Results 111 to 120 of about 1,976,779 (364)

Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism

PPAR Research, 2012
Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα,
Hee-Jin Jun, Thomas W. Gettys, Ji Suk Chang   +2 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Modelling Phosphorus for Grassland: Agronomically and Environmentally Sustainable Advice [PDF]

, 2006
End of project reportIn 2006, the Nitrates Directive (through S.I. 378 (Anon, 2006)) was implemented in Ireland, aimed at reducing nutrient losses from agriculture to water bodies, i.e. surface waters, groundwater and estuarine waters.
Schulte, Rogier P.
core  

Volatile metabolomics highlights tea trichome's positive contribution to aroma and quality of white tea

Current Research in Food Science
Tea trichomes, rich in secondary metabolites, are hypothesized to significantly influence white tea aroma, yet their biochemical contributions remain unclear. This study investigated the volatile profiles of tea trichome and tea body across six white tea
Dandan Qi, Min Lu, Yali Shi, Xingmin Zhang, Lin Yue, Houzhen Jia, Chunwang Dong, Huimin Liu, Changbo Yuan   +8 more
doaj   +1 more source

Loss of Nutrients in Cooking [PDF]

, 1946
C. P. Stewart
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Exploring the Use of High-Resolution Satellite Images to Estimate Corn Silage Yield Within Field

Remote Sensing
Corn (Zea mays L.) silage yield monitor data offer crucial insights into spatial and temporal yield variability. However, equipment’s sensor malfunctioning can result in data loss, and yield sensor systems are expensive to purchase and maintain.
Srinivasagan N. Subhashree, Manuel Marcaida, Shajahan Sunoj, Daniel R. Kindred, Laura J. Thompson, Quirine M. Ketterings   +5 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Urban nutrient balance for Bankok [PDF]

, 2001
To enhance agricultural sustainability, former linkages between agriculture and urban waste production should be reintroduced. Therefore, to explore the options for recycling of nutrients from mega-cities, a nutrient balance model was developed.
de Vries, Fritz Pennig, Færge, Jens, Magid, Jakob   +2 more
core