Results 111 to 120 of about 1,218,343 (310)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Nutrient deficiencies in export tree and food crops: literature review and field observations [PDF]

, 2001
This paper reviews nutrient deficiencies in agricultural crops of PNG using the literature of agronomic trials and field observations made throughout the country.
Bourke, R.M., Hartemink, A.E.
core  

Synergistic nitrification inhibitors with best management practices can achieve higher yield and nitrogen use efficiency in semi-arid saline-alkali soils

Scientific Reports
High yield and high nitrogen use efficiency are blocked by various abiotic stress, especially in arid, salinity and irrigation deficiency agricultural production system.
Zixin Zeng, Linmei Wu, Jiahuan Liu, Zengyuan Li, Bei Li, Zhiping Duan, Weifeng Zhang   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Volatile metabolomics highlights tea trichome's positive contribution to aroma and quality of white tea

Current Research in Food Science
Tea trichomes, rich in secondary metabolites, are hypothesized to significantly influence white tea aroma, yet their biochemical contributions remain unclear. This study investigated the volatile profiles of tea trichome and tea body across six white tea
Dandan Qi, Min Lu, Yali Shi, Xingmin Zhang, Lin Yue, Houzhen Jia, Chunwang Dong, Huimin Liu, Changbo Yuan   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Use of soil nematodes as indicators of soil and plant health in continuous cropping systems: A case study in dragon fruit

Journal of Integrative Agriculture
Crops produced using the practice of continuous cropping can become seriously damaged by plant-parasitic nematodes, an important indicator of continuous cropping obstacles.
Zhechao Dou, Jing Ma, Kunguang Wang, Qiaofang Lu, Zhiguang Chi, Dongming Cui, Chang Pan, Zhuchi He, Yuanmei Zuo   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Evaluating the mineral nutrient status of fresh pasture herbage using laser-induced breakdown spectroscopy [PDF]

, 2014
Comprehensive determination of the mineral nutrient status of pasture or horticultural crops currently requires leaf or herbage samples to be harvested and taken to a laboratory for analysis, which is both labour-intensive and time-consuming.
Schaare, P., Künnemeyer, Rainer, Seelye, M.   +2 more
core  

Effects of Maize–Lablab Intercropping and Lactic Acid Bacteria Additives on Forage Yield, Fermentation Quality and Profitability

Fermentation
Intercropping systems and exogenous microorganism additives are recognized for their potential to influence silage fermentation and quality. This study aims to evaluate the impacts of maize–lablab bean intercropping and lactic acid bacteria (LAB ...
Dongsheng Li, Hongyang Ren, Linfeng Zheng, Yue Hou, Hongliang Wang   +4 more
doaj   +1 more source