Results 91 to 100 of about 144,309 (270)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Benchmarking of implicit numerical integration methods for stiff unified constitutive equations in metal forming applications

Cogent Engineering
Unified constitutive equations have been developed to model the behaviour of metallic materials under various processing conditions. These constitutive equations usually take the form of a set of ordinary differential equations (ODEs), which must be ...
James Dear, Ruiqiang Zhang, Zhusheng Shi, Jianguo Lin   +3 more
doaj   +1 more source

Data-Augmented Numerical Integration in State Prediction: Rule Selection and Error Compensation

, 2023
Jindřich Duník, Ladislav Král, Jakub Matoušek, Marek Brandner, Ondřej Straka   +4 more
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The curse of dimensionality for numerical integration of smooth functions II [PDF]

, 2013
Aicke Hinrichs, Erich Novak, Mario Ullrich, Henryk Woźniakowski   +3 more
openalex   +1 more source

A new high-order compact finite difference scheme based on precise integration method for the numerical simulation of parabolic equations [PDF]

, 2020
Changkai Chen, Xiaohua Zhang, Zhang Liu, Yage Zhang   +3 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Analytical Equivalent Circuit Extraction of Foreign Metal Objects in WPT Systems

IEEE Access
Wireless power transfer (WPT) technologies are rapidly attracting attention because of their wide application field. Among them, inductive power transfer (IPT) technology is most promising for daily usage in households.
Ryo Shirai, Goro Nakao, Masanori Hashimoto   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Dynamical Model of Rotation and Orbital Coupling for Deimos

Remote Sensing
This paper introduces a novel dynamical model, building upon the existing dynamical model for Deimos in the current numerical ephemerides, which only encompasses the simple libration effects of Deimos.
Kai Huang, Lijun Zhang, Yongzhang Yang, Mao Ye, Yuqiang Li   +4 more
doaj   +1 more source