Results 11 to 20 of about 494,442 (303)
Bone Research, 2022 Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major social and economic burdens; however, its underlying molecular mechanisms remain poorly defined.
Sheng Chen +11 more
semanticscholar +1 more source
NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
Cell Proliferation, 2021 Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral ...
Guangzhi Zhang +7 more
semanticscholar +1 more source
MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. [PDF]
PLoS ONE, 2013 Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis of intervertebral disc degeneration. Recent findings revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many pathological ...
Xin Yu +6 more
doaj +1 more source
Inducing Angiogenesis in the Nucleus Pulposus
Cells, 2023 Bone morphogenetic protein (BMP) gene delivery to Lewis rat lumbar intervertebral discs (IVDs) drives bone formation anterior and external to the IVD, suggesting the IVD is inhospitable to osteogenesis. This study was designed to determine if IVD destruction with a proteoglycanase, and/or generating an IVD blood supply by gene delivery of an angiogenic
Sheela R. Damle +11 more
openaire +3 more sources
Autophagy, 2021 Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD ...
Ruijun He +11 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD). However, the cellular and molecular mechanisms involved remain elusive.
Zhencong Li +11 more
semanticscholar +1 more source
Damping properties of the nucleus pulposus [PDF]
Clinical Biomechanics, 2012 The nucleus pulposus is extremely deformable and it is not uncommon to observe strain amplitudes as large as 12.5% in physiological loading conditions. It has been shown that the nucleus pulposus contributes to the damping properties of the intervertebral disc.
Arne Vogel, Dominique P. Pioletti
openaire +4 more sources
Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair
International Journal of Molecular Sciences, 2022 A growing body of evidence in humans and animal models indicates an association between intervertebral disc degeneration (IDD) and increased fibrotic elements in the nucleus pulposus (NP).
Yi Sun +4 more
semanticscholar +1 more source
Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation
Frontiers in Pharmacology, 2022 Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation ...
Xiaochun Li +17 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, 2022 The process of intervertebral disc degeneration (IVDD) is complex, and its mechanism is considered multifactorial. Apoptosis of oxidative stressed nucleus pulposus cells (NPCs) should be a fundamental element in the pathogenesis of IVDD.
Peng-Bo Chen +6 more
semanticscholar +1 more source