
core  

Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network

European Eating Disorders Review, Volume 34, Issue 5, Page 1314-1326, September 2026.
ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine, Melissa N. Veendijk, Jessie Nijman, Mieneke C. M. Luijendijk, Inge G. Wolterink‐Donselaar, Frank J. Meye, Roger A. H. Adan   +6 more
wiley   +1 more source

The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Hippocampal abnormalities are frequently associated with neurodevelopmental disorders as interneurons are crucial in establishing the network connectivity of neurons. This systematic review analyzed primary literature with a focus on aberrant hippocampal interneuron migration as an etiology for neurodevelopmental disorders, summarizing the ...
M. A. C. Till, H. M. O. Reid, I. Murphy, B. R. Christie   +3 more
wiley   +1 more source

The Human Subiculum and Its Role in Spatiotemporal Memory and Mental Imagery

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Traditionally viewed as a mere relay station of the hippocampal formation, the subiculum is emerging as a computational hub of the medial temporal lobe, essential for multiplexed neural representations guiding behavior. While foundational animal research has revealed that its sophisticated cytoarchitecture allows for conjunctive coding of ...
Hye Ja Kang, Maria Jieun Hwang, Ji Sun Kim, Ji Yeon Kim, Marie‐Agathe Crampon de Place, Sang Ah Lee   +5 more
wiley   +1 more source

Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 5, September 2026.
ABSTRACT Objective This review critically examines psilocybin, with particular emphasis on its pharmacokinetics and pharmacodynamics, including its serotonergic, neuroplastic, and anti‐inflammatory mechanisms. It integrates historical context, preclinical and clinical evidence, and evaluates emerging therapeutic potential, safety, microdosing practices,
José Norberto Vásquez‐Bonilla
wiley   +1 more source

The Evolution of Medications for Obesity Management

JGH Open, Volume 10, Issue 9, September 2026.
ABSTRACT This narrative review provides an overview of progress in the development of obesity medications, including a synthesis of data describing the efficacy and safety of currently available agents and emerging therapeutic options. Historically, many obesity medications have been withdrawn from the market due to safety concerns.
Jaskirath Gill, Priya Sumithran
wiley   +1 more source

Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats

, 2012
Dysfunctional reconsolidation processes may help drug memories resist extinction and contribute to high rate of relapse. Reconsolidation of drug memory is mainly affected by the appetitive and aversive emotional experiences associated with an addictive ...
Sui, Nan, Wu, Yan, Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China., Li, Yonghui, Gao, Jun   +4 more
core   +1 more source