Results 41 to 50 of about 15,808 (150)

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study

JOR Spine, 2018
Mechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of
Steven V. Beekmans, Kaj S. Emanuel, Theodoor H. Smit, Davide Iannuzzi   +3 more
doaj   +1 more source

Clinical practices in the management of cervical Hansen type I intervertebral disc herniation among veterinary neurologists in North America and Europe

Journal of Small Animal Practice, EarlyView.
Objectives To describe current clinical practices in the management of cervical Hansen type I intervertebral disc herniation among American College of Veterinary Internal Medicine/European College of Veterinary Neurology neurologists. Materials and Methods An anonymous web‐based survey was distributed via professional listservs between October and ...
A. Mondino, M. Riobó, N. J. Olby, S. Moore, P. J. Early   +4 more
wiley   +1 more source

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, EarlyView.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Journal of Biological Engineering
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source

Clinical Efficacy and Learning Curve of Far‐Lateral Approach (FLA) in Uni‐Portal Non‐Coaxial Spinal Endoscopic Surgery (UNSES) in the Treatment of Lumbar Degenerative Diseases: A Prospective Study

Orthopaedic Surgery, EarlyView.
UNSES via FLA is a safe and effective minimally invasive technique for treating complex lumbar degenerative diseases. It has a certain learning curve, and the inflection point is about the 16th case. After mastering the key techniques such as anatomical positioning, endoscopic manipulation and hemostasis, the surgeon can gradually reach the proficiency
Mengchen Yin, Wenlong Yu, Yan Lou, Jianfeng Sha, Yang Xue, Dong Zhang, Kaipeng Huang, Kai Lv, Zhichao Ge, Jianmin Li, Jiajun Wu, Hao Sun, Shuqiang Wang   +12 more
wiley   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degeneration

Journal of Translational Medicine
Background Intervertebral disc degeneration (IDD) is a primary cause of low back pain and, in severe cases, can lead to disability. Current treatments for low back pain remain limited in efficacy, underscoring the need for a deeper understanding of the ...
Yili Xu, Zuozhi Xie, Shubo Gu, Xiang Zhao, Di Zhao, Zhengzheng Wu, Jinfeng Wang, Tao Xu, Ruxue Xu, Zhenhua Feng, Yong Qiu, Zezhang Zhu, Yang Yu, Bo Shi, Jun Jiang   +14 more
doaj   +1 more source