Results 41 to 50 of about 221,693 (258)

INVESTIGATION OF TOTAL STRESSES IN RECTANGULAR SECTION CONDUIT BODY LOCATED ON A CLAY BASE

Мелиорация и гидротехника, 2023
Purpose: to study the total stresses in the rectangular section conduit body TOTAL S-YY and S-XX while analyzing the influence of the soil height above the conduit and the load from the vehicle axle on the conduit. At the same time, the influence factors
Degtyarev Vladimir G., Degtyareva Olga G., Sekisov Alexander N.   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Integrated approach to gas-dynamic designing of supersonic air intakes of aircraft

Aviation, 2021
The analytical and experimental studies of the aircraft’s supersonic air intakes have been carried out. An integrated approach to the gas-dynamic designing of aircraft’s supersonic air intakes that eliminates the scale effect problem of a wind tunnel ...
Aleksey Kornev, Sergii Stetsenko, Victor Yatsenko, Anatoliy Smolyakov, Dmytro Kalinichenko   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Discrete mathematical model of the scattering process of E-polarized wave on a periodic impedance grating

Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika, 2019
The method of numerical modeling of wave scattering by periodic impedance grating is considered. In the case of a harmonic dependence of the field on time and the uniformity of the structure along a certain axis, the three-dimensional problem reduces to ...
Vladimir D. Dushkin, Stanislav Zhuchenko, Oleksii V. Kostenko   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Reduced-Dimension Method for Crank–Nicolson Mixed Finite Element Solution Coefficient Vectors of the Extended Fisher–Kolmogorov Equation

Axioms
A reduced-dimension (RD) method based on the proper orthogonal decomposition (POD) technology and the linearized Crank–Nicolson mixed finite element (CNMFE) scheme for solving the 2D nonlinear extended Fisher–Kolmogorov (EFK) equation is proposed.
Xiaohui Chang, Hong Li
doaj   +1 more source