Results 11 to 20 of about 19,939 (253)
Scutellarin reduces apoptosis of nucleus pulposus cells in intervertebral disc degeneration of rat models [PDF]
Jichu yixue yu linchuangObjective To investigate the effects of scutellarin (SCU) on apoptosis of nucleus pulposus cells and the Janus kinas 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in intervertebral disc degeneration (IVDD) model rats.
LI Na, ZHANG Peng, ZHANG Nan, LIN Wei, LIU Defeng, ZHENG Jihui
doaj +2 more sources
Comparative Analysis of Dual-miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair. [PDF]
JOR SpineNucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Néill TN +7 more
europepmc +2 more sources
Study on the effeets of hypoxia on the level of OCN in nucleus pulposus cells
上海师范大学学报. 自然科学版, 2015 In order to studing the effects of hypoxia on the level of OCN in nucleus pulposus cells.Human nucleus pulposus cell were line cultured in vitro.The growth morphological of nucleus pulposus cells were observed under a microscope.Two groups of cells were ...
WU Yuanmin +3 more
doaj +1 more source
陆军军医大学学报, 2022 Objective To investigate the effect of human tissue kallikrein-binding protein, kallistatin (KS) on intervertebral disc nucleus pulposus cells and the possible mechanism.
LU Enhu, LI Qingshu, TAN Yun
doaj +1 more source
Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]
European Cells & Materials, 2021 The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj +1 more source
Inhibition of PLA2G15 Alleviates Palmitic Acid-Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration. [PDF]
JOR SpineLMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Duan L +7 more
europepmc +2 more sources
陆军军医大学学报, 2023 Objective To explore the effect and mechanism of zinc finger protein A20 in the nucleus pulposus cells of intervertebral disc with hypoxic conditions.
GUO Shuaichi +4 more
doaj +1 more source
针刺研究, 2023 ObjectiveTo observe the effect of electroacupuncture （EA） at “Jiaji”（EX-B2） on body mass， motor function， expression of caveolin-1 （Cav-1） in nucleus pulposus cells and annulus fibrosus tissue， telomerase activi-ty， relative telomere length and different
ZHANG Yan-lin +4 more
doaj
Pharmacological Research - Modern Chinese Medicine, 2022 Yiqi Huoxue Decoction (abbreviated as YH in this paper) is a well-accepted traditional Chinese medicine formula used for the treatment of lumbar disc herniation (LDH).
Feng Mao +9 more
doaj +1 more source
PLoS ONE, 2013 Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis of intervertebral disc degeneration. Recent findings revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many pathological ...
Xin Yu +6 more
doaj +1 more source