Results 51 to 60 of about 12,580 (256)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quenching for semidiscretizations of a semilinear heat equation with potential and general nonlinearity

Journal of Numerical Analysis and Approximation Theory, 2011
This paper concerns the study of the numerical approximation for the following boundary value problem  \begin{equation*} \begin{cases} u_t(x,t)-u_{xx}(x,t)= -a(x)f(u(x,t)), & 00, \\ u(x,0)= u_{0}(x)>0, & 0\leq x \leq 1, \\ \end{cases} \end{equation*
Halima Nachid
doaj   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A co-condensation model for in-flight synthesis of metal-carbide nanoparticles in thermal plasma jet [PDF]

, 2008
We present a theoretical analysis of the formation, growth, and transport of two-component nanoparticles in thermal plasma jet. The approach of the aerosol science and the idea of multicomponent co-condensation are employed for the analysis.
Mohanty, P., Vorobev, A., Zikanov, O.
core   +1 more source

Numerical investigation of local heat-release rates and thermo-chemical states in side-wall quenching of laminar methane and dimethyl ether flames [PDF]

, 2020
The local heat-release rate and the thermo-chemical state of laminar methane and dimethyl ether flames in a side-wall quenching configuration are analyzed.
Popp, S., Zirwes, T., Steinhausen, M., Strassacker, C., Maas, U., Dreizler, A., Hasse, C., Sadiki, A., Kosaka, H., Zentgraf, F., Luo, Y.   +10 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A splitting moving mesh method for reaction-diffusion equations of quenching type [PDF]

, 2006
This paper studies the numerical solution of multi-dimensional nonlinear degenerate reaction–diffusion differential equations with a singular force term over a rectangular domain. The equations may generate strong quenching singularities.
Lin, Ping, Tan, R.C.E., Tan, Roger C. E., Liang, K., Lin, P., Ong, M.T., Liang, Kewei, Ong, Ming Tze   +7 more
core   +1 more source

Method of lines and finite difference schemes with the exact spectrum for solution the hyperbolic heat conduction equation

Mathematical Modelling and Analysis, 2011
This paper is concerning with the 1-D initial–boundary value problem for the hyperbolic heat conduction equation. Numerical solutions are obtained using two discretizations methods – the finite difference scheme (FDS) and the difference scheme with the ...
Harijs Kalis, Andris Buikis
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Detonation Diffraction in Mixtures with Various Degrees of Instability [PDF]

, 2005
Planar laser induced fluorescence (PLIF) is widely used in combustion diagnostics but has only recently been successfully applied to detonation. The strong spatial variations in temperature, pressure, and background composition under these conditions ...
Pintgen, Florian Peter
core   +1 more source