Results 81 to 90 of about 2,209 (285)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Sturmian numeration systems and decompositions to palindromes

, 2018
International audienceWe extend classical Ostrowski numeration systems, closely related to Sturmian words, by allowing a wider range of coefficients, so that possible representations of a number n better reflect the structure of the associated ...
Frid, Anna, E., Frid, Anna,, Anna E. Frid   +2 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Two-base numeration systems

, 2013
Вводяться двобазисні системи числення, що узагальнюють стандартні системи числення, основані на розкладанні чисел за степенями заданого базисного числа. Наведено результати, а також приклад застосування для кодування чисел і дерев.
Анисимов, А.В.
core  

Linear numeration systems of order two

, 1988
A numeration system is a sequence of integers such that any integer can be represented by means of the sequence using integers of bounded size. We study numeration systems defined by linear recurrences of order two.
Frougny, Christiane
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Numeration and Enumeration

, 2012
In this paper, numeration systems defined by recurrent sequences are considered. We present a class of recurrences yielding numeration systems for which the words corresponding to greedy expressions for natural numbers are easily described.
DANIELE A. GEWURZ, Gewurz, Daniele A., MEROLA, FRANCESCA   +2 more
core   +1 more source

Multi-dimensional sets recognizable in all abstract numeration systems [PDF]

, 2011
peer reviewedWe prove that the subsets of N^d that are S-recognizable for all abstract numeration systems S are exactly the 1-recognizable sets.
Narad Rampersad, Émilie Charlier, Anne Lacroix, Charlier, Emilie, Rampersad, Narad, Lacroix, Anne   +5 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source