Results 181 to 190 of about 525,575 (332)

Behavioral profile predicts ethanol preference in adolescent mice, but not in adults: A machine learning approach

Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
The present study reveals that adolescent behavioral phenotypes strongly predict ethanol preference in mice, while no predictive patterns emerged in adulthood. Machine learning analysis identified sucrose preference as a positive predictor and sociability as a negative predictor of alcohol intake, highlighting natural reward sensitivity and social ...
Liana C. L. Portugal, Bruno da Silva Gonçalves, Emily de Assis Fagundes, Maria Fernandes Freire de Sá, Cláudio Carneiro Filgueiras, Ana Carolina Dutra‐Tavares, Alex C. Manhães, Yael Abreu‐Villaça, Anderson Ribeiro‐Carvalho   +8 more
wiley   +1 more source

A thalamic input to the nucleus accumbens mediates opiate dependence

Nature, 2016
Yingjie Zhu, Carl F. R. Wienecke, G. Nachtrab, Xiaoke Chen   +3 more
semanticscholar   +1 more source

Effects of cannabidiol in alcohol use disorder patients with and without co‐occurring post‐traumatic stress disorder: Tolerability but no evidence for efficacy in two randomized proof‐of‐concept trials

Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
Two small placebo‐controlled trials evaluated the effects of cannabidiol (CBD) in patients with alcohol use disorder (AUD), with and without co‐occurring post‐traumatic stress disorder (PTSD). CBD was rapidly absorbed and generally well tolerated in dosages of up to 1200 mg/day. Both treatment groups showed large reductions in drinking.
Michael P. Bogenschutz, Esther Blessing, Danielle Dgheim, Dayeon Cho, Jun Zhang, Eugene M. Laska, Charles R. Marmar   +6 more
wiley   +1 more source

DUSP5 Downregulation in Nucleus Accumbens Core Correlates with Cocaine-Induced Maladaptive Synaptic Plasticity. [PDF]

Cells
Taborda-Bejarano JP, Meyerink M, Crans DC, Ramchandran R, Garcia-Keller C.   +4 more
europepmc   +1 more source

Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression

Biological Psychiatry, 2017
T. C. Francis, M. Lobo
semanticscholar   +1 more source

Pain-Related Nucleus Accumbens Function

, 2019
The nucleus accumbens (NAc) has been implicated in sleep, reward, and pain modulation, but the relationship between these functional roles is unclear. This study aimed to determine whether NAc function at the onset and offset of a noxious thermal stimulus is enhanced by rewarding music, and whether that effect is reversed by experimental sleep ...
Seminowicz, David A, Remeniuk, Bethany, Krimmel, Samuel R, Smith, Michael T, Barrett, Frederick S, Wulff, Andreas B, Furman, Andrew J, Geuter, Stephan, Lindquist, Martin A, Irwin, Michael R, Finan, Patrick H   +10 more
openaire   +2 more sources

Alcohol and the endocrine system: A critical review of disruptions, potential mechanisms, and health implications

Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley   +1 more source

Deficiency of Shank3 in the nucleus accumbens reveals a loss of social-specific motivation. [PDF]

Commun Biol
Folkes OM, Donahue M, Wang SE, Negrón-Moreno PN, Oo NX, Qiao SN, Wang X, Jiang YH.   +7 more
europepmc   +1 more source

Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice

, 2011
Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima, Kohei Shimada, Koichi Ishiguro, Hiroshi Mizuma, Hirotaka Onoe, Yoshikuni Mizuno, Nobutaka Hattori   +15 more
openalex   +2 more sources

Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose ‘Liking’ and Intake but Scopolamine in Caudal Shell Shifts ‘Liking’ Toward ‘Disgust’ and ‘Fear’ [PDF]

, 2016
Daniel C. Castro, Rachel A Terry, Kent Berridge   +2 more
openalex   +1 more source