Results 141 to 150 of about 482,535 (309)

Development and Validation of a Machine Learning‐Based Online Prognostic Model for Cervical Spondylosis Patients After Anterior Cervical Discectomy and Fusion: A Multicenter Study

JOR SPINE, Volume 8, Issue 3, September 2025.
This was a multi‐center, retrospective, and prospective study based on multiple machine learning algorithms. This online predictive tool offers a robust framework for personalized postoperative management in CS patients, potentially improving clinical outcomes.
Sitan Feng, Shengsheng Huang, Zhongxian Zhou, Bin Zhang, Chengqian Huang, Tianyou Chen, Chenxing Zhou, Shaofeng Wu, Jichong Zhu, Jiarui Chen, Jiang Xue, Xinli Zhan, Chong Liu   +12 more
wiley   +1 more source

Sensitivity analysis of permeability parameters of bovine nucleus pulposus obtained through inverse fitting of the nonlinear biphasic equation : effect of sampling strategy [PDF]

, 2012
Permeability controls the fluid flow into and out of soft tissue, and plays an important role in maintaining the health status of such tissue. Accurate determination of the parameters that define permeability is important for the interpretation of models
Biot MA, Guo L-X, Lai WM, Lide DR, Malandrino A, Mansour JM, Philip E. Riches   +6 more
core   +1 more source

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration

Cell Proliferation, 2019
Intervertebral disc degeneration (IDD) is a common cause of low back pain, which inflicts more global disability than any other condition. Although IDD was deemed to be a natural process that comes with ageing, a growing body of evidence suggested that ...
Zheng Li, Xin Chen, Derong Xu, Shugang Li, M. Chan, W. Wu   +5 more
semanticscholar   +1 more source

Short‐Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One‐Strike Trigger

JOR SPINE, Volume 8, Issue 3, September 2025.
In a bovine intervertebral disc organ culture study including biological and mechanical evaluation parameters, unloading ‐compared to loading‐ partially mitigated the degenerative cascade (Timepoint 2) previously induced with a one‐strike trigger (Timepoint 1).
Astrid Soubrier, Hermann Kasper, Nadja Vonlanthen, Ilse Jonkers, Sibylle Grad   +4 more
wiley   +1 more source

Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro

Spine Surgery and Related Research, 2019
Introduction: Intervertebral disc degeneration is strongly associated with low back pain. Cell transplantation has been extensively studied as a treatment option for intervertebral disc degeneration. It is often necessary to perform cell culture prior to
Tadashi Nukaga, Daisuke Sakai, Jordy Schol, Kaori Suyama, Tomoko Nakai, Akihiko Hiyama, Masahiko Watanabe   +6 more
doaj   +1 more source

Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective

JOR SPINE, Volume 8, Issue 3, September 2025.
This review of surgically induced IVD puncture injury animal models presents an evolution over decades to include many variations simulating distinct clinical phenotypes of IVDD, and recommends reporting a common set of injury features to facilitate cross‐study comparison.
Charu Jain, Jonathan J. Huang, Yunsoo Lee, Saad Chaudhary, Andrew C. Hecht, Alon Lai, Koichi Masuda, James Kang, James C. Iatridis   +8 more
wiley   +1 more source

Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy

Experimental and Molecular Medicine, 2019
The main pathological mechanism of intervertebral disc degeneration (IVDD) is the programmed apoptosis of nucleus pulposus (NP) cells. Oxidative stress is a significant cause of IVDD.
Wen-Ning Xu, Huo-Liang Zheng, Run-Ze Yang, Tao Liu, Wei Yu, Xinfeng Zheng, Bo Li, Shengdan Jiang, Lei-Sheng Jiang   +8 more
semanticscholar   +1 more source

Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells

Aging, 2019
The NF-κB pathway has been reported to play a very important role in the process of intervertebral disc degeneration (IVDD). Our results demonstrated that knockdown of NF-κB with P65-siRNA can significantly decrease cell apoptosis and the expression of ...
Weiwei Yi, Yafeng Wen, Fuqiang Tan, Xi Liu, Haiyang Lan, He Ye, Bo Liu   +6 more
semanticscholar   +1 more source

Relationship Between Quantitative MRI and Radiological, Histological, and Biochemical Measures of Intervertebral Disc Health in Client‐Owned, Nonchondrodystrophic‐Breed Dogs

JOR SPINE, Volume 8, Issue 3, September 2025.
The purpose of this study was to assess the sensitivity of quantitative MRI techniques in detecting disc degeneration in client‐owned, nonchondrodystrophic‐breed dogs. Thoracolumbar vertebral columns from the donated bodies of 15 dogs without a history of IVDD were imaged ex vivo at 3T MRI, and quantitative MRI values of the discs were compared to ...
Alaina L. Falck, Erick O. Buko, Kayla L. Chase, Diana Pendleton, Katie McDermott, Olivia Kim, Suhail P. Parvaze, Alexandra R. Armstrong, Susan A. Arnold, Elizabeth W. Bradley, Arin M. Ellingson, Christopher P. Ober, Aaron Rendahl, Casey P. Johnson   +13 more
wiley   +1 more source

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose, Stone Sima, Neha Chopra, Ashish Diwan, Zi Gu   +4 more
wiley   +1 more source