Results 91 to 100 of about 1,153,963 (287)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Optimum dynamic analysis of 2D frames using free-scaled wavelet functions

Latin American Journal of Solids and Structures
This paper presents a wavelet-based scheme for dynamic analysis of 2-dimensional (2D) frames. In the proposed approach, free-scaled wavelet functions are developed for Multi-Degrees-of-Freedom (MDOF) structures, particularly, complex Chebyshev and simple
S.H. Mahdavi, H.A. Razak
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Influence of a Given Field of Temperature on the Blood Pressure Variation: Variational Analysis, Numerical Algorithms and Simulations

Axioms
This article presents a fluid–elastic structure interaction (FSI) problem when the temperature variation of the two media is also taken into account. We introduced the mathematical description of this interaction in a recent article.
Ruxandra Stavre, Alexandra Ciorogar
doaj   +1 more source

Numerical approximation of fluid-structure interaction problems [PDF]

Applied and Computational Mechanics, 2008
This paper is devoted to numerical approximations of fluid-structure interaction problems. Namely the problem of interaction of turbulent flow over flexibly supported airfoil is addressed. In order to model the turbulence effects the flow is described by
Sváček P.
doaj  

The Numerical Applications of (ABM) and (AMM) Numerical Methods on Some Neutrosophic and Dual Problems [PDF]

Neutrosophic Sets and Systems
The objective of this paper is to present two neutrosophic numerical methods for finding the numerical solutions for some neutrosophic differential equations, where a numerical comparison between AMM and ABM methods with numerical tables that clarify ...
Ahmed Salem Heilat
doaj   +1 more source

Efficient numerical approximation of a non-regular Fokker-Planck equation associated with first-passage time distributions. [PDF]

BIT Numer Math, 2022
Boehm U, Cox S, Gantner G, Stevenson R.
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Numerical Approximation of the Nonequilibrium Model of Gradient Elution Chromatography Considering Linear and Nonlinear Solvent Strength Models. [PDF]

ACS Omega, 2022
Rehman N, Qamar S.
europepmc   +1 more source