Results 41 to 50 of about 16,000,085 (252)
EPJ Web of Conferences, 2016 The numerical solution of nonlinear degenerate reaction-diffusion problems often meets two kinds of difculties: singularities in space – finite speed of propagation of compact supports’ initial perturbations and possible sharp moving fronts, where the ...
Dimova Stefka, Mihaylova Yonita
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A minimal mathematical model of nonphotochemical quenching of chlorophyll fluorescence [PDF]
, 2011 Copyright © 2010 Elsevier Ireland Ltd.
Lokstein, Heiko +15 more
core +1 more source
Quenching for Discretizations of a Nonlocal Parabolic Problem with Neumann Boundary Condition
Cubo, 2010 In this paper, under some conditions, we show that the solution of a discrete form of a nonlocal parabolic problem quenches in a finite time and estimate its numerical quenching time.
Théodore K Boni, Diabaté Nabongo
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Multi-Size-Mesh, Multi-Time-Step Algorithm for Noise Computation on Curvilinear Meshes [PDF]
, 2013 Aeroacoustic problems are often multi-scale and a zonal refinement technique is thus desirable to reduce computational effort while preserving low dissipation and low dispersion errors from the numerical scheme.
CORRE, Christophe +3 more
core +1 more source
Journal of Numerical Analysis and Approximation Theory, 2011 This paper concerns the study of the numerical approximation for the following boundary value problem \begin{equation*} \begin{cases} u_t(x,t)-u_{xx}(x,t)= -a(x)f(u(x,t)), & 00, \\ u(x,0)= u_{0}(x)>0, & 0\leq x \leq 1, \\ \end{cases} \end{equation*
Halima Nachid
doaj +2 more sources
Critical cooling rate on carbide precipitation during quenching of austenitic manganese steel [PDF]
China Foundry, 2010 Critical cooling rate to avoid carbide precipitation during quenching of austenitic manganese steel was investigated by means of optical microscopy, image analyzer and numerical analysis. An efficient heat treatment analysis program including temperature-
Youn-Soo Ham +2 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
An Efficient Fluid-Dynamic Analysis to Improve Industrial Quenching Systems
Metals, 2017 This paper addresses the problem of understanding the relationship between fluid flow and heat transfer in industrial quenching systems. It also presents an efficient analysis to design or optimize long standing quenching tanks to increase productivity ...
Manuel de J. Barrena-Rodríguez +4 more
doaj +1 more source