Results 61 to 70 of about 19,939 (253)

Supplementary Material for: Lentivirus-shRNA mediated prolyl hydroxylase 2 knockdown increases HIF-1α and inhibits nucleus pulposus cells degeneration

, 2021
Hypoxia-inducible factor (HIF) plays a crucial role in regulating the hypoxia-inducible state of nucleus pulposus cells in the intervertebral disc. In addition, the oxygen-dependent conversion of HIF-1α in nucleus pulposus cells is controlled by the ...
Shi F. (11705888), Mao G. (11705891), Yang X. (3341028), Yang C. (4140691), Zhou C. (3333507), Chen Q. (3335055), Liu L. (2945928), Song Y. (3137490)   +7 more
core   +2 more sources

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, EarlyView.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

CORE STABILITY EXERCISE PADA PASIEN HERNIA NUCLEUS PULPOSUS [PDF]

, 2019
Hernia Nucleus Pulposus adalah suatu keadaan dimana terjadi pengeluaran isi nukleus dari dalam diskus intervertebralis (ruptur diskus) sehingga nukleus dari diskus menonjol kedalam annulus (cincin fibrosa disekitar diskus) dan memberikan manifestasi ...
ANDIK ROHMANA, 151610213004
core  

Summary of the characteristics of nucleus pulposus tissues obtained from patients: cumulative population doubling level, initial telomere length, and initial telomerase activity of nucleus pulposus chondrocytes.

, 2015
Summary of the characteristics of nucleus pulposus tissues obtained from patients: cumulative population doubling level, initial telomere length, and initial telomerase activity of nucleus pulposus chondrocytes.
Ki-Won Kim (833560), Seo-Won Jeong (833557), Joon-Pyo Juhn (833559), Sung-Wook Cho (833558), Jun-Seok Lee (181420)   +4 more
core   +1 more source

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Journal of Biological Engineering
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source

Biomechanical Effects of Two Types of 3D‐Printed Prosthesis Reconstruction After Single‐Segmental Total En Bloc Spondylectomy: A Finite Element Analysis

Orthopaedic Surgery, EarlyView.
The choice of prosthesis in spinal reconstruction plays an essential role in patients' postoperative outcomes. This study aims to investigate the biomechanical effects of two types of 3D‐printed prosthesis and titanium mesh cage (TMC) after total en bloc spondylectomy.
Jiasheng Chen, Ben Wang, Yang Luo, Xiang Li, Yanchao Tang, Zihe Li, Hua Zhou, Panpan Hu, Xiaoguang Liu, Zhongjun Liu, Feng Wei   +10 more
wiley   +1 more source

Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degeneration

Journal of Translational Medicine
Background Intervertebral disc degeneration (IDD) is a primary cause of low back pain and, in severe cases, can lead to disability. Current treatments for low back pain remain limited in efficacy, underscoring the need for a deeper understanding of the ...
Yili Xu, Zuozhi Xie, Shubo Gu, Xiang Zhao, Di Zhao, Zhengzheng Wu, Jinfeng Wang, Tao Xu, Ruxue Xu, Zhenhua Feng, Yong Qiu, Zezhang Zhu, Yang Yu, Bo Shi, Jun Jiang   +14 more
doaj   +1 more source

Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells

Open Life Sciences
Abstract Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs.
Meng, Yingying, Liu, Wei, Liu, Haifeng, Yu, Chengwei   +3 more
openaire   +3 more sources