Results 91 to 100 of about 19,939 (253)
JOR SPINE, Volume 9, Issue 2, June 2026.The intervertebral discs (IVDs) from mice with amyloid pathologies are larger, flatter, and exhibit increased energy absorption, making these IVDs more susceptible to damage. This heightened vulnerability may predispose elderly individuals with AD to disc injuries, accelerating IVD degeneration and spinal pain. ABSTRACT Background Chronic low back pain,
C. E. Gonzalez +5 more
wiley +1 more source
Tissue engineered nucleus pulposus replacement
, 2015 A nucleus pulposus replacement is described that includes a containment balloon that can sequester synthetic and/or tissue engineered fill material(s) in the nucleus pulposus region of the IVD thus mitigating migration and expulsion of the fill materials.
Simionescu, Dan, Mercuri, Jeremy
core
A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
JOR SPINE, Volume 9, Issue 2, June 2026.A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
针刺研究ObjectiveTo observe the effects of electroacupuncture （EA） on the morphological changes of intervertebral disc tissues， apoptosis of nucleus pulposus cells， and the protein expression of Unc-51 like autophagy-activated kinase 1 （ULK1）， homologous series ...
CHEN Jia-li +4 more
doaj
JOR SPINE, Volume 9, Issue 2, June 2026.Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody +4 more
wiley +1 more source
Composite hydrogels for nucleus pulposus tissue engineering
, 2011 Tissue engineering offers a paradigm shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments, which substantially alter the biomechanical properties of the ...
Strange, DGT, Oyen, ML, ,
core
Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells
, 2014 Hyperleptinemia is implicated in obesity-associated lumbar disc degeneration. Nevertheless, the effect of leptin on the intracellular signaling of nucleus pulposus cells is not clear. The current study sought to delineate the possible involvement of the
Jun Yu +6 more
core +1 more source
Global Spine JournalStudy Design Basic research Objective To prepared 3 DNPM/chitosan hybrid hydrogels and chose the best DNPM/chitosan hybrid hydrogel for NP tissue engineering.
Yu Zhang MM +3 more
doaj +1 more source
Global Spine Journal, 2014 Introduction Intervertebral disc degeneration is considered to have a close relation with nucleus pulposus calcification. Electrospunning provides promising strategies for fabricating nanofibrous scaffolds that resemble the extracellular matrix ...
Y. Zhou, X. Cui, J. Wang
doaj +1 more source
BMC Musculoskeletal Disorders, 2011 Background The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus aging and (ii) as an appropriate ...
Gauthier Olivier +11 more
doaj +1 more source