Results 11 to 20 of about 473,018 (289)
Molecular MedicineBackground Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the normal biological properties of disc ...
Tao Ma +4 more
doaj +2 more sources
Penetration of Glycopeptide Antibiotics in Nucleus Pulposus
Spine, 1993 The penetration of the glycopeptide antibiotics vancomycin and teicoplanin into the nucleus pulposus of rabbits was studied. Blood samples were obtained at 0.5, 1, 4, 8, and 24 hours after intravenous administration of 30 mg/kg vancomycin or 16 mg/kg teicoplanin.
Gaetano J. Scuderi +4 more
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Journal of Orthopaedic Surgery and Research, 2020 Background Intervertebral disc degeneration (IVDD) is a well-known cause of lower back pain, which is induced by multiple factors including increased apoptosis and decreased survival of nucleus pulposus cells.
Hao Jie Zhang +5 more
doaj +2 more sources
Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype [PDF]
Journal of Functional BiomaterialsThe intervertebral disc, an anatomical compartment interposed between vertebral bodies, plays a key role in spine flexibility and compression loading.
Narjes Rashidi +4 more
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Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment. [PDF]
JOR SpineCondoliase digested chondroitin sulfate locally, and did not digest the collagen fibers that form the supportive architecture of the nucleus pulposus. ABSTRACT Background Condoliase is a treatment for lumbar disc herniation. This enzyme exerts its medicinal effects by digesting chondroitin sulfate (CS), which is abundant in the nucleus pulposus ...
Watanabe I, Takeda K, Shirogane T.
europepmc +2 more sources
Molecular Therapy: Nucleic Acids, 2021 Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted.
Yiqiang Sun +3 more
doaj +1 more source
Advancing Intervertebral Disc Biology via Omics: Implications for Nucleus Pulposus Progenitor Cell-Based Regeneration. [PDF]
JOR SpineIntervertebral disc degeneration (IDD) is a multifactorial condition underpinned by complex molecular mechanisms. This review highlights advances in RNA sequencing and multi‐omics approaches that have elucidated gene regulatory networks, cellular heterogeneity, and progenitor cell dynamics in the nucleus pulposus.
Stirnimann A +3 more
europepmc +2 more sources
Immune exposure: how macrophages interact with the nucleus pulposus
Frontiers in Immunology, 2023 Intervertebral disc degeneration (IDD) is a primary contributor to low back pain. Immune cells play an extremely important role in modulating the progression of IDD by interacting with disc nucleus pulposus (NP) cells and extracellular matrix (ECM ...
Peng Feng +5 more
semanticscholar +1 more source
Journal of Nanobiotechnology, 2023 Background Intervertebral disc degeneration (IVDD) is a major contributor to spinal disorders. Previous studies have indicated that the infiltration of immunocytes, specifically macrophages, plays a crucial role in the advancement of IVDD. Exosomes (exo)
Xin Zhao +6 more
semanticscholar +1 more source
Advancement of science, 2023 Exogenous stem cell therapy and endogenous repair has shown great potential in intervertebral disc regeneration. However, limited nutrients and accumulation of lactate largely impair the survival and regenerative capacity of implanted stem cells and ...
Yizhong Peng +14 more
semanticscholar +1 more source