Results 41 to 50 of about 473,018 (289)

Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy

Stem Cells, 2021
Degeneration of the cartilage endplate (CEP) induces intervertebral disc degeneration (IVDD). Nucleus pulposus cell (NPC) apoptosis is also an important exacerbating factor in IVDD, but the cascade mechanism in IVDD is not clear.
Liwen Luo, Xiuying Jian, Hui Sun, Jinghao Qin, Yanqiu Wang, Ji Zhang, Zi-gang Shen, Di Yang, Chang‐qing Li, P. Zhao, Minghan Liu, Z. Tian, Yue Zhou   +12 more
semanticscholar   +1 more source

Hypoxia-induced expression of zinc finger protein A20 inhibits apoptosis and attenuates inflammation in nucleus pulposus cells

陆军军医大学学报, 2023
Objective To explore the effect and mechanism of zinc finger protein A20 in the nucleus pulposus cells of intervertebral disc with hypoxic conditions.
GUO Shuaichi, LIU Hao, HAN Zhenghan, LIU Wenjun, LIU Bo   +4 more
doaj   +1 more source

Traditional Chinese medicine promotes the resorption of herniated intervertebral discs by regulating autophagy and apoptosis

Pharmacological Research - Modern Chinese Medicine, 2022
Yiqi Huoxue Decoction (abbreviated as YH in this paper) is a well-accepted traditional Chinese medicine formula used for the treatment of lumbar disc herniation (LDH).
Feng Mao, Xiaoying Ma, Jingyun Chen, Hongwei Li, Zhijia Ma, Feng Dai, Baixue Xu, Jingtao Liu, Hong Jiang, Pengfei Yu   +9 more
doaj   +1 more source

The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?

European Cells & Materials, 2021
The intervertebral disc (IVD) is a complex tissue, and its degeneration remains a problem for patients, without significant improvement in treatment strategies.
J. Guerrero, S. Häckel, A. Croft, S. Hoppe, C. Albers, B. Gantenbein   +5 more
semanticscholar   +1 more source

MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K. [PDF]

PLoS ONE, 2013
The precise role of apoptosis in the pathogenesis of intervertebral disc degeneration (IDD) remains to be elucidated. We analyzed degenerative nucleus pulposus (NP) cells and found that the expression of miR-27a was increased.
Gang Liu, Peng Cao, Huajiang Chen, Wen Yuan, Jianxi Wang, Xianye Tang   +5 more
doaj   +1 more source

Decellularized Nucleus Pulposus Matrix/Chitosan Hybrid Hydrogels for Nucleus Pulposus Tissue Engineering

Global Spine Journal, 2022
Study Design Basic research Objective To prepared 3 DNPM/chitosan hybrid hydrogels and chose the best DNPM/chitosan hybrid hydrogel for NP tissue engineering. Methods Three DNPM/chitosan hybrid hydrogels were fabricated by changing the ratio of the decellularized NP matrix to chitosan and crosslinking with genipin.
Yu Zhang, Yifeng Li, Chen Liu, Xifu Shang   +3 more
openaire   +2 more sources

Effect of hydrogel stiffness on nucleus pulposus cell phenotypes in vitro and its repairment of intervertebral disc in vivo

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effect of hydrogel stiffness on nucleus pulposus cell phenotype and its function in repairing intervertebral disc degeneration in rats.Methods·Methacrylate gelatin (GelMA) hydrogels with different concentrations were ...
CHEN Zehao, LÜ Zhendong, ZHANG Zhen, CUI Wenguo, ZHANG Yuhui   +4 more
doaj   +1 more source

LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2/ARE axis

European Journal of Medical Research, 2021
Background This study aimed to assess the role and mechanism of lncRNA NEAT1 in intervertebral disc degeneration (IVD). Methods LncRNA profile (GSE56081) between IVD and healthy control was downloaded from the Gene Expression Omnibus (GEO) database and ...
Cheng Li, Xinjian Ma, Chenfei Ni, Jingyan Xu, Yinfei Xie, Junwei Kan, Xiaoli Wei   +6 more
doaj   +1 more source

Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence

Frontiers in Cell and Developmental Biology, 2022
Enhancer RNAs (eRNAs) are noncoding RNAs that synthesized at active enhancers. eRNAs have important regulatory characteristics and appear to be significant for maintenance of cell identity and information processing.
Yulin Huang, Jiaming Yang, Xizhe Liu, Xiaoshuai Wang, Kai Zhu, Zemin Ling, Baozhu Zeng, Ningning Chen, Shaoyu Liu, Fuxin Wei   +9 more
doaj   +1 more source

Scutellarin reduces apoptosis of nucleus pulposus cells in intervertebral disc degeneration of rat models [PDF]

Jichu yixue yu linchuang
Objective To investigate the effects of scutellarin (SCU) on apoptosis of nucleus pulposus cells and the Janus kinas 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in intervertebral disc degeneration (IVDD) model rats.
LI Na, ZHANG Peng, ZHANG Nan, LIN Wei, LIU Defeng, ZHENG Jihui
doaj   +1 more source