Results 71 to 80 of about 15,808 (150)

The research of transgenic human nucleus pulposus cell transplantation in the treatment of lumbar disc degeneration

Kaohsiung Journal of Medical Sciences, 2019
The present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration.
Hua‐Cong Wang, Cang‐Hai Jin, Jie Kong, Tao Yu, Jian‐Wei Guo, You‐Gu Hu, Yong Liu   +6 more
doaj   +1 more source

Directional X‐Ray Scattering and Microtomography for Laboratory‐Based Imaging of Fibrous Materials and Biological Tissues

Small Science, Volume 6, Issue 8, August 2026.
A compact laboratory X‐ray system enables directional dark‐field imaging and tomography with sensitivity to scattering along two orthogonal directions. The approach provides volumetric mapping of sub‐resolution microstructure in engineering and biological samples, which reveals structural heterogeneity, fiber organization, and anisotropic scattering ...
Carlos Navarrete‐León, Álvaro José González‐Grajales, Harry Allan, Adam Doherty, Alissa Parmenter, Rocco D’Antuono, David Bate, Alberto Astolfo, Silvia Cipiccia, Charlotte K. Hagen, Alessandro Olivo, Marco Endrizzi   +11 more
wiley   +1 more source

Characterization of the age-dependent intervertebral disc changes in rabbit by correlation between MRI, histology and gene expression

BMC Musculoskeletal Disorders, 2011
Background The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus aging and (ii) as an appropriate ...
Gauthier Olivier, Fellah Borhane H, Lesoeur Julie, Masson Martial, Grimandi Gaël, Pot-Vaucel Marianne, Clouet Johann, Fusellier Marion, Cherel Yan, Maugars Yves, Guicheux Jérôme, Vinatier Claire   +11 more
doaj   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Scientific Reports, 2017
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular ...
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian   +7 more
doaj   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, Volume 249, Issue 2, Page 435-444, August 2026.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration

JOR Spine
Background Condoliase is an enzyme used as a treatment for lumbar disc herniation (LDH). This enzyme degrades chondroitin sulfate (CS) in the nucleus pulposus of the intervertebral disc (IVD).
Yuka Minamisawa, Taiichi Shirogane, Ippei Watanabe, Akira Dezawa   +3 more
doaj   +1 more source

Clinical Study of Ultrasound‐Guided Modified Percutaneous Endoscopic Interlaminar Discectomy Combined With Medical Chitosan in Lumbar 4–5 Disc Herniation Treatment

Orthopaedic Surgery, Volume 18, Issue 8, Page 1649-1659, August 2026.
Ultrasound‐guided PEID plus medical chitosan can effectively reduce postoperative pain and perioperative complications, demonstrating superior clinical efficacy. ABSTRACT Objective Percutaneous endoscopic lumbar discectomy (PELD) is a preferred minimally invasive surgery for lumbar disc herniation (LDH); however, postoperative recurrence, nerve root ...
Liying Cao, Jun Zhang, Mingjing Jiang, Binzhen Lin, Nan Zhong, Xiaofeng Yin, Yiyun Guan, Xiaochun Huang, Kaiming Chen   +8 more
wiley   +1 more source

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Ecotoxicology and Environmental Safety
This study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration.
Weilin Zhang, Zhencong Li, Zhongwei Wang, Kuize Liu, Shengbang Huang, Jinguo Liang, Zhiwen Dai, Weixiong Guo, Chao Mao, Siyuan Chen, Jinsong Wei   +10 more
doaj   +1 more source

Effect of acupotomy intervention on the expressions of proteoglycans in lumbar intervertebral disc of rabbits with lumbar intervertebral disc degeneration

针刺研究, 2023
Objective To observe the effect of acupotomy intervention on the expressions of biglycan(BGN), decorin(DCN) and Caspase-3 in lumbar intervertebral disc of rabbits with lumbar intervertebral disc degeneration(LIDD), so as to explore its possible mechanism
HU Jiang-shan, TANG Hong-tu, YAN Jing, LI Yi-hong, HU Xia, LI Jia, WANG Hua   +6 more
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