Results 11 to 20 of about 348,318 (186)
A preliminary feasibility study of a tough hydrogel as a nucleus pulposus substitute for degenerative disc disease. [PDF]
Front Bioeng BiotechnolIntroductionDegenerative disc disease is characterized by low back pain caused by degeneration of the intervertebral discs. Hydrogels, with favorable biocompatibility and characteristics resembling the nucleus pulposus, have received attention as ...
Kang YM +7 more
europepmc +2 more sources
Non-Coding RNA Extraction from Nucleus Pulposus of Intervertebral Discs with Subsequent Expression Profiling [PDF]
Креативная хирургия и онкология, 2020 Background. With numerous extraction protocols for total RNA and RNA fractions, like microRNA (miRNA) and long non-coding RNA (lncRNA), available for various cell and tissue types, obtaining a high quantitative and qualitative yield from some special ...
I. F. Gareev +3 more
doaj +2 more sources
Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment. [PDF]
JOR SpineBackground Condoliase is a treatment for lumbar disc herniation. This enzyme exerts its medicinal effects by digesting chondroitin sulfate (CS), which is abundant in the nucleus pulposus.
Watanabe I, Takeda K, Shirogane T.
europepmc +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Nucleus pulposus cell (NPC) apoptosis is the main factor in intervertebral disc degeneration (IDD); thus, inhibiting the excessive apoptosis of nucleus pulposus cells may be a potential way to alleviate IDD. The effect of Hemeoxygenase-1
Chaoying Zhu +4 more
exaly +3 more sources
PHGDH-Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration. [PDF]
Adv Sci (Weinh)When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Xu HW +5 more
europepmc +2 more sources
Molecular Medicine, 2021 Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis).
Liang Shan +8 more
doaj +1 more source
The Poisson’s ratio of the nucleus pulposus is strain dependent [PDF]
, 2012 Part of the Soft Tissue Biomechanics Session this presentation is to characterise the true Poisson’s ratio of the nucleus pulposus is strain ...
Farrell, Mark, Riches, Philip
core +4 more sources
Molecular Therapy: Nucleic Acids, 2021 Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted.
Yiqiang Sun +3 more
doaj +1 more source
Poisson’s ratio of nucleus pulposus tissue : comparison of experimental results with a biphasic poroviscoelastic finite element model [PDF]
, 2012 This presentation looks at Poisson’s ratio of nucleus pulposus tissue, comparison of experimental results with a biphasic poroviscoelastic finite element ...
Farrell, Mark, Riches, Philip
core +3 more sources
Journal of Orthopaedic Surgery and Research, 2021 Background To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment. Methods The gene expression data was downloaded from the NCBI Gene Expression Omnibus (GEO) database ( https ...
Cun Zhang +3 more
doaj +1 more source