Results 1 to 10 of about 18,919 (201)

Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment [PDF]

JOR Spine
Background Condoliase is a treatment for lumbar disc herniation. This enzyme exerts its medicinal effects by digesting chondroitin sulfate (CS), which is abundant in the nucleus pulposus.
Ippei Watanabe, Ko Takeda, Taiichi Shirogane   +2 more
doaj   +2 more sources

Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration [PDF]

JOR Spine
Background Condoliase is an enzyme used as a treatment for lumbar disc herniation (LDH). This enzyme degrades chondroitin sulfate (CS) in the nucleus pulposus of the intervertebral disc (IVD).
Yuka Minamisawa, Taiichi Shirogane, Ippei Watanabe, Akira Dezawa   +3 more
doaj   +2 more sources

Zmpste24 deficiency contributes to intervertebral disc degeneration by undermining the stability of the nuclear membrane of nucleus pulposus cells. [PDF]

PeerJ
Han C, Fu S, Wang H, Zhang K, Zhao J.
europepmc   +2 more sources

MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21

Molecular Therapy: Nucleic Acids, 2021
Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted.
Yiqiang Sun, Xia Wang, Guoyong Fu, Xiaopeng Geng   +3 more
doaj   +1 more source

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Molecular Medicine, 2021
Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis).
Liang Shan, Ximing Xu, Jing Zhang, Peng Cai, Han Gao, Yingjie Lu, Jiangang Shi, Yinlong Guo, Yue Su   +8 more
doaj   +1 more source

MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. [PDF]

PLoS ONE, 2013
Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis of intervertebral disc degeneration. Recent findings revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many pathological ...
Xin Yu, Zheng Li, Jianxiong Shen, William K K Wu, Jinqian Liang, Xisheng Weng, Guixing Qiu   +6 more
doaj   +1 more source

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

Journal of Orthopaedic Surgery and Research, 2021
Background To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment. Methods The gene expression data was downloaded from the NCBI Gene Expression Omnibus (GEO) database ( https ...
Cun Zhang, Tong Tong, De-chao Miao, Lin-feng Wang   +3 more
doaj   +1 more source

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

BMC Medical Genomics, 2021
Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis.
Chen Xu, Shengchang Luo, Leixin Wei, Huiqiao Wu, Wei Gu, Wenchao Zhou, Baifeng Sun, Bo Hu, Hongyu Zhou, Yang Liu, Huajiang Chen, Xiaojian Ye, Wen Yuan   +12 more
doaj   +1 more source

Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation

Frontiers in Pharmacology, 2022
Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation ...
Xiaochun Li, Xiaochun Li, Xueqiang Shen, Xueqiang Shen, Zhiqiang Wang, Zhiqiang Wang, Hong Jiang, Hong Jiang, Zhijia Ma, Zhijia Ma, Pengfei Yu, Pengfei Yu, Zhenhan Yu, Zhenhan Yu, Xiang Qian, Xiang Qian, Jintao Liu, Jintao Liu   +17 more
doaj   +1 more source

Non-Coding RNA Extraction from Nucleus Pulposus of Intervertebral Discs with Subsequent Expression Profiling

Креативная хирургия и онкология, 2020
Background. With numerous extraction protocols for total RNA and RNA fractions, like microRNA (miRNA) and long non-coding RNA (lncRNA), available for various cell and tissue types, obtaining a high quantitative and qualitative yield from some special ...
I. F. Gareev, O. A. Beylerli, G. Yang, D. Zhang   +3 more
doaj   +1 more source