Results 71 to 80 of about 72,699 (283)

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Nucleus accumbens deep brain stimulation in adult patients suffering from severe and enduring anorexia nervosa (STIMARS): protocol for a pilot study

Frontiers in Psychiatry
BackgroundAffecting adolescent and young adults, anorexia nervosa (AN) has the highest death rate of all mental disorders. Effective treatment options are lacking and a significant proportion of patients develop severe and chronic forms of the disease ...
Philibert Duriez, Philibert Duriez, Giorgia Antonia Simboli, Giorgia Antonia Simboli, Philippe Domenech, Philippe Domenech, Philippe Domenech, Anne Buot, Anne Buot, Casey Halpern, Casey Halpern, Marie Fadigas, Yann Mongin, Aurore Guy-Rubin, Romain Carron, Romain Carron, Catherine Oppenheim, Catherine Oppenheim, Philip Gorwood, Philip Gorwood, Johan Pallud, Johan Pallud, Marc Zanello, Marc Zanello   +23 more
doaj   +1 more source

Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice

BMC Neuroscience, 2007
Background Calcium/calmodulin-dependent protein kinase IV (CaMKIV) controls activity-dependent gene transcription by regulating the activity of the cyclic AMP response element binding protein (CREB). This signaling pathway is involved in gating emotional
Bading Hilmar, Zhang Sheng-Jia, Spanagel Rainer, Schneider Miriam, Klugmann Matthias   +4 more
doaj   +1 more source

Efeito da microinjeção de antagonista dos receptores glutamatérgicos do tipo AMPA no centro e na concha do Núcleo Accumbens sobre a emocionalidade e ingestão de alimento, em ratos Wistar fêmeas [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.O presente estudo teve como objetivo avaliar o efeito da microinjeção de antagonista dos receptores AMPA (a-amino-3 ...
Cunha, Isabel Cristina da
core  

“Hands‐On” white matter anatomy: Using Air Anatomy gestures and tractography on simple brain sections to enhance teaching of white matter directions

Anatomical Sciences Education, EarlyView.
Abstract Teaching white matter (WM) anatomy to undergraduates is challenging. This is partly because WM fibers are oriented intricately and Klingler's dissection, the gold standard method used to demonstrate it, often requires time, advanced anatomical knowledge, and refined dissection skills.
Doris George Yohannan, Rohini Punja, Thomas Iype, Chandrasekharan Kesavadas, Bejoy Thomas, Kannanvilakom Govindapillai Umesan, Aswathy Maria Oommen, Usha Devi Keezhathil Bhargavi   +7 more
wiley   +1 more source

Amygdala-nucleus accumbens associations.

, 2018
Amygdala-nucleus accumbens associations.
Elaine Y. Hsiao (5598281), Emeran A. Mayer (391674), Cody Ashe-McNalley (454690), Vadim Osadchiy (1704199), Jonathan Jacobs (5598278), Arpana Gupta (454689), Jennifer S. Labus (507297)   +6 more
core   +1 more source

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice

Autism Research, EarlyView.
ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown.
Krisztina Sáfár, Vivien Szendi, Paulina Hoppa, Yutong Wang, Fanni Á. Seres, Szilvia Bartók, Tyler Teadora, Lei Shi, Árpád Dobolyi, Gina Puska, István Adorján   +10 more
wiley   +1 more source

Homeostatic-related peptides injected into the rat nucleus accumbens alter palatable eating and impact the binge-like intake of a sweetened fat diet during simultaneous μ-opioid receptor stimulation

Frontiers in Neuroscience
BackgroundThe nucleus accumbens is central for directing motivated behavior and is a key node in the neural circuitry that promotes eating in response to palatable diets.
Wayne E. Pratt, Cardinal Do, Alexandra M. Groome, Alana J. Smith, Allison C. Siegfried, Camryn J. Calafiore   +5 more
doaj   +1 more source

Linking Brain Morphometry to Psychometric Measures and Energy‐Metabolic Biomarkers in Adults With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is associated with differences in neurodevelopment and altered metabolism, yet the interplay between brain morphometry, mitochondrial and energy metabolism biomarkers, and autistic traits in adults remains poorly understood. This study investigates the link between brain structure, psychometric measures, and both
Eleonora Esposto, Kathrin Nickel, Dominique Endres, Kimon Runge, Katharina Domschke, Thomas Lange, Marco Reisert, Anke Schumann, Cinzia Niolu, Ludger Tebartz van Elst, Simon Maier   +10 more
wiley   +1 more source

Dynamic gating in the nucleus accumbens: Behavioral state-dependent synchrony with the prefrontal cortex and hippocampus

, 2008
Contextual and sensory information, goals, and the motor plan to achieve them are integrated in the nucleus accumbens (NA). Although this integration needs flexibility to operate in a variety of environments, models of NA function rarely consider ...
Rifat J. Hussain, Patricio O'Donnell, Aaron J. Gruber   +2 more
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