Results 131 to 140 of about 1,885,929 (310)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Towards a breakthrough in nutrient recycling : State-of-the-art and recommendations for developing policy instruments in Finland [PDF]

, 2018
The report has been complemented on 11.9.2018This report describes the state-of-the-art in phosphorus and nitrogen recycling in Finland and looks at basic data on the volumes and geographical distribution of biomasses and their nutrients.
Grönroos, Juha, Iho, Antti, Kauppila, Jussi, Koikkalainen, Kauko, Koskiaho, Jari, Laine-Ylijoki, Jutta, Lantto, Raija, Lehtonen, Eeva, Luostarinen, Sari, Marttinen, Sanna, Oasmaa, Anja, Rasa, Kimmo, Sarvi, Minna, Tampio, Elina, Turtola, Eila, Valve, Helena, Venelampi, Olli, Ylivainio, Kari, zu Castell-Rüdenhausen, Malin   +18 more
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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Maize yield in a strip-till system can be increased by increasing nitrogen accumulation, plant growth, and ear development around silking stage in Northeast China

Crop Journal
Strip-till (ST), including straw mulching in the inter-row and localized fertilization in the intra-row, is a conservation tillage system for improving soil quality and crop growth.
Ye Sha, Yi Huang, Zhanhong Hao, Mingyang Gao, Jiawei Jiang, Wenlang Hu, Jingran Zhang, Zheng Liu, Xinhua Sui, Guohua Mi   +9 more
doaj   +1 more source

Determination of Ellenberg’s indicator values along an elevational gradient in Central Black Sea Region of Turkey [PDF]

, 2013
The Central Black Sea Region has an unique vegetation because different vegetation types occurred. In the present study plant communities (from Mediterranean-type to temperate forests) in the Central Black Sea Region along an elevational gradient was ...
Kutbay, H.G., Surmen, B.
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Nutrient Trading in Lake Rotorua: Goals and Trading Caps [PDF]

For a nutrient trading system to achieve the desired environmental outcome, or goal, this outcome needs to be translated into nutrient flows and allowances.
Kelly Lock, Kit Rutherford, Suzi Kerr
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