Results 1 to 10 of about 494,442 (303)

Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells [PDF]

Open Life Sciences
Abstract Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs.
Meng Yingying, Liu Wei, Liu Haifeng, Yu Chengwei   +3 more
doaj   +4 more sources

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Molecular Medicine, 2021
Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis).
Liang Shan, Ximing Xu, Jing Zhang, Peng Cai, Han Gao, Yingjie Lu, Jiangang Shi, Yinlong Guo, Yue Su   +8 more
doaj   +2 more sources

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

Journal of Orthopaedic Surgery and Research, 2021
Background To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment. Methods The gene expression data was downloaded from the NCBI Gene Expression Omnibus (GEO) database ( https ...
Cun Zhang, Tong Tong, De-chao Miao, Lin-feng Wang   +3 more
doaj   +2 more sources

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

BMC Medical Genomics, 2021
Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis.
Chen Xu, Shengchang Luo, Leixin Wei, Huiqiao Wu, Wei Gu, Wenchao Zhou, Baifeng Sun, Bo Hu, Hongyu Zhou, Yang Liu, Huajiang Chen, Xiaojian Ye, Wen Yuan   +12 more
doaj   +2 more sources

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +2 more sources

Cell sources proposed for nucleus pulposus regeneration [PDF]

JOR SPINE, 2021
AbstractLower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD). The current treatments for chronic back pain only provide alleviation of symptoms through pain relief, tissue removal, or ...
Williams, Rebecca J., Tryfonidou, Marianna A., Snuggs, Joseph Wiliam, Le Maitre, Christine Lyn   +3 more
openaire   +9 more sources

Knockdown of miR-660 protects nucleus pulposus cells from TNF-a-induced apoptosis by targeting serum amyloid A1

Journal of Orthopaedic Surgery and Research, 2020
Background Intervertebral disc degeneration (IVDD) is a well-known cause of lower back pain, which is induced by multiple factors including increased apoptosis and decreased survival of nucleus pulposus cells.
Hao Jie Zhang, Xue Hai Ma, Song Lin Xie, Shu lian Qin, Cong Zhi Liu, Zhen Guo Zhang   +5 more
doaj   +2 more sources

Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration

Cell Cycle, 2023
Intervertebral disc degeneration (IVDD), a widely known contributor to low back pain (LBP), has been proved to be a global health challenging conundrum. Hesperidin (hesperetin-7-O-rutinoside, HRD) is a flavanone glycoside that belongs to the subgroup of ...
Jian Zhu, Ruping Sun, Chen Yan, Kaiqiang Sun, Lu Gao, B. Zheng, Jian-gang Shi   +6 more
semanticscholar   +1 more source

Immune exposure: how macrophages interact with the nucleus pulposus

Frontiers in Immunology, 2023
Intervertebral disc degeneration (IDD) is a primary contributor to low back pain. Immune cells play an extremely important role in modulating the progression of IDD by interacting with disc nucleus pulposus (NP) cells and extracellular matrix (ECM ...
Peng Feng, Ying Che, Chunyu Gao, Liguo Zhu, Jinghua Gao, N. Vo   +5 more
semanticscholar   +1 more source

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Experimental and Molecular Medicine, 2022
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of
Weifeng Zhang, Gaocai Li, Rongjin Luo, J. Lei, Yu Song, Bingjin Wang, Liang Ma, Zhiwei Liao, Wencan Ke, Hui Liu, Wenbin Hua, K. Zhao, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Kun Wang, Cao Yang   +16 more
semanticscholar   +1 more source