Results 1 to 10 of about 473,018 (289)

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Molecular Medicine, 2021
Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis).
Liang Shan, Ximing Xu, Jing Zhang, Peng Cai, Han Gao, Yingjie Lu, Jiangang Shi, Yinlong Guo, Yue Su   +8 more
doaj   +2 more sources

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

Journal of Orthopaedic Surgery and Research, 2021
Background To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment. Methods The gene expression data was downloaded from the NCBI Gene Expression Omnibus (GEO) database ( https ...
Cun Zhang, Tong Tong, De-chao Miao, Lin-feng Wang   +3 more
doaj   +2 more sources

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

BMC Medical Genomics, 2021
Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis.
Chen Xu, Shengchang Luo, Leixin Wei, Huiqiao Wu, Wei Gu, Wenchao Zhou, Baifeng Sun, Bo Hu, Hongyu Zhou, Yang Liu, Huajiang Chen, Xiaojian Ye, Wen Yuan   +12 more
doaj   +2 more sources

Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells [PDF]

Open Life Sciences
Abstract Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs.
Meng Yingying, Liu Wei, Liu Haifeng, Yu Chengwei   +3 more
doaj   +4 more sources

Cell sources proposed for nucleus pulposus regeneration [PDF]

JOR SPINE, 2021
Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD).
Rebecca Williams, M. Tryfonidou, J. Snuggs, C. L. Le Maitre   +3 more
semanticscholar   +8 more sources

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +2 more sources

Protein in the Nucleus Pulposus of the Intervertebral Disk [PDF]

Nature, 1962
THE nucleus pulposus of the normal human intervertebral disk consists of collagen fibrils dispersed in a gel of polysaccharide and protein complexes. During ageing collagen fibrils are deposited as a matrix showing increasing orientation with age as seen from X-ray diffraction investigations1.
P. R. Blakey, F. Happey, A. Naylor, Robert L. Turner   +3 more
openalex   +4 more sources

The Proteinpolysaccharides of Bovine Nucleus Pulposus

Journal of Biological Chemistry, 1967
Abstract Bovine nucleus pulposus has been found to be a good source of a series of proteinpolysaccharides containing chondroitin 6-sulfate and keratan sulfate. Six distinct fractions have been separated, totaling 40% of the dry weight of the tissue. Each fraction contains protein, chondroitin 6-sulfate, and keratan sulfate, but the proportions of these
Lawrence Rosenberg, Maxwell Schubert, John Sandson   +2 more
openalex   +3 more sources

The Mucopolysaccharides of Nucleus Pulposus. [PDF]

Acta Chemica Scandinavica, 1955
S. Gardell, Lennart Rodén, A. Vestermark, Albertina Caglieris   +3 more
openalex   +4 more sources

On the Biology of Nucleus Pulposus [PDF]

Acta Orthopaedica Scandinavica, 1951
Bengt Sylvén
openalex   +4 more sources