Results 71 to 80 of about 2,110,114 (235)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Models of Random Processes and Their Particular Application in the Optimum Linear Interpolation and Forecasting

Известия высших учебных заведений России: Радиоэлектроника, 2016
Models of correlation functions of random processes are considered. Numerical methods show that efficiency of the optimum linear interpolation and forecasting is defined by higher derivative of random processes.
V. A. Golovkov
doaj  

Bivariate High-Accuracy Hermite-Type Multiquadric Quasi-Interpolation Operators

Journal of Mathematics
In this paper, a kind of Hermite-type multiquadric quasi-interpolation operator is constructed by combining an extended univariate multiquadric quasi-interpolation operator with a bivariate Hermite interpolation polynomial.
Ruifeng Wu
doaj   +1 more source

LOCAL INTERPOLATION AND APPROXIMATION IN TASKS OF HEURISTIC SYNTHESIS OF DIGITAL FILTER

Российский технологический журнал, 2018
The article has an overview character with elements of generalization, but at the same time it includes information brought to the level of immediate practical implementation.
V. N. Isakov, P. I. Timoshenko
doaj   +1 more source

Error concealment using motion field interpolation [PDF]

, 1998
In the context of block-based video coding, two error concealment algorithms are presented. The first algorithm is based on bilinear motion field interpolation (BMFI). For each pel in a damaged block, the algorithm recovers a motion vector using bilinear
Al-Mualla, MES, Canagarajah, CN, Al-Mualla, M, Bull, DR   +3 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Homogeneous numerical cubature formulas of interpolatory type

Journal of Numerical Analysis and Approximation Theory, 2002
In this paper we construct homogeneous numerical cubature formulas based on some numerical multivariate interpolation schemes.
Gheorghe Coman, Maria Solomon
doaj   +2 more sources

A novel parameterized multiquadric quasi-interpolation operator with its optimal parameters

Results in Applied Mathematics
The shape parameter c plays a crucial role in determining the accuracy and effectiveness of multiquadric quasi-interpolation algorithm. However, a few works discuss the shape parameter c in multiquadric quasi-interpolation operator.
Hualin Xiao, Dan Qu
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source