Results 41 to 50 of about 16,688,726 (247)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Quenching for Discretizations of a Nonlocal Parabolic Problem with Neumann Boundary Condition
Cubo, 2010 In this paper, under some conditions, we show that the solution of a discrete form of a nonlocal parabolic problem quenches in a finite time and estimate its numerical quenching time.
Théodore K Boni, Diabaté Nabongo
doaj
EPJ Web of Conferences, 2016 The numerical solution of nonlinear degenerate reaction-diffusion problems often meets two kinds of difculties: singularities in space – finite speed of propagation of compact supports’ initial perturbations and possible sharp moving fronts, where the ...
Dimova Stefka, Mihaylova Yonita
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Critical cooling rate on carbide precipitation during quenching of austenitic manganese steel [PDF]
China Foundry, 2010 Critical cooling rate to avoid carbide precipitation during quenching of austenitic manganese steel was investigated by means of optical microscopy, image analyzer and numerical analysis. An efficient heat treatment analysis program including temperature-
Youn-Soo Ham +2 more
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
An Efficient Fluid-Dynamic Analysis to Improve Industrial Quenching Systems
Metals, 2017 This paper addresses the problem of understanding the relationship between fluid flow and heat transfer in industrial quenching systems. It also presents an efficient analysis to design or optimize long standing quenching tanks to increase productivity ...
Manuel de J. Barrena-Rodríguez +4 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source