Results 41 to 50 of about 494,442 (303)

MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21

open access: yesMolecular Therapy: Nucleic Acids, 2021
Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted.
Yiqiang Sun   +3 more
doaj  

MR Imaging of Migrated Nucleus Pulposus after Collagenase Injection of Lumbar Disc Herniation: A Case Report

open access: yesJournal of the Belgian Society of Radiology, 2022
Magnetic resonance images (MRI) of migrated nucleus pulposus after collagenase treatment of lumbar disc herniation are rarely published. Here, we describe a 65-year-old woman with L5-S1 intervertebral disc herniation on the rear left.
Bai Jin Tao Sun   +3 more
doaj   +1 more source

Nucleus-nucleus scattering in perturbative QCD with $N_c\to\infty$ [PDF]

open access: yesPhys.Lett. B483 (2000) 115-123, 2000
In the perturbative QCD with $N_c\to\infty$ equations for the amplitude of the nucleus-nucleus scattering are derived by the effective field method. The asymptotic form of the solution is discussed. It is argued that in the high-energy limit the total nucleus-nucleus cross-sections become constant and purely geometrical.
arxiv   +1 more source

A bovine nucleus pulposus explant culture model [PDF]

open access: yesJournal of Orthopaedic Research, 2021
AbstractLow back pain is a global health problem that is frequently caused by intervertebral disc degeneration (IVDD). Sulfated glycosaminoglycans (sGAGs) give the healthy nucleus pulposus (NP) a high fixed charge density (FCD), which creates an osmotic pressure that enables the disc to withstand high compressive forces.
Salzer, Elias   +3 more
openaire   +6 more sources

Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence

open access: yesFrontiers in Cell and Developmental Biology, 2022
Enhancer RNAs (eRNAs) are noncoding RNAs that synthesized at active enhancers. eRNAs have important regulatory characteristics and appear to be significant for maintenance of cell identity and information processing.
Yulin Huang   +9 more
doaj   +1 more source

Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress-Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy. [PDF]

open access: yesJOR Spine
In this study, we utilized LC/MS‐based untargeted metabolomics analysis to examine changes in the metabolite profiles of NP cells under stress conditions. Upon analysis, PE was identified as a differentially abundant metabolite for its decreased content within advanced‐stage NP cells.
Dong Y   +9 more
europepmc   +2 more sources

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. [PDF]

open access: yes, 2017
Nucleus pulposus (NP) cells reside in a physiologically hyperosmotic environment within the intervertebral disc. TonEBP/NFAT5 is an osmo-sensitive transcription factor that controls expression of genes critical for cell survival under hyperosmotic ...
Choi, Hyowon   +5 more
core   +2 more sources

Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF‐1α–BNIP3 Axis

open access: yesJournal of Bone and Mineral Research, 2020
Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of the intervertebral disc and are predominantly glycolytic due to robust HIF‐1 activity.
Vedavathi Madhu   +7 more
semanticscholar   +1 more source

TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling

open access: yesCellular Physiology and Biochemistry, 2015
Background/Aims: Chondroitin sulfate synthase 1 (CHSY1) is a glycosyltransferases involved in the biosynthesis of chondroitin and dermatan sulfate glycosaminoglycan (GAG).
Bo Hu   +7 more
doaj   +1 more source

Arbitrary amplitude nucleus-acoustic solitary waves in thermally degenerate plasma systems [PDF]

open access: yes, 2020
A rigorous theoretical investigation is made of arbitrary amplitude nucleus acoustic solitary waves (SWs) in a fully ionized multi-nucleus plasma system (consisting of thermally degenerate electron species and non-degenerate warm light as well as heavy nucleus species).
arxiv   +1 more source

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