Results 121 to 130 of about 348,318 (186)

Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine [PDF]

Hypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown.
Tsingas, Maria, Ain, Rahatul, Risbud, Makarand V, Barve, Ruteja A, Johnston, Shira N   +4 more
core   +1 more source

Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration

JOR Spine
Background Condoliase is an enzyme used as a treatment for lumbar disc herniation (LDH). This enzyme degrades chondroitin sulfate (CS) in the nucleus pulposus of the intervertebral disc (IVD).
Yuka Minamisawa, Taiichi Shirogane, Ippei Watanabe, Akira Dezawa   +3 more
doaj   +1 more source

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Ecotoxicology and Environmental Safety
This study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration.
Weilin Zhang, Zhencong Li, Zhongwei Wang, Kuize Liu, Shengbang Huang, Jinguo Liang, Zhiwen Dai, Weixiong Guo, Chao Mao, Siyuan Chen, Jinsong Wei   +10 more
doaj   +1 more source

Herniation of Nucleus Pulposus (Labeled)

Herniation of nucleus ...
Royal College of Surgeons of Ireland (RCSI)
core  

Penatalaksanaan Fisioterapi Pada Kondisi Hernia Nucleus Pulposus L4-L5 Di RST Prof. Dr. Soedjono Magelang [PDF]

, 2015
Background: Herniated Nucleus Pulposus (HNP) is the state when the nucleus pulposus protruding out then pressed toward the spinal canal through annulus fibrosus in the intervertebral disc.
Putra Surya, Areza, , Sugiono S.Fis, MH.Kes   +1 more
core  

Genetically controlled degeneration of the nucleus pulposus in the mouse.

, 1961
A description is given of a mutation in the mouse which reduces the size of the nucleus pulposus in the intervertebral disc of the adults. The discs of these mice show greatly accelerated age changes.
Berry, R J, R. J. Berry
core   +1 more source

Composite hydrogels for nucleus pulposus tissue engineering

, 2011
Tissue engineering offers a paradigm shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments, which substantially alter the biomechanical properties of the ...
Strange, DGT, Oyen, ML, ,
core  

Soft biomaterials as a substitute for the Nucleus Pulposus [PDF]

, 2015
One of the largest health problems faced worldwide, when evaluated by direct (clinical) as well indirect cost (absenteeism), is the degeneration of the intervertebral disc (IVD) that leads to back pain and, potentially disability and individual´s quality
Nabais, João António Pires Miranda
core  

Macrophage appearance in the epineurium and endoneurium of dorsal root ganglion exposed to nucleus pulposus

, 2004
Recently, it was observed that local application of nucleus pulposus may induce a characteristic reaction at the surface of the dorsal root ganglion (DRG).
Murata, Y., Rydevik, Björn,, Takahashi, K., Olmarker, Kjell,, Takahashi, I.   +4 more
core  

PHLPP1 Regulates Inflammatory Signaling in Degenerated Nucleus Pulposus Cells in Mice and Humans. [PDF]

Cells
Chatterjee B, Khan NM, Singh T, Romesh N, Her SH, Zhang C, Drissi H, Illien-Jünger S.   +7 more
europepmc   +1 more source