Results 41 to 50 of about 482,535 (309)
A bovine nucleus pulposus explant culture model [PDF]
Journal of Orthopaedic Research, 2021 AbstractLow back pain is a global health problem that is frequently caused by intervertebral disc degeneration (IVDD). Sulfated glycosaminoglycans (sGAGs) give the healthy nucleus pulposus (NP) a high fixed charge density (FCD), which creates an osmotic pressure that enables the disc to withstand high compressive forces.
Salzer, Elias +3 more
openaire +6 more sources
MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K. [PDF]
PLoS ONE, 2013 The precise role of apoptosis in the pathogenesis of intervertebral disc degeneration (IDD) remains to be elucidated. We analyzed degenerative nucleus pulposus (NP) cells and found that the expression of miR-27a was increased.
Gang Liu +5 more
doaj +1 more source
The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?
European Cells & Materials, 2021 The intervertebral disc (IVD) is a complex tissue, and its degeneration remains a problem for patients, without significant improvement in treatment strategies.
J. Guerrero +5 more
semanticscholar +1 more source
Global Spine Journal, 2022 Study Design Basic research Objective To prepared 3 DNPM/chitosan hybrid hydrogels and chose the best DNPM/chitosan hybrid hydrogel for NP tissue engineering. Methods Three DNPM/chitosan hybrid hydrogels were fabricated by changing the ratio of the decellularized NP matrix to chitosan and crosslinking with genipin.
Yu Zhang +3 more
openaire +2 more sources
Molecular Therapy: Nucleic Acids, 2021 Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted.
Yiqiang Sun +3 more
doaj
LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2/ARE axis
European Journal of Medical Research, 2021 Background This study aimed to assess the role and mechanism of lncRNA NEAT1 in intervertebral disc degeneration (IVD). Methods LncRNA profile (GSE56081) between IVD and healthy control was downloaded from the Gene Expression Omnibus (GEO) database and ...
Cheng Li +6 more
doaj +1 more source
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To investigate the effect of hydrogel stiffness on nucleus pulposus cell phenotype and its function in repairing intervertebral disc degeneration in rats.Methods·Methacrylate gelatin (GelMA) hydrogels with different concentrations were ...
CHEN Zehao +4 more
doaj +1 more source
Clinical reasoning in canine spinal disease: what combination of clinical information is useful? [PDF]
, 2015 Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from the
ABRAMSON +36 more
core +2 more sources
Journal of the Belgian Society of Radiology, 2022 Magnetic resonance images (MRI) of migrated nucleus pulposus after collagenase treatment of lumbar disc herniation are rarely published. Here, we describe a 65-year-old woman with L5-S1 intervertebral disc herniation on the rear left.
Bai Jin Tao Sun +3 more
doaj +1 more source
Comparison of clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with acute non compressive nucleus pulposus extrusion [PDF]
, 2016 OBJECTIVE To compare clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with presumptive acute noncompressive nucleus pulposus extrusion (ANNPE). DESIGN Retrospective study. ANIMALS 51 dogs with ischemic myelopathy and
De Decker, S +3 more
core +2 more sources