Results 11 to 20 of about 18,806 (262)

Inducing Angiogenesis in the Nucleus Pulposus

Cells, 2023
Bone morphogenetic protein (BMP) gene delivery to Lewis rat lumbar intervertebral discs (IVDs) drives bone formation anterior and external to the IVD, suggesting the IVD is inhospitable to osteogenesis. This study was designed to determine if IVD destruction with a proteoglycanase, and/or generating an IVD blood supply by gene delivery of an angiogenic
Sheela R. Damle, Agata K. Krzyzanowska, Maximilian K. Korsun, Kyle W. Morse, Susannah Gilbert, Han Jo Kim, Oheneba Boachie-Adjei, Bernard A. Rawlins, Marjolein C. H. van der Meulen, Matthew B. Greenblatt, Chisa Hidaka, Matthew E. Cunningham   +11 more
openaire   +3 more sources

Non-Coding RNA Extraction from Nucleus Pulposus of Intervertebral Discs with Subsequent Expression Profiling

Креативная хирургия и онкология, 2020
Background. With numerous extraction protocols for total RNA and RNA fractions, like microRNA (miRNA) and long non-coding RNA (lncRNA), available for various cell and tissue types, obtaining a high quantitative and qualitative yield from some special ...
I. F. Gareev, O. A. Beylerli, G. Yang, D. Zhang   +3 more
doaj   +1 more source

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

Journal of Orthopaedic Translation, 2023
Background: It has been demonstrated that vitamin D deficiency is associated with an increased risk of patients developing lumbar disc herniation. However, intervertebral disc degeneration caused by active vitamin D deficiency has not been reported. Thus,
Peng Wang, Cuicui Yang, Jinhong Lu, Yongxin Ren, David Goltzman, Dengshun Miao   +5 more
doaj   +1 more source

Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]

European Cells & Materials, 2021
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj   +1 more source

Advancing Intervertebral Disc Biology via Omics: Implications for Nucleus Pulposus Progenitor Cell-Based Regeneration. [PDF]

JOR Spine
Intervertebral disc degeneration (IDD) is a multifactorial condition underpinned by complex molecular mechanisms. This review highlights advances in RNA sequencing and multi‐omics approaches that have elucidated gene regulatory networks, cellular heterogeneity, and progenitor cell dynamics in the nucleus pulposus.
Stirnimann A, Schlagenhof L, Gantenbein B, Ille F.   +3 more
europepmc   +2 more sources

Kallistatin inhibits apoptosis and extracellular matrix degradation of human nucleus pulposus cells by inducing SIRT1 expression

陆军军医大学学报, 2022
Objective To investigate the effect of human tissue kallikrein-binding protein, kallistatin (KS) on intervertebral disc nucleus pulposus cells and the possible mechanism.
LU Enhu, LI Qingshu, TAN Yun
doaj   +1 more source

The Prognostic Significance of LINC00638 in Lumbar Disc Herniation and Its Effect on Senescence of Nucleus Pulposus Cells. [PDF]

JOR Spine
LINC00638 is down‐regulated in LDH patients serum, serving as a promising biomarker for LDH diagnosis and prognosis. Meanwhile, its overexpression can inhibit TNF‐α‐induced senescence of hNPCs, and LINC00638 regulates hNPCs senescence and LDH progression by modulating miR‐185‐5p. ABSTRACT Background Lumbar disc herniation (LDH) is a common degenerative
Wang Z, Liu J, Sun Y, Xu H, He W, Xu S, He X.   +6 more
europepmc   +2 more sources

Anti-Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
In this study, a bifunctional anti‐swelling hydrogel system is developed, which encapsulated anti‐senescence drugs quercetin, dasatinib, nucleus pulposus‐derived exosomes (NP‐Exo) to clear senescent nucleus pulposus cells, regulate the inflammatory disc microenvironment, and enhance nucleus pulposus cells activity, ultimately promoting the repair of ...
Chen S, Han H, Zhang Y, Li L, Wang Z, Zhang J, Han L, Kou H, Shang G, Shang C, Leng Z, Mao K, Li C, Jin L, Liu H.   +14 more
europepmc   +2 more sources

Hypoxia-induced expression of zinc finger protein A20 inhibits apoptosis and attenuates inflammation in nucleus pulposus cells

陆军军医大学学报, 2023
Objective To explore the effect and mechanism of zinc finger protein A20 in the nucleus pulposus cells of intervertebral disc with hypoxic conditions.
GUO Shuaichi, LIU Hao, HAN Zhenghan, LIU Wenjun, LIU Bo   +4 more
doaj   +1 more source

Traditional Chinese medicine promotes the resorption of herniated intervertebral discs by regulating autophagy and apoptosis

Pharmacological Research - Modern Chinese Medicine, 2022
Yiqi Huoxue Decoction (abbreviated as YH in this paper) is a well-accepted traditional Chinese medicine formula used for the treatment of lumbar disc herniation (LDH).
Feng Mao, Xiaoying Ma, Jingyun Chen, Hongwei Li, Zhijia Ma, Feng Dai, Baixue Xu, Jingtao Liu, Hong Jiang, Pengfei Yu   +9 more
doaj   +1 more source