Results 61 to 70 of about 2,110,114 (235)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multilevel Quasi-Interpolation on Chebyshev Sparse Grids

Computation
This paper investigates the potential of utilising multilevel quasi-interpolation techniques on Chebyshev sparse grids for complex numerical computations.
Faisal Alsharif
doaj   +1 more source

Interpolation structures and verb movement in Triestino. [PDF]

, 2022
openIl presente elaborato si occupa di testare ed analizzare le strutture di interpolazione nella varietà dialettale di Trieste in cui il nesso inseparabile tra clitico e verbo viene spezzato da elementi avverbiali. In particolare si vuole verificare se
BOSCOLO, SARA
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Optimal control for a fractional tuberculosis infection model including the impact of diabetes and resistant strains

Journal of Advanced Research, 2019
The objective of this paper is to study the optimal control problem for the fractional tuberculosis (TB) infection model including the impact of diabetes and resistant strains. The governed model consists of 14 fractional-order (FO) equations.
N.H. Sweilam, S.M. AL-Mekhlafi, D. Baleanu   +2 more
doaj   +1 more source

Gradient Estimation using Lagrange Interpolation Polynomials [PDF]

In this paper we use Lagrange interpolation polynomials to obtain good gradient estimations.This is e.g. important for nonlinear programming solvers.As an error criterion we take the mean squared error.This error can be split up into a deterministic and ...
Brekelmans, R.C.M., Hamers, H.J.M., Hertog, D. den, Driessen, L.   +3 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Quasi-interpolation projectors for subdivision function spaces

Graphical Models
Subdivision surfaces as an extension of splines have become a promising technique for addressing PDEs on models with complex topologies in isogeometric analysis.
Hailun Xu, Zepeng Wen, Hongmei Kang
doaj   +1 more source

Estimates of the Aggregate Quarterly Capital Stock for the Post- War U.S. Economy [PDF]

We construct quarterly aggregate gross and net capital stock series for the post-war U.S. economy using annual capital stock, capital depreciation, and capital discard figures along with quarterly investment series. We construct nominal and real measures
Daniel Levy, Haiwei Chen
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source