Results 91 to 100 of about 2,580 (202)

Progress in Aptamer-Mediated Drug Delivery Vehicles for Cancer Targeting and Its Implications in Addressing Chemotherapeutic Challenges [PDF]

, 2014
Aptamers are novel oligonucleotides with flexible three-dimensional configurations that recognize and bind to their cognate targets, including tumor surface receptors, in a high-affinity and highly specific manner.
Dong, Shiwu, Ge, Liang, Huang, He, Zhang, Yuan, Zhu, Jie   +4 more
core   +1 more source

Case report on the role of aggressive palliative surgery in lung NUT carcinoma after induction chemoimmunotherapy. [PDF]

, 2023
INTRODUCTION AND IMPORTANCE: NUT (nuclear protein in testis) carcinoma of the lung is an aggressive, poorly differentiated squamous cell carcinoma that has a poor prognosis. Currently, there are no recommended guidelines with limited literature regarding
Alcasid, Nathan, Banks, Kian, Sun, Angela, Velotta, Jeffrey   +3 more
core   +1 more source

Overcoming BET‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2–FTH1 axis

The FEBS Journal, Volume 292, Issue 23, Page 6345-6364, December 2025.
Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Faniello   +9 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +2 more sources

Some Tumours Can Drive You Nuts: An Enigmatic Case of Metastatic Lymph

Apollo Medicine
Introduction: NUT carcinoma (NC) is a rare aggressive undifferentiated malignant neoplasm. It can arise from midline and non-midline structures with no predilection for age and gender. NC is due to NUT gene rearrangement (Chromosomal translocation).
Kumudavalli Muthukumarappan, Swetha Lakshmi, Annapurneswari Subramanyan, C. S. Mani   +3 more
doaj   +1 more source

Overview and different perspectives on possible treatments related to NUT carcinoma: a systematic review

Brazilian Journal of Oncology, 2019
NUT carcinoma (midline testicular carcinoma nuclear protein) is a relatively new, rare, aggressive and underdiagnosed entity. Its sites of involvement are medial structures of the head and neck and mediastinum, but other sites may be affected, and even ...
Antonia Nayra Gomes Lopes, Martinho Hermeson de Matos Furtado, Karen Giselly Paulo Silva, Lindvaldo de Oliveira Sousa, Andrezza Vasconcelos do Vale Aguiar, Giovanni Ciarlini Silveira   +5 more
doaj   +1 more source

Research Progress on Pathogenesis and Treatment of NUT Carcinoma

Chinese Journal of Lung Cancer
NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family ...
Jiaxin DU, Xinwei ZHANG
doaj   +1 more source

Locally advanced thoracic NUT carcinoma — a case report and literature review

Oncology in Clinical Practice
NUT carcinoma is an extremely rare and aggressive cancer. It is characterised by the presence of a nuclear protein gene rearrangement (NUTM1) on chromosome 15q14. Nut carcinoma can occur at any age but mainly in third decade.
Piotr A. Chilczuk, Magdalena Knetki-Wróblewska   +1 more
doaj   +1 more source

Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1‐rearranged porocarcinoma

Histopathology, Volume 87, Issue 3, Page 375-387, September 2025.
Microscopic features of a NUTM1 adnexal carcinoma magnification. This neoplasm consisted of large, poorly demarcated tumors, sometimes ulcerated infiltrated the dermis and subcutaneous tissue (HPS ×10). The lesions were organized in strands, cords and larger solid nests of poorly differentiated cells characterized by enlarged, irregular nuclei (HPS ×20)
Mélanie Legrand, Baptiste Louveau, Amélie Osio, Anne Tallet, Eduardo Calonje, Jean‐Yves Scoazec, Arnaud de la Fouchardiere, Franck Tirode, Andreas Von Deimling, Klaus Busam, Ahmed Shah, Ashley Flaman, Fanélie Jouenne, Samia Mourah, Daniel Pissaloux, Sylvie Lantuejoul, Christopher A French, Keisuke Goto, Bernard Cribier, Carina A Dehner, Ahmed K Alomari, Christopher DM Fletcher, John Hanna, Nicolas Macagno, Maxime Battistella, Thibault Kervarrec   +25 more
wiley   +1 more source

Novel BRD4–NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma [PDF]

Oncogene, 2012
Nuclear protein in testis (NUT)-midline carcinoma (NMC) is a rare, aggressive disease typically presenting with a single t(15;19) translocation that results in the generation of a bromodomain-containing protein 4 (BRD4)-NUT fusion. PER-624 is a cell line generated from an NMC patient with an unusually complex karyotype that gave no initial indication ...
K, Thompson-Wicking, R W, Francis, A, Stirnweiss, E, Ferrari, M D, Welch, E, Baker, A R, Murch, A M, Gout, K W, Carter, A K, Charles, M B, Phillips, U R, Kees, A H, Beesley   +12 more
openaire   +2 more sources