Results 61 to 70 of about 15,808 (150)

Knockdown of miR-660 protects nucleus pulposus cells from TNF-a-induced apoptosis by targeting serum amyloid A1

Journal of Orthopaedic Surgery and Research, 2020
Background Intervertebral disc degeneration (IVDD) is a well-known cause of lower back pain, which is induced by multiple factors including increased apoptosis and decreased survival of nucleus pulposus cells.
Hao Jie Zhang, Xue Hai Ma, Song Lin Xie, Shu lian Qin, Cong Zhi Liu, Zhen Guo Zhang   +5 more
doaj   +1 more source

Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang, Kristin L. Lenz, Emma Shen, Collin Murray, Nikitha Ada, Sarada Prasad, Mohammed Kuziez, Farshid Guilak, Arin K. Oestreich   +8 more
wiley   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The intervertebral disc serves a critical role in spine function, but with aging and degeneration the disc undergoes changes that alter disc mechanics, and degeneration is often implicated in low back pain. The objective of this study was to quantify and evaluate the impact of aging and degeneration on in vivo lumbar disc mechanics ...
Harrah R. Newman, John M. Peloquin, Edward J. Vresilovic, Dawn M. Elliott   +3 more
wiley   +1 more source

Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

Effect of electroacupuncture on expression of autophagy-related proteins in nucleus pulposus of cervical spondylosis rabbits

针刺研究
ObjectiveTo observe the effects of electroacupuncture （EA） on the morphological changes of intervertebral disc tissues， apoptosis of nucleus pulposus cells， and the protein expression of Unc-51 like autophagy-activated kinase 1 （ULK1）， homologous series ...
CHEN Jia-li, ZHAO Zi-ying, GAO Hang, XU Yin-qing, WANG Guang-yi   +4 more
doaj  

Nucleus Pulposus Resorption Following a Paraspinal Hook‐Needle Intervention for Lumbar Disc Herniation: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT The paraspinal hook‐needle intervention is a minimally invasive needle‐based procedure performed under local anesthesia using a specialized hook‐shaped needle at clinically selected lumbar segments. We report the case of a 70‐year‐old woman who presented with intermittent low back pain for more than 10 years, recently aggravated and ...
Mengying Xiao, Zhengchao Cai, Hairui Zhu, Shuanglin Mou, Wensheng Zhu   +4 more
wiley   +1 more source

Decellularized Nucleus Pulposus Matrix/Chitosan Hybrid Hydrogels for Nucleus Pulposus Tissue Engineering

Global Spine Journal
Study Design Basic research Objective To prepared 3 DNPM/chitosan hybrid hydrogels and chose the best DNPM/chitosan hybrid hydrogel for NP tissue engineering.
Yu Zhang MM, Yifeng Li MM, Chen Liu MD, Xifu Shang PhD   +3 more
doaj   +1 more source

Electrospun Scaffold Containing TGF-β1 Promotes Human Mesenchymal Stem Cell Differentiation toward a Nucleus Pulposus-Like Phenotype under Hypoxia

Global Spine Journal, 2014
Introduction Intervertebral disc degeneration is considered to have a close relation with nucleus pulposus calcification. Electrospunning provides promising strategies for fabricating nanofibrous scaffolds that resemble the extracellular matrix ...
Y. Zhou, X. Cui, J. Wang
doaj   +1 more source

Prevalence of Chronic Pain and Associated Factors Among Nursing Students in Heilongjiang Province, China: A Cross‐Sectional Study

Nursing Open, Volume 13, Issue 8, August 2026.
ABSTRACT Aim This study explored the prevalence and potential factors influencing chronic pain and provided increased theoretical and practical support for future studies on nursing students from a novel perspective. Design This study applied a cross‐sectional study design.
Siqi Liu, Yujin Xie, Zhengxi Chen, Xiwei Chen, Lei Cao, Yue Qin, Mei Yin, Yang Fu, Lei Shi   +8 more
wiley   +1 more source