Results 51 to 60 of about 72,811 (257)

Nonlocal probes of thermalization in holographic quenches with spectral methods [PDF]

, 2015
We describe the application of pseudo-spectral methods to problems of holographic thermal quenches of relevant couplings in strongly coupled gauge theories. We focus on quenches of a fermionic mass term in a strongly coupled N=4 supersymmetric Yang-Mills
Buchel, Alex, Myers, Robert C., van Niekerk, Anton   +2 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Doppler cooling to the recoil limit using sharp atomic transitions

, 2002
In this paper, we develop an analytical approach to Doppler cooling of atoms by one- or two-photon transitions when the natural width of the excited level is so small that the process leads to a Doppler temperature comparable to the recoil temperature. A
Allegrini, Anderson, Aspect, Bidel, Binnewies, Biraben, Cagnac, Gordon, Greytak, Huber, Hänsch, Jean Claude Garreau, Kasevich, Kasevich, Katori, Katori, Setija, Vogel, Véronique Zehnlé, Wallis, Zehnlé   +20 more
core   +1 more source

Temporal signatures of leptohadronic feedback mechanisms in compact sources [PDF]

, 2012
The hadronic model of Active Galactic Nuclei and other compact high energy astrophysical sources assumes that ultra-relativistic protons, electron-positron pairs and photons interact via various hadronic and electromagnetic processes inside a magnetized ...
A. Mastichiadis, Aharonian, Asano, Asano, Begelman, Böttcher, Böttcher, Böttcher, Böttcher, Coppi, Dimitrakoudis, Kazanas, Kazanas, Kirk, M. Petropoulou, MAGIC Collaboration, Mannheim, Mastichiadis, Mastichiadis, Mastichiadis, Mastichiadis, Moderski, Mukherjee, Mücke, Mücke, Paredes, Petropoulou, Romero, Romero, Sikora, Stawarz, Stern, Stern, Stern   +33 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Numerical Quenching for Heat Equations with Coupled Nonlinear Boundary Flux

International Journal of Analysis and Applications, 2019
In this paper, we study a numerical approximation of the following problem ut = uxx, vt = vxx, 0 < x < 1, 0 < t < T; ux(0, t) = u−m(0, t) + v−p(0, t), vx(0, t) = u−q (0, t) + v−n(0, t) and ux(1, t) = vx(1, t) = 0, 0 < t < T, where m, p,
Kouame Beranger Edja, Koffi N'guessan, Brou Jean-Claude Koua, Kidjegbo Augustin Toure   +3 more
doaj   +2 more sources

Quenching for Discretizations of a Nonlocal Parabolic Problem with Neumann Boundary Condition

Cubo, 2010
In this paper, under some conditions, we show that the solution of a discrete form of a nonlocal parabolic problem quenches in a finite time and estimate its numerical quenching time.
Théodore K Boni, Diabaté Nabongo
doaj  

Critical cooling rate on carbide precipitation during quenching of austenitic manganese steel [PDF]

China Foundry, 2010
Critical cooling rate to avoid carbide precipitation during quenching of austenitic manganese steel was investigated by means of optical microscopy, image analyzer and numerical analysis. An efficient heat treatment analysis program including temperature-
Youn-Soo Ham, Jeong-Tae Kim, Si-Young Kwak   +2 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Quenching for semidiscretizations of a semilinear heat equation with potential and general nonlinearity

Journal of Numerical Analysis and Approximation Theory, 2011
This paper concerns the study of the numerical approximation for the following boundary value problem  \begin{equation*} \begin{cases} u_t(x,t)-u_{xx}(x,t)= -a(x)f(u(x,t)), & 00, \\ u(x,0)= u_{0}(x)>0, & 0\leq x \leq 1, \\ \end{cases} \end{equation*
Halima Nachid
doaj   +2 more sources