Results 131 to 140 of about 376,324 (266)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, Volume 13, Issue 49, 3 September 2026.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Abstinence from cocaine self-administration promotes microglial pruning of astrocytes, which drives cocaine-seeking behavior

Cell Reports
Summary: Rodent drug self-administration leads to a compromised ability of nucleus accumbens astrocytes to maintain glutamate homeostasis as well as to reductions in surface area, volume, and synaptic colocalization of astrocyte membranes.
Anze Testen, Jonathan W. VanRyzin, Tania J. Bellinger, Ronald Kim, Han Wang, Matthew J. Gastinger, Emily A. Witt, Janay P. Franklin, Haley A. Vecchiarelli, Katherine Picard, Michael D. Scofield, Marie-Ève Tremblay, Kathryn J. Reissner   +12 more
doaj   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear. METHODS By integrating genome‐wide association datasets for three DTI‐ALPS traits and seven NDDs, we quantified polygenic overlap using MiXeR ...
Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He, Feng Liu   +10 more
wiley   +1 more source

Spatial memory, plasticity and nucleus accumbens

, 2012
Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction.
Alberto Oliverio, RINALDI, ARIANNA, MELE, Andrea   +2 more
core   +1 more source

Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objective This review systematically elaborates multi‐system interactive mechanisms underlying comorbid chronic low back pain (CLBP) and major depressive disorder (MDD), synthesizes recent advances in diagnosis, treatment, and management, and proposes precision medicine directions to address clinical challenges, including missed diagnosis ...
Lin Faqu, Lin Chenjuan, Xiang Xiangyin, Li Xin   +3 more
wiley   +1 more source

The Neuroscience of Religious and Spiritual Practices: A Systematic Review of Neurotheological Evidence

Brain and Behavior, Volume 16, Issue 9, September 2026.
Systematic synthesis of 105 neuroimaging and neurophysiological studies demonstrates that religious and spiritual practices, including meditation, prayer, chanting, worship, and mystical experiences, produce practice‐specific neuroplastic changes in brain networks governing attention, self‐referential processing, emotion regulation, connectivity ...
Waqar Husain, Achraf Ammar, Urwa‐Tul Wusqa, Maha Farooq, Zehra Tariq, Seithikurippu R. Pandi‐Perumal, Ahmed S. BaHammam, Khaled Trabelsi, Mark D. Griffiths, Amir Pakpour, Haitham Jahrami   +10 more
wiley   +1 more source

Music and Exercise in Concert: Uncovering Synergistic Mechanisms for Enhancing Brain Health and Cognitive Resilience—A Narrative Review

Brain and Behavior, Volume 16, Issue 9, September 2026.
Music and physical exercise share convergent neurobiological mechanisms, including neuroplasticity, metabolic regulation, and neuroinflammatory modulation. Integrating music with exercise produces synergistic effects that enhance brain function beyond single interventions.
Sanxia Yang, Qingluan Liu, Minghui Wang, Yidan Zhang   +3 more
wiley   +1 more source

Zur Entstehung einer Imbalance im limbo-präfrontalen System bei Meriones unguiculatus : der Einfluss restriktiver Isolationsaufzucht und einer postnatalen Methamphetamin-Intoxikation auf die monoaminergen Transmitter Dopamin und Serotonin [PDF]

, 2004
Busche A. Zur Entstehung einer Imbalance im limbo-präfrontalen System bei Meriones unguiculatus : der Einfluss restriktiver Isolationsaufzucht und einer postnatalen Methamphetamin-Intoxikation auf die monoaminergen Transmitter Dopamin und Serotonin ...
Busche, Andrea
core  

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate

Chirality, Volume 38, Issue 9, September 2026.
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo, Renato Lúcio de Carvalho, Juliana Almeida Sad, Pedro Henrique Costa dos Santos, Rhaiza Silva Domingues, Gabriele de Azevedo Cardoso, Karine Braga Enes, Gisele Assis Castro Goulart, Maila de Castro Lourenço das Neves, Ângelo de Fátima   +9 more
wiley   +1 more source