Results 111 to 120 of about 73,046 (353)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
First kind integral equations for the numerical solution of the plane Dirichlet problem [PDF]
, 1985 summary:We present, in a uniform manner, several integral equations of the first kind for the solution of the two-dimensional interior Dirichlet boundary value problem. We apply a general numerical collocation method to the various equations, and thereby
M. S. Abou El‐Seoud +1 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
On asymptotic behaviour at infinity and the finite section for integral equations on the half-line
, 1994 We consider integral equations on the half-line of the form and the finite section approximation to x obtained by replacing the infinite limit of integration by the finite limit β.
Chandler-Wilde, SN
core
Trial methods for Bernoulli's free boundary problem [PDF]
, 2014 Free boundary problems deal with solving partial differential equations in a domain, a part of whose boundary is unknown – the so-called free boundary. Beside the standard boundary conditions that are needed in order to solve the partial differential ...
Mitrou, Giannoula
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Journal of Taibah University for Science, 2017 Numerical schemes have been developed for solutions of systems of nonlinear mixed VolterraâFredholm integral equations of the second kind based on the First Boubaker polynomials (FBPs). The classical operational matrices are derived.
Sara Davaeifar, Jalil Rashidinia
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020 Background. Parabolic differential equations of mathematical physics play very important role in mathematical modeling of the wide range of phenomena in physical and technical sciences.
I. V. Boykov, V. A. Ryazantsev
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Localized boundary-domain integral equation formulation for mixed type problems
, 2010 Copyright @ 2010 Walter de Gruyter GmbHSome modified direct localized boundary-domain integral equations (LBDIEs) systems associated with the mixed boundary value problem (BVP) for a scalar “Laplace” PDE with variable coefficient are formulated and ...
Mikhailov, SE +5 more
core +1 more source