Results 101 to 110 of about 12,671,316 (204)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Beyond Magnitude: How Math Expertise Guides Number Representation [PDF]

, 2015
Previous studies on numeric cognition have focused primarily on magnitude, based on its role as a core feature of number knowledge. In this paper, we report the results of three experiments investigating adults’ sensitivity to properties of number ...
Brower, Autumn, Rogers, Timothy T, Murphy, April D, Hubbard, Edward Moscoso del Prado   +3 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Multimodal semantic quantity representations: further evidence from Korean Sign Language

Frontiers in Psychology, 2012
Korean deaf signers performed a number comparison task on pairs of Arabic digits. In their RT profiles, the expected magnitude effect was systematically modified by properties of number signs in Korean Sign Language in a culture-specific way (not ...
Frank eDomahs, Frank eDomahs, Elise eKlein, Elise eKlein, Korbinian eMoeller, Korbinian eMoeller, Hans-Christoph eNuerk, Hans-Christoph eNuerk, Byung-Chen eYoon, Klaus eWillmes   +9 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Reinforcer magnitude and demand under fixed-ratio schedules with domestic hens [PDF]

, 2014
This study compared three methods of normalizing demand functions to allow comparison of demand for different commodities and examined how varying reinforcer magnitudes affected these analyses.
Grant, Amber A., Surrey Jackson, Temple, W, Foster, T.M, Jackson, S, Poling, A, Alan Poling, Temple, William, T. Mary Foster, Grant, A, William Temple, Poling, Alan, Jennifer Kinloch, Kinloch, J.M, Foster, T. Mary, Kinloch, Jennifer, Jackson, Surrey, Amber A. Grant   +17 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Numerical synesthesia is more than just a symbol-induced phenomenon

Frontiers in Psychology, 2013
Limor eGertner, Isabel eArend, Avishai eHenik   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The ‘odd–even effect’: the link between the number of parties and district magnitude

In electoral systems with districts that vary in magnitude, the number of seats to be filled in each district will be even or odd. We argue that such a variation has crucial political consequences, called the ‘odd–even effect’. In low-magnitude districts,
I Coma, Ferran Martinez, Lago Peñas, Ignacio, Lago, Ignacio, Martínez i Coma, Ferran   +3 more
core   +1 more source