Results 121 to 130 of about 27,823 (314)
The use of spline and singular functions in an integral equation method for conformal mapping [PDF]
, 1980 We consider the integral equation method of Symm for the conformal mapping of simply-connected domains. For the numerical solution, we examine the use of spline functions of various degrees for the approximation of the source density o. In particular, we
Papamicheal, N, Hough, DM
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Trial methods for Bernoulli's free boundary problem [PDF]
, 2014 Free boundary problems deal with solving partial differential equations in a domain, a part of whose boundary is unknown – the so-called free boundary. Beside the standard boundary conditions that are needed in order to solve the partial differential ...
Mitrou, Giannoula
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Survey on the Numerical Methods for ODE's Using the Sequence of Successive Approximations [PDF]
, 2005 Here we present the error estimations in the numerical methods for Cauchy problems corresponding to ODE’s, which use the sequence of successive approximations and quadrature rules such as trapezoidal rule and perturbed trapezoidal ...
Bica, Alexandru Mihai
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Metric Based Upscaling for Partial Differential Equations with a Continuum of Scales [PDF]
, 2007 Numerical upscaling of problems with multiple scale structures have attracted increasing attention in recent years. In particular, problems with non-separable scales pose a great challenge to mathematical analysis and simulation.
Zhang, Lei
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Analysis of some localized boundary-domain integral equations [PDF]
, 2009 Some direct segregated localized boundary-domain integral equation (LBDIE) systems associated with the Dirichlet and Neumann boundary value problems (BVP) for a scalar "Laplace" PDE with variable coefficient are formulated and analysed. The parametrix is
Mikhailov, SE +2 more
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Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020 Background. Parabolic differential equations of mathematical physics play very important role in mathematical modeling of the wide range of phenomena in physical and technical sciences.
I. V. Boykov, V. A. Ryazantsev
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source