Results 101 to 110 of about 2,580 (202)

Case report: Diagnosis of NUT carcinoma of hepatic origin by next-generation sequencing

Frontiers in Oncology
NUT carcinoma is a rare subcategory of squamous cell carcinoma. The latter is primarily characterized by the fusion of the coding sequence NUTM1 on chromosome 15q14 with BRD4 or BRD3, both of which are acetyl-histone binding bromodomains.
Bach Ardalan, Jose Azqueta, Jia Luo, Christopher French   +3 more
doaj   +1 more source

Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma [PDF]

Clinical Cancer Research, 2012
Abstract Purpose: NUT midline carcinoma (NMC) is a poorly differentiated squamous cancer characterized by rearrangement of the NUT gene. Research advances have provided opportunities for targeted therapy in NMC, yet the clinical features of this rare disease have not been systematically characterized.
Bauer, Daniel, Mitchell, C. M., Strait, K. M., Lathan, Christopher, Stelow, E. B., Luer, S. C., Muhammed, S., Evans, A. G., Sholl, Lynette, Rosai, J., Giraldi, E., Oakley, R. P., Rodriguez-Galindo, Carlos, London, Wendy, Sallan, Stephen, Bradner, James E, French, Christopher   +16 more
openaire   +3 more sources

Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers

Cancer Medicine, Volume 14, Issue 8, April 2025.
ABSTRACT Background Genetic testing and sequencing technologies offer a comprehensive understanding of cancer genetics, providing rapid and cost‐effective solutions. In particular, these advanced technologies play an important role in assessing the complexities of the rare cancer types affecting several systems including the bone, endocrine, digestive,
Joviana Farhat, Lara Alzyoud, Mohammad AlWahsh, Animesh Acharjee, Basem Al‐Omari   +4 more
wiley   +1 more source

Nasal immature teratoma in an elderly patient: Clinicopathological and epigenetic analogies with central nervous system counterparts, alongside genomic divergences

Neuropathology, Volume 45, Issue 2, Page 100-108, April 2025.
Germ cell tumors (GCTs) are categorized as gonadal or extra‐gonadal, based on the origin. Extra‐gonadal GCTs predominantly manifest within the central nervous system (CNS), mediastinum, retroperitoneum, and sacrococcygeal region. These malignancies are most frequently diagnosed in the pediatric, adolescent, and young adult demographics.
Shintaro Inoue, Hirokazu Takami, Shota Tanaka, Masashi Nomura, Shunsaku Takayanagi, Yuki Saito, Shu Kikuta, Kenji Kondo, Reiko Matsuura, Masako Ikemura, Sho Yamazawa, Masao Matsutani, Ryo Nishikawa, Yuko Matsushita, Koichi Ichimura, Nobuhito Saito   +15 more
wiley   +1 more source

Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) reveals pathway differences between pigs with alternate genotypes for a major host response QTL [PDF]

, 2016
GO term enrichment performed on all 10 dpi time by time comparisons. For every time by time comparison the Enrichment Score for the significant DAVID clusters as well as a description of these clusters is presented for up-regulated and down-regulated ...
Arun Kommadath, Christopher Eisley, Christopher K. Tuggle, Eric Fritz-Waters, Graham S. Plastow, Hua Bao, Igseo Choi, Jack C. M. Dekkers, James E. Koltes, James M. Reecy, Joan K. Lunney, Leluo Guan, Martine Schroyen, Paul Stothard, Robert R. R. Rowland   +14 more
core   +5 more sources

Recurrent GRHL fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases

Histopathology, Volume 86, Issue 4, Page 571-584, March 2025.
Morphological features of RCOR1::GRHL2 adnexal tumour (case 4). Aims Sebaceous neoplasms constitute a group of adnexal tumours, including sebaceous adenoma, sebaceoma and sebaceous carcinoma. Although mismatch repair deficiency may be observed, the nature of the genetic alterations contributing to the development of most of these tumours is still ...
Mélanie Legrand, Baptiste Louveau, Nicolas Macagno, Maxence Mancini, Dmitry V Kazakov, Daniel Pissaloux, Franck Tirode, Anne Tallet, Samia Mourah, Quentin Lepiller, Arnaud de la Fouchardière, Pierre Sohier, Eric Frouin, Andreas von Deimling, Keisuke Goto, Bernard Cribier, Eduardo Calonje, Saleem Taibjee, Maxime Battistella, Thibault Kervarrec   +19 more
wiley   +1 more source

Consolidation immunotherapy following concurrent chemoradiotherapy in a patient with sinonasal NUT carcinoma: a case report

Frontiers in Oncology
BackgroundNuclear protein in testis (NUT) cancers, also known as midline cancers, tends to occur in organs near the midline, such as the nasal sinuses and mediastinum. NUT carcinoma is very rare and has a poor prognosis.Case descriptionWe report the case
Xiaotao Geng, Xiaolong Chang, Xiaoli Wang, Shunjia Li, Guiyan Han, Zhiyu Song, Furong Hao, Jianwen Li   +7 more
doaj   +1 more source

Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study [PDF]

, 2019
Background: NUT carcinoma is a rare aggressive disease caused by BRD4/3-NUT fusion, and C-MYC upregulation plays a key role in the pathogenesis. Here, we report on the clinicopathological characteristics of Korean patients with NUT carcinoma and the in ...
윤선옥, 홍순원
core   +1 more source

Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors

Protein Science, Volume 33, Issue 11, November 2024.
Abstract The acetylpyrrole scaffold is an acetylated lysine mimic that has been previously explored to develop bromodomain inhibitors. When tested on the hepatoma cell line Huh7 and the breast cancer cell line MDA‐MB‐231, a few compounds in our acetylpyrrole‐thiazole library induced peculiar morphological changes, progressively causing cell death at ...
Giulia Cazzanelli, Andrea Dalle Vedove, Nicolò Sbardellati, Luca Valer, Amedeo Caflisch, Graziano Lolli   +5 more
wiley   +1 more source

NEUROPROTECTIVE EFFECT OF PRETREATMENT WITH MENTHA LONGIFOLIA L. EXTRACT ON BRAIN ISCHEMIA IN THE RAT STROKE MODEL [PDF]

, 2015
Recent studies have suggested that Mentha longifolia L. extracts (ME) have anti-inflammatory and antioxidant activities. In this paper, we attempted to determine the effect of ME in a rat stroke model. Five groups of experimental animals were used (n=14);
Eidi, Akram., Fathi, Farhad., Oryan, Shahrbanoo., Rafieian-Kopaei, Mahmoud.   +3 more
core   +1 more source