Results 51 to 60 of about 348,318 (186)

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

The Relationship between HELQ Expression and Intervertebral Disc Degeneration

Global Spine Journal, 2016
Introduction Degeneration of the intervertebral disc, mainly of nucleus pulposus, is strongly implicated as a cause of low back pain. However, the mechanism of disc degeneration is not clear.
Shanhu Huang, Yu Zhang, Zhili Liu, Jiaming Liu   +3 more
doaj   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Summary of the characteristics of nucleus pulposus tissues obtained from patients: cumulative population doubling level, initial telomere length, and initial telomerase activity of nucleus pulposus chondrocytes.

, 2015
Summary of the characteristics of nucleus pulposus tissues obtained from patients: cumulative population doubling level, initial telomere length, and initial telomerase activity of nucleus pulposus chondrocytes.
Ki-Won Kim (833560), Seo-Won Jeong (833557), Joon-Pyo Juhn (833559), Sung-Wook Cho (833558), Jun-Seok Lee (181420)   +4 more
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Dynamic behavior of the nucleus pulposus within the intervertebral disc loading: a systematic review and meta-analysis exploring the concept of dynamic disc model

Frontiers in Bioengineering and Biotechnology
IntroductionThe dynamic disc model (DDM) is a theoretical framework in spine mechanics that theorizes the behavior of the nucleus pulposus within the intervertebral disc under various loads.
Jean-Philippe Deneuville, Jean-Philippe Deneuville, Jean-Philippe Deneuville, Maxime Billot, Alexandra Cervantes, Sylvain Peterlongo, Martin Meyer, Mezika Kolder, Marie Escande, Mathilde Bourgeois, Adrien Pallot, Adrien Pallot, Romain David, Romain David, Romain David, Manuel Roulaud, Amine Ounajim, Mark Laslett, Mathieu Sarracanie, Najat Salameh, Arnaud Germaneau, Philippe Rigoard, Philippe Rigoard, Philippe Rigoard   +23 more
doaj   +1 more source

PENETRATION OF CEFOTAXIME INTO INTERVERTEBRAL DISCS REMOVED FROM PATIENTS UNDERGOING DISCECTOMY [PDF]

Basrah Journal of Surgery, 2019
The intervertebral disc is an avascular tissue, and penetration of antibiotics occurs by passive diffusion. Cefotaxime penetration has not been well studied.
Thamer Hamdan, Mohammed hashim, Nazar Haddad, Abdullah Jawad   +3 more
doaj   +1 more source

Biomechanical Effects of Different Sitting Postures and Physiologic Movements on the Lumbar Spine: A Finite Element Study

Bioengineering, 2023
This study used the finite element method(FEM) to investigate how pressure on the lumbar spine changes during dynamic movements in different postures: standing, erect sitting on a chair, slumped sitting on a chair, and sitting on the floor.
Mingoo Cho, Jun-Sang Han, Sungwook Kang, Chang-Hwan Ahn, Dong-Hee Kim, Chul-Hyun Kim, Kyoung-Tae Kim, Ae-Ryoung Kim, Jong-Moon Hwang   +8 more
doaj   +1 more source

Atypical nucleus pulposus migration and calcification: A specific radiographic sign for lumbar rheumatoid spondylitis.

PLoS ONE
ObjectiveThis study aimed to characterize a specific radiographic manifestation of lumbar rheumatoid spondylitis.Methods and materialsThe patients diagnosed with lumbar rheumatoid spondylitis who underwent posterior lumbar fusion surgery between 1/6/2019
Haocheng Cui, Jingming Wang, Lei Wang, Xiaoduo Xu, Weimin Huang   +4 more
doaj   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source