Results 61 to 70 of about 72,699 (283)

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood

Neurobiology of Sleep and Circadian Rhythms
Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes.
Alexis N. Jameson, Justin K. Siemann, Carrie A. Grueter, BradA. Grueter, Douglas G. McMahon   +4 more
doaj   +1 more source

mGluR5 stimulates gliotransmission in the nucleus accumbens [PDF]

Proceedings of the National Academy of Sciences, 2007
Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the cellular actions of this receptor in the nucleus accumbens (NAc). Although mGluR5 has the potential to regulate neurons directly, recent studies have shown the importance of mGluR5 in
D'Ascenzo, Marcello, Fellin, Tommaso, Terunuma, Miho, Revilla Sanchez, Raquel, Meaney, David F., Auberson, Yves P., Moss, Stephen J., Haydon, Philip G.   +7 more
openaire   +3 more sources

Dynamic risk control by human nucleus accumbens [PDF]

, 2015
Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed
Strange, BA, Lopez-Sosa, Fernando, López Sosa, Fernando, Avecillas, J, Barcia, Juan Antonio, Reneses, B, Pineda-Pardo, Jose Angel, Gonzalez-Rosa, Javier Jesus, Strange, B, Gonzalez-Rosa, JJ, Barcia, JA, Barcia, Juan A., Reneses, Blanca, Strange, Bryan, Pineda-Pardo, JA, Galarza, Ana, Nachev, P, González Rosa, Javier Jesús, Lopez-Ibor, JJ, Lopez-Ibor, Juan José, Lopez-Sosa, F, Lopez-Ibor, JA, Galarza, A, Avecillas, Josue, Nachev, Parashkev   +24 more
core   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Is Deep Brain Stimulation a viable treatment for substance-related addiction? [PDF]

Romanian Journal of Neurology, 2019
For the ability to modulate the activity of dysregulated networks Deep Brain Stimulation (DBS) of areas involved in reward system and motivational states may have a potential application in addiction despite risks associated with its invasiveness.
Giusy Guzzi, Angelo Lavano, Serena Marianna Lavano, Rosa Marotta   +3 more
doaj   +1 more source

Effort discounting in human nucleus accumbens [PDF]

Cognitive, Affective, & Behavioral Neuroscience, 2009
A great deal of behavioral and economic research suggests that the value attached to a reward stands in inverse relation to the amount of effort required to obtain it, a principle known as effort discounting. In the present article, we present the first direct evidence for a neural analogue of effort discounting.
Matthew M, Botvinick, Stacy, Huffstetler, Joseph T, McGuire   +2 more
openaire   +2 more sources

Efeitos das injeções de agonistas e antagonistas gabaérgicos e agonistas serotonérgicos na concha do núcleo accumbens sobre comportamentos defensivos e ingestivos em ratos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasA fim de estabelecer uma relacao funcional entre o controle dos comportamentos defensivos e ingestivos em ratos, esse ...
Lopes, Ana Paula Fraga
core  

Neuropsychology of reinforcement processes in the rat

, 2011
This thesis investigated the role played by regions of the prefrontal cortex and ventral striatum in the control of rats’ behaviour by Pavlovian conditioned stimuli, and in their capacity to choose delayed reinforcement.

core   +1 more source