Results 121 to 130 of about 7,929,866 (305)
Influence of analysis and design models on minimum weight design [PDF]
The results of numerical experiments designed to illustrate how the minimum weight design, accuracy, and cost can be influenced by: (1) refinement of the finite element analysis model and associated load path problems, and (2) refinement of the design ...
Ramanathan, R. K. +3 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
FireFire resistance is a critical aspect of passive fire protection, particularly in door systems that must maintain integrity under extreme conditions. This paper presents the thermal and structural performance of a single-leaf sandwich fire door, with the ...
Margarida Fernandes +5 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Numerical Optimization of Plasmonic Biosensors [PDF]
, 2011 Since the engineering control of the deposition of nanometric gold plates on substrates the Surface Plasmon Resonance (SPR) based sensor has become one of the most successful label-free and commercially developed optical sensor, with applications to biology (Hoaa et al., 2007; Kolomenskii et al., 1997; Kretschman & Raether, 1968; Lecaruyer et al., 2006)
openaire +4 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
SensorsThe Whale Optimization Algorithm (WOA) is a bio-inspired metaheuristic algorithm known for its simple structure and ease of implementation. However, WOA suffers from issues such as premature convergence, low population diversity in the later stages of ...
Junhao Wei +6 more
doaj +1 more source