Gut microbiota as a novel therapeutic target for eating disorders and obesity
British Journal of Pharmacology, EarlyView.The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė +5 more
wiley +1 more source
Nucleus accumbens activation mediates the influence of reward cues on financial risk-taking [PDF]
In functional magnetic resonance imaging (FMRI) research, nucleus accumbens (NAcc) activation spontaneously increases prior to financial risk taking.
Winkielman, Piotr +3 more
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Efeito da microinjeção de antagonista dos receptores glutamatérgicos do tipo AMPA no centro e na concha do Núcleo Accumbens sobre a emocionalidade e ingestão de alimento, em ratos Wistar fêmeas [PDF]
, 2008 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.O presente estudo teve como objetivo avaliar o efeito da microinjeção de antagonista dos receptores AMPA (a-amino-3 ...
Cunha, Isabel Cristina da
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Dynamic risk control by human nucleus accumbens [PDF]
, 2015 Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed
Strange, BA +24 more
core +1 more source
Multimodal characterization of the human nucleus accumbens
NeuroImage, 2019 Dysregulation of the nucleus accumbens (NAc) is implicated in numerous neuropsychiatric disorders. Treatments targeting this area directly (e.g. deep brain stimulation) demonstrate variable efficacy, perhaps owing to non-specific targeting of a functionally heterogeneous nucleus.
Samuel CD. Cartmell +11 more
openaire +3 more sources
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Adaptive Reifung von Dopamin und Serotonin im Nucleus accumbens, der integrativen Schnittebene zwischen Emotion und Bewegung : Isolationsaufzucht und Methamphetamin-Intoxikation als Induktoren einer gestörten Reifung bei Meriones unguiculatus [PDF]
, 2005 Lesting J. Adaptive Reifung von Dopamin und Serotonin im Nucleus accumbens, der integrativen Schnittebene zwischen Emotion und Bewegung : Isolationsaufzucht und Methamphetamin-Intoxikation als Induktoren einer gestörten Reifung bei Meriones unguiculatus.
Lesting, Jörg
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Amygdala-nucleus accumbens associations.
, 2018 Amygdala-nucleus accumbens associations.
Elaine Y. Hsiao (5598281) +6 more
core +1 more source
Dopamine, behavioral economics, and effort
Frontiers in Behavioral Neuroscience, 2009 . There are numerous problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food.
John D Salamone +4 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli +6 more
wiley +1 more source