Results 11 to 20 of about 482,535 (309)

The Mucopolysaccharides of Nucleus Pulposus. [PDF]

Acta Chemica Scandinavica, 1955
S. Gardell, Lennart Rodén, A. Vestermark, Albertina Caglieris   +3 more
openalex   +4 more sources

On the Biology of Nucleus Pulposus [PDF]

Acta Orthopaedica Scandinavica, 1951
Bengt Sylvén
openalex   +4 more sources

Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells [PDF]

Open Life Sciences
Abstract Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs.
Meng Yingying, Liu Wei, Liu Haifeng, Yu Chengwei   +3 more
doaj   +4 more sources

Protein in the Nucleus Pulposus of the Intervertebral Disk [PDF]

Nature, 1962
THE nucleus pulposus of the normal human intervertebral disk consists of collagen fibrils dispersed in a gel of polysaccharide and protein complexes. During ageing collagen fibrils are deposited as a matrix showing increasing orientation with age as seen from X-ray diffraction investigations1.
P. R. Blakey, F. Happey, A. Naylor, Robert L. Turner   +3 more
openalex   +4 more sources

The Proteinpolysaccharides of Bovine Nucleus Pulposus

Journal of Biological Chemistry, 1967
Abstract Bovine nucleus pulposus has been found to be a good source of a series of proteinpolysaccharides containing chondroitin 6-sulfate and keratan sulfate. Six distinct fractions have been separated, totaling 40% of the dry weight of the tissue. Each fraction contains protein, chondroitin 6-sulfate, and keratan sulfate, but the proportions of these
Lawrence Rosenberg, Maxwell Schubert, John Sandson   +2 more
openalex   +3 more sources

Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration

Advancement of science, 2023
Exogenous stem cell therapy and endogenous repair has shown great potential in intervertebral disc regeneration. However, limited nutrients and accumulation of lactate largely impair the survival and regenerative capacity of implanted stem cells and ...
Yizhong Peng, Xuanzuo Chen, Qimin Zhang, Sheng Liu, Wei Wu, Kanglu Li, Hui Lin, Xiangcheng Qing, Yan Xiao, Baichuan Wang, Daping Quan, Shiqing Feng, Zilong Rao, Ying Bai, Zengwu Shao   +14 more
semanticscholar   +1 more source

Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration

Cell Cycle, 2023
Intervertebral disc degeneration (IVDD), a widely known contributor to low back pain (LBP), has been proved to be a global health challenging conundrum. Hesperidin (hesperetin-7-O-rutinoside, HRD) is a flavanone glycoside that belongs to the subgroup of ...
Jian Zhu, Ruping Sun, Chen Yan, Kaiqiang Sun, Lu Gao, B. Zheng, Jian-gang Shi   +6 more
semanticscholar   +1 more source

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Experimental and Molecular Medicine, 2022
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of
Weifeng Zhang, Gaocai Li, Rongjin Luo, J. Lei, Yu Song, Bingjin Wang, Liang Ma, Zhiwei Liao, Wencan Ke, Hui Liu, Wenbin Hua, K. Zhao, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Kun Wang, Cao Yang   +16 more
semanticscholar   +1 more source

Inducing Angiogenesis in the Nucleus Pulposus

Cells, 2023
Bone morphogenetic protein (BMP) gene delivery to Lewis rat lumbar intervertebral discs (IVDs) drives bone formation anterior and external to the IVD, suggesting the IVD is inhospitable to osteogenesis. This study was designed to determine if IVD destruction with a proteoglycanase, and/or generating an IVD blood supply by gene delivery of an angiogenic
Sheela R. Damle, Agata K. Krzyzanowska, Maximilian K. Korsun, Kyle W. Morse, Susannah Gilbert, Han Jo Kim, Oheneba Boachie-Adjei, Bernard A. Rawlins, Marjolein C. H. van der Meulen, Matthew B. Greenblatt, Chisa Hidaka, Matthew E. Cunningham   +11 more
openaire   +3 more sources

MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. [PDF]

PLoS ONE, 2013
Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis of intervertebral disc degeneration. Recent findings revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many pathological ...
Xin Yu, Zheng Li, Jianxiong Shen, William K K Wu, Jinqian Liang, Xisheng Weng, Guixing Qiu   +6 more
doaj   +1 more source