Results 81 to 90 of about 348,318 (186)

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Clinical practices in the management of cervical Hansen type I intervertebral disc herniation among veterinary neurologists in North America and Europe

Journal of Small Animal Practice, EarlyView.
Objectives To describe current clinical practices in the management of cervical Hansen type I intervertebral disc herniation among American College of Veterinary Internal Medicine/European College of Veterinary Neurology neurologists. Materials and Methods An anonymous web‐based survey was distributed via professional listservs between October and ...
A. Mondino, M. Riobó, N. J. Olby, S. Moore, P. J. Early   +4 more
wiley   +1 more source

Raw data of nucleus pulposus cell viability and metabolic activity.

Raw data of nucleus pulposus cell viability and metabolic activity.
Rebecca A. Wachs (8906522), Uyen N. Nguyen (17282883), Fei San Lee (17282886), Eliza J. Munns (18495806)   +3 more
core   +1 more source

E-MEXP-2488 - Transcription profiling of human nucleus pulposus vs articular cartilage cell types

, 2010
Human nucleus pulposus cell vs articular ...
Division of Cell Matrix Biology & Regenerative Medicine (L5), Richardson, Stephen; id_orcid   +1 more
core   +1 more source

MANAJEMEN NYERI PASIEN RAWAT JALAN PADA KASUS HERNIA NUKLEUS PULPOSUS MELALUI CORE STABILITY

Jurnal Vokasi Indonesia, 2014
Herniated nucleus pulposus (HNP) is a situation where the annulus fibrosus along nucleus pulposus protruding into the spinal canal. HNP patients often complain of back pain radiating to the lower limbs, especially when bending activity.
Elsa Roselina, Safrin Arifin, Hermito Gidion   +2 more
doaj   +1 more source

Overexpression of microRNA-185 alleviates intervertebral disc degeneration through inactivation of the Wnt/-catenin signaling pathway and downregulation of Galectin-3

Molecular Pain, 2020
Background Recent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. In the present study, we examined the role of miR-185 in nucleus pulposus cell behavior in vitro and the
Zhennan Yun, Yuhang Wang, Wei Feng, Junting Zang, Daguang Zhang, Yuhang Gao   +5 more
doaj   +1 more source

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source

VnP-16 reduces inflammatory cytokine expression in the nucleus pulposus of mice with SpA.

, 2022
IL-1β, IL-6, TNF-α, IL-17A expressing cells were enumerated in the nucleus pulposus by immunohistochemical staining (n = 6 per group). ns, non-significant, *P P P < 0.001.
Seon-Yeong Lee (403007), JeongWon Choi (4900684), Sung-Hwan Park (26633), A. Ram Lee (11785412), Mi-La Cho (46882), Hong Ki Min (9417766), Byung-Moo Min (11909720)   +6 more
core   +1 more source

CORE STABILITY EXERCISE PADA PASIEN HERNIA NUCLEUS PULPOSUS [PDF]

, 2019
Hernia Nucleus Pulposus adalah suatu keadaan dimana terjadi pengeluaran isi nukleus dari dalam diskus intervertebralis (ruptur diskus) sehingga nukleus dari diskus menonjol kedalam annulus (cincin fibrosa disekitar diskus) dan memberikan manifestasi ...
ANDIK ROHMANA, 151610213004
core   +1 more source

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +1 more source