Results 61 to 70 of about 348,318 (186)

BMSCs-derived exosomes overexpressing TGM2 inhibit lactate-induced oxidative stress related apoptosis in nucleus pulposus cells

陆军军医大学学报
Objective To explore the role and mechanism of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) overexpressing transglutaminase 2 (TGM2) in lactate-mediated oxidative stress-induced apoptosis in nucleus pulposus cells.
LOU Jinhui, GAO Xiaoxin, ZHANG Yuyao
doaj   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

The expression of FOXC2 in human nucleus pulposus tissue.

, 2016
(A) The expression of FOXC2 exhibited significantly higher levels in 4 degenerative nucleus pulposus tissue compared to 4 idiopathic scoliosis nucleus pulposus tissue.
Yi Liu (36759), Zheng Wang (25883), Yong Chen (109188), Changfeng Fu (622226), Feng Xu (89016), Zhigang Qu (2174023), Zhenyu Wang (580934)   +6 more
core   +1 more source

Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study

JOR Spine, 2018
Mechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of
Steven V. Beekmans, Kaj S. Emanuel, Theodoor H. Smit, Davide Iannuzzi   +3 more
doaj   +1 more source

Retrieval Practice Through an Integrated Anatomy Laboratory Experience in a Doctor of Physical Therapy Curriculum

Clinical Anatomy, EarlyView.
ABSTRACT Gross anatomy is a foundational first‐year component of Doctor of Physical Therapy (DPT) curriculum, with limited future vertical integration. Retrieval practice and spaced learning to enhance retention are rarely embedded in second‐year DPT coursework.
Christina M. Cuka, Kellie C. Huxel Bliven, Emilio J. Puentedura   +2 more
wiley   +1 more source

Effect of electroacupuncture on expression of autophagy-related proteins in nucleus pulposus of cervical spondylosis rabbits

针刺研究
ObjectiveTo observe the effects of electroacupuncture （EA） on the morphological changes of intervertebral disc tissues， apoptosis of nucleus pulposus cells， and the protein expression of Unc-51 like autophagy-activated kinase 1 （ULK1）， homologous series ...
CHEN Jia-li, ZHAO Zi-ying, GAO Hang, XU Yin-qing, WANG Guang-yi   +4 more
doaj   +2 more sources

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Journal of Biological Engineering
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source