Results 101 to 110 of about 376,324 (266)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

How does the nucleus accumbens tick? [PDF]

, 2000
El nucleus accumbens se considera una interfase neural entre motivación y acción motora, y participa de modo decisivo en la ingesta, conducta sexual, recompensa, respuesta al estrés, autoadminstración de drogas, etc. Desarrollo.
Fernández-Espejo, Emilio
core   +1 more source

Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia

Translational Psychiatry
Quantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues’ magnetic susceptibility, including iron deposition and myelination.
Shuhei Shibukawa, Hirohito Kan, Shiori Honda, Masataka Wada, Ryosuke Tarumi, Sakiko Tsugawa, Yui Tobari, Norihide Maikusa, Masaru Mimura, Hiroyuki Uchida, Yuko Nakamura, Shinichiro Nakajima, Yoshihiro Noda, Shinsuke Koike   +13 more
doaj   +1 more source

Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to atrazine

Frontiers in Toxicology
The herbicide atrazine (ATR) has been one of the most widely used herbicides worldwide. However, due to its indiscriminate use, it has been considered an environmental contaminant. Several studies have classified ATR as an endocrine disruptor, and it has
Triana Acevedo-Huergo, Jonathan Sánchez-Yépez, María Soledad Mendoza-Trejo, Isela Hernández-Plata, Magda Giordano, Verónica Mireya Rodríguez   +5 more
doaj   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Longitudinal MRI studies of children with attention‐deficit/hyperactivity disorder: A systematic review

Psychiatry and Clinical Neurosciences, EarlyView.
We reviewed longitudinal magnetic resonance imaging (MRI) studies exploring the brain development of children with attention‐deficit/hyperactivity disorder (ADHD). Specifically, we conducted a systematic review of papers published until 9 September 2025 in English on pediatric patients with ADHD.
Ayaka Ishii‐Takahashi, Yuzu Yoshimaru, Dwi Muhammad, Takuya Kawahara, Rio Yamaguchi   +4 more
wiley   +1 more source

Corticostriatal plasticity in the nucleus accumbens core

Journal of Neuroscience Research, 2019
AbstractSmall fluctuations in striatal glutamate and dopamine are required to establish goal‐directed behaviors and motor learning, while large changes appear to underlie many neuropsychological disorders, including drug dependence and Parkinson's disease.
Nigel S. Bamford, Wengang Wang
openaire   +3 more sources

Nature, nurture, and 5‐HT4R: Familial predisposition, not parental bonding, is associated with brain 5‐HT4R in a sex‐specific manner

Psychiatry and Clinical Neurosciences, EarlyView.
Background Major depressive disorder (MDD) aggregates in families. The neostriatum, key to reward and attachment circuits, has the highest density of serotonin 4 receptors (5‐HT4R). Striatal 5‐HT4R is low in MDD and linked to familial depression risk. Poor parental bonding increases depression risk, yet whether nature and nurture converge on 5‐HT4R is ...
Randi T. Kjær, Martin B. Jørgensen, Kristian H. R. Jensen   +2 more
wiley   +1 more source

Reliability of Glutamate Quantification in Human Nucleus Accumbens Using Proton Magnetic Resonance Spectroscopy at a 70-cm Wide-Bore Clinical 3T MRI System

Frontiers in Neuroscience, 2017
The human nucleus accumbens is a challenging region to study using proton magnetic resonance spectroscopy (1H-MRS) on a 70-cm wide-bore clinical 3T MRI system.
Xi-Long Liu, Long Li, Jian-Neng Li, Jia-Hui Rong, Bo Liu, Ze-Xuan Hu   +5 more
doaj   +1 more source

Parkinson's disease under dopamine replacement therapy as a human framework for studying addiction‐relevant mechanisms

Psychiatry and Clinical Neurosciences, EarlyView.
Addiction is a chronic relapsing condition characterized by compulsive reward seeking and impaired behavioral control, associated with major individual and societal burden. Mechanistic investigation in humans remains constrained by ethical limitations, uncontrolled exposure histories, and ecological confounds.
Vanessa Fleury, Elvira Pirondini, Damien Benis, Tiffany Corbet, Gabriel Thorens, Christian Lüscher, Paul Krack   +6 more
wiley   +1 more source