Results 1 to 10 of about 483,128 (333)

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Molecular Medicine, 2021
Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis).
Liang Shan, Ximing Xu, Jing Zhang, Peng Cai, Han Gao, Yingjie Lu, Jiangang Shi, Yinlong Guo, Yue Su   +8 more
doaj   +2 more sources

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

Journal of Orthopaedic Surgery and Research, 2021
Background To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment. Methods The gene expression data was downloaded from the NCBI Gene Expression Omnibus (GEO) database ( https ...
Cun Zhang, Tong Tong, De-chao Miao, Lin-feng Wang   +3 more
doaj   +2 more sources

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

BMC Medical Genomics, 2021
Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis.
Chen Xu, Shengchang Luo, Leixin Wei, Huiqiao Wu, Wei Gu, Wenchao Zhou, Baifeng Sun, Bo Hu, Hongyu Zhou, Yang Liu, Huajiang Chen, Xiaojian Ye, Wen Yuan   +12 more
doaj   +2 more sources

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +2 more sources

Co-culture of Adult Mesenchymal Stem Cells and Nucleus Pulposus Cells in Bilaminar Pellets for Intervertebral Disc Regeneration [PDF]

, 2009
Background: Our goal is to optimize stem cell-based tissue engineering strategies in the context of the intervertebral disc environment. We explored the benefits of co-culturing nucleus pulposus cells (NPC) and adult mesenchymal stem cells (MSC) using a ...
Allon, AA, Lotz, JC, Schneider, RA
core   +4 more sources

Dynamic behavior of the nucleus pulposus within the intervertebral disc loading: a systematic review and meta-analysis exploring the concept of dynamic disc model [PDF]

Frontiers in Bioengineering and Biotechnology
IntroductionThe dynamic disc model (DDM) is a theoretical framework in spine mechanics that theorizes the behavior of the nucleus pulposus within the intervertebral disc under various loads.
Jean-Philippe Deneuville, Jean-Philippe Deneuville, Jean-Philippe Deneuville, Maxime Billot, Alexandra Cervantes, Sylvain Peterlongo, Martin Meyer, Mezika Kolder, Marie Escande, Mathilde Bourgeois, Adrien Pallot, Adrien Pallot, Romain David, Romain David, Romain David, Manuel Roulaud, Amine Ounajim, Mark Laslett, Mathieu Sarracanie, Najat Salameh, Arnaud Germaneau, Philippe Rigoard, Philippe Rigoard, Philippe Rigoard   +23 more
doaj   +2 more sources

Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention

Molecular Medicine
Background Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the normal biological properties of disc ...
Tao Ma, Chen Liu, Quanlai Zhao, Yu Zhang, Liang Xiao   +4 more
doaj   +2 more sources

Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype [PDF]

Journal of Functional Biomaterials
The intervertebral disc, an anatomical compartment interposed between vertebral bodies, plays a key role in spine flexibility and compression loading.
Narjes Rashidi, Nicholas Dowell, Derek Covill, John Shepperd, Matteo Santin   +4 more
doaj   +2 more sources

MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21

Molecular Therapy: Nucleic Acids, 2021
Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted.
Yiqiang Sun, Xia Wang, Guoyong Fu, Xiaopeng Geng   +3 more
doaj   +1 more source

Immune exposure: how macrophages interact with the nucleus pulposus

Frontiers in Immunology, 2023
Intervertebral disc degeneration (IDD) is a primary contributor to low back pain. Immune cells play an extremely important role in modulating the progression of IDD by interacting with disc nucleus pulposus (NP) cells and extracellular matrix (ECM ...
Peng Feng, Ying Che, Chunyu Gao, Liguo Zhu, Jinghua Gao, N. Vo   +5 more
semanticscholar   +1 more source